Navigation Links
Portal vein thrombosis is common in extraportal vein obstruction

Among the 118 patients with portal vein thrombosis, noncirrhotic and nontumoral extrahepatic portal vein obstruction are young and present with well tolerated bleed. Cirrhosis and tumor related portal vein thrombosis patients are older and have grim prognoses. Hypercoagulable state as a cause of portal vein thrombosis is less common. The idiopathic group comprises the second largest number of patients.

A research article to be published on October 21 in the World Journal of Gastroenterology addresses the etiology and clinical outcome of portal vein thrombosis. The research team led by Dr. Pankaj Jain and Dr. Sandeep Nijhawan from Sawai Man Singh Hospital, Jaipur worked on patients with portal vein thrombosis for two years. The researchers had observed that patients with portal vein thrombosis in the two groups behaved differently in etiology, presentation and prognosis. Therefore, they collected data from their centre to verify the differences.

The researchers included cirrhosis and tumor-related AND non-cirrhotic non-tumoral extrahepatic portal venous obstruction. The large sample size allowed them to obtain significant results and draw very reliable conclusions.

Factor V Leiden mutation was present in 2% of cases and is uncommon in India. Umbilical sepsis in childhood or catheterization of umbilical veins in the neonatal period may be responsible for extrahepatic portal vein obstruction in the developing countries.

Extrahepatic portal vein obstruction (EHPVO) patients were young and commonly presented with features of hematemesis, hypersplenism, pain abdomen and abdominal distension. Ten patients had acute PVT and two had presentation as acute Budd-Chiari syndrome. Cirrhosis and tumor-related portal vein thrombosis presented with abdominal distension, abdominal pain and jaundice. On follow-up of a mean period of 7 months (range 1-24 months), 48% patients had died. The role of JAK2mutation in the early diagnosis of overt or silent myeloproliferative disease cannot be undermined but requires standardization.

Therefore, portal vein thrombosis is common in cirrhotic, tumor and non-tumoral, non-cirrhotic extraportal vein obstruction. EHPVO is a benign disease whereas cirrhotic and tumoral-related portal vein obstruction has a grim prognosis. Any patient with portal vein obstruction, in whom secondary cause is not known, should have hypercoagulable work up done to find out a treatable cause. Furthermore, as a primary prevention antenatal care has to be more meticulously planned and carried out.

Dr. Pankaj Jain (doing a fellowship in gastroenterology) and Dr. Sandeep Nijhawan (Professor of Gastroenterology) are working in the Department of Gastroenterology at Sawai Man Singh College and Hospital, Jaipur.

The experts opined that this research presents a large series of patients with portal vein thrombosis which they believed will be useful to the practitioners.


Contact: You-De Chang
World Journal of Gastroenterology

Related medicine news :

1. An Online Portal To Aid Kidney Patients
2. Stockings Effective In Reducing The Effects Of Deep Vein Thrombosis
3. Travel in Aircraft can cause Thrombosis
4. Increased Risk For Venous Thrombosis In Cancer Patients
5. Computer System To Predict Deep Vein Thrombosis
6. Risk of deep vein thrombosis less in people who were flight stockings when flying
7. Tomato Extract Found To Reduce The Risk Of Thrombosis
8. Obesity Linked To Deep Vein Thrombosis
9. Deep Vein Thrombosis Risk Increased During Long Travel
10. Infections Increase Risks Of Deep Vein Thrombosis
11. Long Hours At Computer Screen May Also Cause Deep Vein Thrombosis
Post Your Comments:
(Date:10/13/2015)... CA (PRWEB) , ... October 13, 2015 , ... ... of its newest technology platform, ENGAGE, at HIMSS’s Patient Engagement Summit . ... end. , ENGAGE delivers innovative health programs and interventions via mobile devices that ...
(Date:10/13/2015)... ... October 13, 2015 , ... ProText Kinetic Panel is a typography ... Kinetic Panel, users can create energetic text animations in any layout without the use ... Cut Pro X timeline and stylize the text. With intuitive on-screen controls, users can ...
(Date:10/13/2015)... ... , ... Symposium Chairman, Dr. Rod J. Rohrich is pleased to announce that ... March 2nd and 3rd, 2016. The annual meeting, along with the Dallas Rhinoplasty ... around the world. , Key topics at this year's event will include discussions on ...
(Date:10/13/2015)... ... October 13, 2015 , ... In an age where the cost of energy ... per square foot than in 2009. The Williamsport Regional Medical Center (WRMC) campus has ... decreased by eight percent. , According to Facilities Management Administrative Director Dieter Reichmann, ...
(Date:10/13/2015)... ... October 13, 2015 , ... Dr. Poneh Ghasri, dentist in ... September 18, 2015. The research, which was conducted at the Dental Institute at King's ... show connections between stress during pregnancy and future dental health in the child. For ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... Health Gorilla ( ) today announced the ... a secure platform for clinical data and communications poised to ... manage healthcare in the US. The launch follows the closing ... total of $4.4M raised to date, with Data Collective ... , Harris Barton , Orfin Ventures and ...
(Date:10/13/2015)... --> --> Opportunities for ... Asthma and COPD Therapies market? Which areas are going to ... report shows you potential revenues to 2025, assessing data, trends, ... tables, charts, and graphs. Discover the most lucrative areas in ... lets you assess forecasted sales at overall world market and ...
(Date:10/13/2015)... SPRINGS, N.C. , Oct. 13, 2015  Yesterday ... NVS Influenza Vaccines Holly Springs manufacturing site located in ... Since 2014, the facility has produced Flucelvax ® ... has the potential for faster start-up and is not ... 2015 CSL Limited acquired the influenza vaccines business of ...
Breaking Medicine Technology: