Navigation Links
Portal vein thrombosis is common in extraportal vein obstruction
Date:10/12/2007

Among the 118 patients with portal vein thrombosis, noncirrhotic and nontumoral extrahepatic portal vein obstruction are young and present with well tolerated bleed. Cirrhosis and tumor related portal vein thrombosis patients are older and have grim prognoses. Hypercoagulable state as a cause of portal vein thrombosis is less common. The idiopathic group comprises the second largest number of patients.

A research article to be published on October 21 in the World Journal of Gastroenterology addresses the etiology and clinical outcome of portal vein thrombosis. The research team led by Dr. Pankaj Jain and Dr. Sandeep Nijhawan from Sawai Man Singh Hospital, Jaipur worked on patients with portal vein thrombosis for two years. The researchers had observed that patients with portal vein thrombosis in the two groups behaved differently in etiology, presentation and prognosis. Therefore, they collected data from their centre to verify the differences.

The researchers included cirrhosis and tumor-related AND non-cirrhotic non-tumoral extrahepatic portal venous obstruction. The large sample size allowed them to obtain significant results and draw very reliable conclusions.

Factor V Leiden mutation was present in 2% of cases and is uncommon in India. Umbilical sepsis in childhood or catheterization of umbilical veins in the neonatal period may be responsible for extrahepatic portal vein obstruction in the developing countries.

Extrahepatic portal vein obstruction (EHPVO) patients were young and commonly presented with features of hematemesis, hypersplenism, pain abdomen and abdominal distension. Ten patients had acute PVT and two had presentation as acute Budd-Chiari syndrome. Cirrhosis and tumor-related portal vein thrombosis presented with abdominal distension, abdominal pain and jaundice. On follow-up of a mean period of 7 months (range 1-24 months), 48% patients had died. The role of JAK2mutation in the early diagnosis of overt or silent myeloproliferative disease cannot be undermined but requires standardization.

Therefore, portal vein thrombosis is common in cirrhotic, tumor and non-tumoral, non-cirrhotic extraportal vein obstruction. EHPVO is a benign disease whereas cirrhotic and tumoral-related portal vein obstruction has a grim prognosis. Any patient with portal vein obstruction, in whom secondary cause is not known, should have hypercoagulable work up done to find out a treatable cause. Furthermore, as a primary prevention antenatal care has to be more meticulously planned and carried out.

Dr. Pankaj Jain (doing a fellowship in gastroenterology) and Dr. Sandeep Nijhawan (Professor of Gastroenterology) are working in the Department of Gastroenterology at Sawai Man Singh College and Hospital, Jaipur.

The experts opined that this research presents a large series of patients with portal vein thrombosis which they believed will be useful to the practitioners.


'/>"/>

Contact: You-De Chang
y.d.chang@wjgnet.com
86-108-538-1892
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. An Online Portal To Aid Kidney Patients
2. Stockings Effective In Reducing The Effects Of Deep Vein Thrombosis
3. Travel in Aircraft can cause Thrombosis
4. Increased Risk For Venous Thrombosis In Cancer Patients
5. Computer System To Predict Deep Vein Thrombosis
6. Risk of deep vein thrombosis less in people who were flight stockings when flying
7. Tomato Extract Found To Reduce The Risk Of Thrombosis
8. Obesity Linked To Deep Vein Thrombosis
9. Deep Vein Thrombosis Risk Increased During Long Travel
10. Infections Increase Risks Of Deep Vein Thrombosis
11. Long Hours At Computer Screen May Also Cause Deep Vein Thrombosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... WA (PRWEB) , ... December 09, 2016 , ... ... financial planning assistance from offices in Pasco and Richland, is initiating a charity ... overcome serious injuries resulting from a recent automobile collision. , On October ...
(Date:12/9/2016)... (PRWEB) , ... December 09, 2016 , ... Cellairis is ... and affordable repairs on iPhone , iPad and Samsung Galaxy devices ... Pearland Walmart in order to maximize convenience and accessibility for customers. While customers ...
(Date:12/9/2016)... Kentucky - Cincinnati, Ohio (PRWEB) , ... December ... ... in the production of miniature, folded, pharmaceutical inserts and outserts. As a ... Serialization Device. This addition will enable Flottman to individually code professional inserts ...
(Date:12/9/2016)... (PRWEB) , ... December 09, 2016 , ... "I have ... "I used this old family recipe, which is meant to relieve gout and pain ... gave me a 12-hour energy boost every time. It relieved what VA doctors called ...
(Date:12/9/2016)... ... December 09, 2016 , ... The Justin Veatch Fund ... (NCADD) is recommending the film Whispering Spirits and its discussion guide for ... as an education tool in the war against teen drug abuse. NCADD is ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... , Dec. 9, 2016 MSD, a ... supply chain solutions to alternate site health care facilities, ... First Choice Medical Supply ("First Choice"), a privately held ... the skilled nursing and home health segments. We would ... This compelling transaction will deliver significant ...
(Date:12/9/2016)... 9, 2016 External Defibrillators, ... ICD, Dual-Chamber ICD, Cardiac Resynchronization Therapy Defibrillators (CRT-D), ... Defibrillators The global defibrillators market ... of 5.3% from 2016-2020 and CAGR of 5.1% ... at a CAGR of 5.2% from 2016 to ...
(Date:12/9/2016)... , Dec. 9, 2016   Hudes Laser ... December featuring the multi-wavelength Astanza Trinity laser and ... specializes in laser tattoo removal, IPL hair removal, ... ultrasound therapy. Hudes Laser Aesthetica is setting high ... and promises to deliver effective, long-lasting ...
Breaking Medicine Technology: