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Porous structures help boost integration of host tissue with implants, study finds
Date:1/30/2008

njured site in the body for grafting into the site of injury, as commonly performed now. This strategy, although often effective, creates additional wounds. The work of Mao and his team suggests that it should be possible to harnesses the bodys natural tissue regeneration capacity to recruit the right cells to the site where new bone tissue is needed. Implants that naturally attract the mesenchymal stem cells that can readily differentiate into bone, fat, cartilage and other types of cells could be the way of the future, Mao says. In comparison with donor site morbidity and pain in association with autologous tissue grafting, synthetic materials have the advantage of ready and endless supply without any sacrifice of donor tissue, he says.

The approach also overcomes a practical obstacle confronting many orthopedic surgeons.

This is a hybrid approach releasing biological cues from existing orthopedic and dental implants to recruit the bodys own stem cells. Its unrealistic, at least from what we know now, to build a cell culture room next to every operating room, Mao added. Using these types of porous implants doesnt require physicians to deliver stems cells so much as it allows the patients body to send its own cells to the right place.


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Contact: Alex Lyda
mal2133@columbia.edu
212-305-0820
Columbia University Medical Center
Source:Eurekalert

Page: 1 2

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