Navigation Links
Porous structures help boost integration of host tissue with implants, study finds
Date:1/30/2008

NEW YORK Results published today in FASEB (the journal of the Federation of American Societies for Experimental Biology) by researchers at Columbia University, including Jeremy Mao of the Columbia College of Dental Medicine, demonstrate a novel way of using porous structures as a drug-delivery vehicle that can help boost the integration of host tissue with surgically implanted titanium.

Instead of being acted upon by the body as an impenetrable foreign object, the synthetic bone replacement currently being tested in rabbits features a porous material that allows for the delivery of microencapsulated bioactive cues that speed up the growth of host tissue at the site and allow for the growth of new bone.

A critical finding is that the drug dose needed for host tissue integration by this controlled-release approach is about 1/10 of that by the traditional technique of simple adsorption of the growth factor.

The approach could bring to orthopedics and dentistry a treatment that has wrought much interest and success in the field of cardiology with the development of drug-eluting stents, which take what is ordinarily an inert tube, and infuse it with drugs to make the placement of what is essentially a man-made, foreign object more compatible with the patients body, and at the same time, actively promoting healing of injured tissue.

After just four weeks, the porous implants that Mao and his team are using showed a 96 percent increase in bone-to-implant contact and a 50 percent increase in the growth of new bone over placebos.

How were such results achieved?

Since stem cells play a vital role in the growth of new bone, Mao and his team have focused on impregnating the titanium implants with a factor that homes the bodies own regenerating cells to the potential growth site to create and build on a platform for new bone.

The new approach may in the future obviate the need to harvest bone from a non-i
'/>"/>

Contact: Alex Lyda
mal2133@columbia.edu
212-305-0820
Columbia University Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Smart insulin nanostructures pass feasibility test, UT study reports
2. Pharmos Restructures Operations in Israel
3. Health Capital Group Warns of Fallout to Hospitals From the Subprime Mortgage Crisis and Urges Hospitals to Immediately Reassess Existing Debt Structures and Capital Financing Plans
4. New treatment boosts muscle function in myasthenia gravis
5. Heavy Drinking Boosts Stroke Risk for Chinese Men
6. Longer ambulance journeys boost death risk for seriously ill patients
7. Traffic Fumes Plus Genes Boosts Kids Asthma Risk
8. Heart Attack Boosts Diabetes Risk
9. Smoking Boosts Risk for Head, Neck Cancers
10. Continued Statin Use Boosts Post-Stroke Outcomes
11. U.S. Initiative Seeks to Boost Hispanic Stroke Awareness

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/29/2009)... "The YogaForce A-Line At...t; says Dr. Andrew Weil, M.D., author and physicia... field of integrative medicine. Go to www.yogafo...ss minded on the gift list. , ...- Just in time for the holidays, the YogaForce new...
(Date:11/28/2009)... , CHICAGO, Nov. 28 Get rea...ractice in the clinical routine when Siemens i...fic Assembly and Annual Meeting of the Radiologica... to December 3 at McCormick Place (Booth #825, Eas...th syngo. via , Siemens, new imaging softw...
(Date:11/28/2009)...ts offer tips to help lift spirits, recognize sign...ealthDay News) -- For many seniors, the holiday se...st loved ones, struggle with health issues or worr...Geriatrics Society. , To help overcome the seas... offers the following advice: , Get out and soci...
(Date:11/27/2009)... Biotech firm Replikins Ltd. t... H1N1 virus genomic data. It shows that the letha... (s.d. 4.5) during the virus,s current outbreak in... this week of 2.0 (s.d. 0.1). The H1N1 infectivity... Boston (PRWEB) November 27, 2009 -- B...
(Date:11/27/2009)... , ROCHESTER, N.Y., Nov. 27 /PRNewswire-USNews...ealth care provider and fortunately every year, ne...evention. But do all vaccines boost immunity for t...tional ,booster shots, needed to keep immunity str...the Journal of the American Academy of Pediatrics,...
Breaking Medicine News(10 mins):Health News:The YogaForce A-Line Mat Provides The Perfect Solution For Fitness Needs 2Health News:The YogaForce A-Line Mat Provides The Perfect Solution For Fitness Needs 3Health News:Siemens Boosts Advanced Image Reading Efficiency and Opens New Path Into The Clinical Routine with syngo(R).via 2Health News:Siemens Boosts Advanced Image Reading Efficiency and Opens New Path Into The Clinical Routine with syngo(R).via 3Health News:Siemens Boosts Advanced Image Reading Efficiency and Opens New Path Into The Clinical Routine with syngo(R).via 4Health News:Siemens Boosts Advanced Image Reading Efficiency and Opens New Path Into The Clinical Routine with syngo(R).via 5Health News:Seniors May Need Help Overcoming Holiday Blues 2Health News:Lethality of H1N1 Virus Drops to "Non-Epidemic Resting Levels" in Current Cycle; Virus' Infectivity Remains Increased 2Health News:Lethality of H1N1 Virus Drops to "Non-Epidemic Resting Levels" in Current Cycle; Virus' Infectivity Remains Increased 3Health News:Lethality of H1N1 Virus Drops to "Non-Epidemic Resting Levels" in Current Cycle; Virus' Infectivity Remains Increased 4Health News:Lethality of H1N1 Virus Drops to "Non-Epidemic Resting Levels" in Current Cycle; Virus' Infectivity Remains Increased 5Health News:Why Some Vaccines May Require A Booster 2Health News:Why Some Vaccines May Require A Booster 3
...h the National Network to End Domestic Violence, I....Va., May 18 /PRNewswire/ -- Verizon employees... nearly $7,000 worth of items to donate to five lo...wide effort to collect personal care products, clo...
...wire/ -- ACORN CRO, an oncology-focused CRO, has...ite Tracking And Recruitment). The introduction of...e selection process as it automates the study feas...start-up phase. The resulting system delivers solu...
...ming and playing in the backyard , , NORTHBROOK,...be trying to beat the heat - and recession - by sw...yard play set or pool and restricting dining out t.... , , With nearly half of all unintentional chil...
...s Optical, Inc.,today announced that Hispanics wil...levant information about eye health issues through...one users will have the option to subscribe to,rec...ight messages will be sent to Hispanics along with...
...ap.com ), a premier co-location facility, today ...signs. , , As a strategic initiative to consolida...ty coupled with a need for a true Tier III facilit...elational pharmacy and medical claims database, wh...
... prominent father of child with type 1 diabetes to...ry , , BOSTON, May 18 Joslin Diabetes Center tod...star guard Ray Allen to its Board of Trustees. Al...hampions, Allen,s son Walker, 2, was diagnosed wit...
Other Medicine News:Health News:Verizon Employees at Five Locations in West Virginia Donate Nearly $7,000 Worth of Household Items to Local Domestic Violence Shelters 2Health News:ACORN CRO Launches STAR (Site Tracking and Recruitment) 2Health News:Underwriters Laboratories Reminds Parents to Pay Attention to 'Staycation' Safety Hazards 2Health News:Underwriters Laboratories Reminds Parents to Pay Attention to 'Staycation' Safety Hazards 3Health News:SMS Technology Places Eye Health Educational Information at Hispanics' Fingertips 2Health News:GNAX/AtlantaNAP Announces Newest Client, Health Information Designs 2Health News:Joslin Diabetes Center Names Boston Celtics Star Ray Allen to Board of Trustees 2
(Date:11/26/2009)..., , JOHANNESBURG, South Africa, Nov. 26...th Africa Company of the Year Award in the Generic...o South Africa Limited. ,, (Logo: http://www.n...r the Company of the Year Award, the following cri...mance against key competitors: growth strategy and...
(Date:11/25/2009)..., , PRINCETON, N.J., Nov. 25 /PRNewswire-F...clinical stage pharmaceutical company committed to... drugs to treat viral infections, reported financi... 2009. At September 30, 2009 Pharmasset held $58.4...investments. ,, Pipeline Update and 2009 High...
(Date:11/25/2009)..., , WEST PALM BEACH, Fla., Nov. 25 /PRNew...aring impaired Americans, especially the 27 millio...ys may not be all that happy, says audiologist Cin...f HearUSA (Amex: EAR ), one of America,s largest ...udies have linked hearing loss to stress, frustrat...
Breaking Medicine Technology:Frost & Sullivan Award Underlines Cipla Medpro's Status as Company of the Year in the South African Generic Pharmaceutical Market 2Frost & Sullivan Award Underlines Cipla Medpro's Status as Company of the Year in the South African Generic Pharmaceutical Market 3Frost & Sullivan Award Underlines Cipla Medpro's Status as Company of the Year in the South African Generic Pharmaceutical Market 4Pharmasset Reports Fiscal Year End 2009 Financial Results 2Pharmasset Reports Fiscal Year End 2009 Financial Results 3Pharmasset Reports Fiscal Year End 2009 Financial Results 4Pharmasset Reports Fiscal Year End 2009 Financial Results 5Pharmasset Reports Fiscal Year End 2009 Financial Results 6Pharmasset Reports Fiscal Year End 2009 Financial Results 7Pharmasset Reports Fiscal Year End 2009 Financial Results 8Pharmasset Reports Fiscal Year End 2009 Financial Results 9Pharmasset Reports Fiscal Year End 2009 Financial Results 10For Millions With Untreated Hearing Loss, Holiday Season Can be Especially Difficult 2For Millions With Untreated Hearing Loss, Holiday Season Can be Especially Difficult 3Nanodiamonds deliver insulin for wound healing 9376 1Nanodiamonds deliver insulin for wound healing 9376 2Nanodiamonds deliver insulin for wound healing 9376 3Placenta derived stem cells may help sufferers of lung diseases 9373 1Placenta derived stem cells may help sufferers of lung diseases 9373 2ISU researchers find possible treatment for spinal muscular atrophy 9370 1ISU researchers find possible treatment for spinal muscular atrophy 9370 2
...dding Bavituximab to Standard Regimen of Androgen ...erly Resistant Tumors by More than Half - - Data...e Multiple Combination Regimens for ...pt. 7 ,Peregrine Pharmaceuticals, Inc. (Nasdaq: P...developing targeted monoclonal antibodies for the,...
...HASSET, N.Y., Sept. 6 Scientists at The,Feinstein...critical gene,that increases a person,s risk for r...us, and may be involved with other autoimmune dise...r 6th issue of the New,England Journal of Medicine...rsen, MD, head of The Feinstein Institute,s Robert...
Other Medicine Technology:Peregrine Reports Data Showing Bavituximab's Potential to Shrink Prostate Tumors 2Peregrine Reports Data Showing Bavituximab's Potential to Shrink Prostate Tumors 3Peregrine Reports Data Showing Bavituximab's Potential to Shrink Prostate Tumors 4New Risk Gene for Rheumatoid Arthritis and Lupus Opens Door to More Effective Treatments 2New Risk Gene for Rheumatoid Arthritis and Lupus Opens Door to More Effective Treatments 3New Risk Gene for Rheumatoid Arthritis and Lupus Opens Door to More Effective Treatments 4
... national reference laboratory and a worldwide lea...ent. ARUP offers an extensive test menu of highly ...natomic pathology. Owned by the University of Utah...f of the nation's university teaching hospitals an...
... national reference laboratory and a worldwide lea...ent. ARUP offers an extensive test menu of highly ...natomic pathology. Owned by the University of Utah...f of the nation's university teaching hospitals an...
... national reference laboratory and a worldwide lea...ent. ARUP offers an extensive test menu of highly ...natomic pathology. Owned by the University of Utah...f of the nation's university teaching hospitals an...
... national reference laboratory and a worldwide lea...ent. ARUP offers an extensive test menu of highly ...natomic pathology. Owned by the University of Utah...f of the nation's university teaching hospitals an...
Medicine Products: