Navigation Links
Porous structures help boost integration of host tissue with implants, study finds
Date:1/30/2008

NEW YORK Results published today in FASEB (the journal of the Federation of American Societies for Experimental Biology) by researchers at Columbia University, including Jeremy Mao of the Columbia College of Dental Medicine, demonstrate a novel way of using porous structures as a drug-delivery vehicle that can help boost the integration of host tissue with surgically implanted titanium.

Instead of being acted upon by the body as an impenetrable foreign object, the synthetic bone replacement currently being tested in rabbits features a porous material that allows for the delivery of microencapsulated bioactive cues that speed up the growth of host tissue at the site and allow for the growth of new bone.

A critical finding is that the drug dose needed for host tissue integration by this controlled-release approach is about 1/10 of that by the traditional technique of simple adsorption of the growth factor.

The approach could bring to orthopedics and dentistry a treatment that has wrought much interest and success in the field of cardiology with the development of drug-eluting stents, which take what is ordinarily an inert tube, and infuse it with drugs to make the placement of what is essentially a man-made, foreign object more compatible with the patients body, and at the same time, actively promoting healing of injured tissue.

After just four weeks, the porous implants that Mao and his team are using showed a 96 percent increase in bone-to-implant contact and a 50 percent increase in the growth of new bone over placebos.

How were such results achieved?

Since stem cells play a vital role in the growth of new bone, Mao and his team have focused on impregnating the titanium implants with a factor that homes the bodies own regenerating cells to the potential growth site to create and build on a platform for new bone.

The new approach may in the future obviate the need to harvest bone from a non-injured site in the body for grafting into the site of injury, as commonly performed now. This strategy, although often effective, creates additional wounds. The work of Mao and his team suggests that it should be possible to harnesses the bodys natural tissue regeneration capacity to recruit the right cells to the site where new bone tissue is needed. Implants that naturally attract the mesenchymal stem cells that can readily differentiate into bone, fat, cartilage and other types of cells could be the way of the future, Mao says. In comparison with donor site morbidity and pain in association with autologous tissue grafting, synthetic materials have the advantage of ready and endless supply without any sacrifice of donor tissue, he says.

The approach also overcomes a practical obstacle confronting many orthopedic surgeons.

This is a hybrid approach releasing biological cues from existing orthopedic and dental implants to recruit the bodys own stem cells. Its unrealistic, at least from what we know now, to build a cell culture room next to every operating room, Mao added. Using these types of porous implants doesnt require physicians to deliver stems cells so much as it allows the patients body to send its own cells to the right place.


'/>"/>

Contact: Alex Lyda
mal2133@columbia.edu
212-305-0820
Columbia University Medical Center
Source:Eurekalert

Related medicine news :

1. Smart insulin nanostructures pass feasibility test, UT study reports
2. Pharmos Restructures Operations in Israel
3. Health Capital Group Warns of Fallout to Hospitals From the Subprime Mortgage Crisis and Urges Hospitals to Immediately Reassess Existing Debt Structures and Capital Financing Plans
4. New treatment boosts muscle function in myasthenia gravis
5. Heavy Drinking Boosts Stroke Risk for Chinese Men
6. Longer ambulance journeys boost death risk for seriously ill patients
7. Traffic Fumes Plus Genes Boosts Kids Asthma Risk
8. Heart Attack Boosts Diabetes Risk
9. Smoking Boosts Risk for Head, Neck Cancers
10. Continued Statin Use Boosts Post-Stroke Outcomes
11. U.S. Initiative Seeks to Boost Hispanic Stroke Awareness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... February 11, 2016 , ... According to an article published February ... loss dietary supplement, is being recalled due to the discovery that it contains dangerous ... not a single supplement on the market proven to help people safety lose excess ...
(Date:2/11/2016)... , ... February 11, 2016 , ... Registered nurses, licensed ... CEU seminar titled, “Stroke Management: Time to Act, Time to Heal” on Thursday, February ... in Whippany, N.J. The presenter is Vishal Chedda, president of ANSA Consultants, who will ...
(Date:2/11/2016)... (PRWEB) , ... February 12, 2016 , ... The ... is up from 0.416 in 2013. The SJR uses data taken from the Scopus ... account both the number of citations received by the journal over a three year ...
(Date:2/11/2016)... ... 11, 2016 , ... The Chartis Group, a national advisory ... in the “2015/2016 Best in KLAS: Software and Services” report in two categories: ... and insights firm on a global mission to improve healthcare delivery by amplifying ...
(Date:2/11/2016)... ... February 11, 2016 , ... Thermi™, a world leader ... to announce the promotions of Allison Kelly to executive vice president of the ... vice president of North American capital sales, and Wendy Oseas to vice president ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... SAN FRANCISCO , Feb. 11, 2016 Potrero ... system, is pleased to announce the appointment of George ... San Antonio, TX , WellMed is ... servicing over 200,000 patients and HMO members in ... founding WellMed in 1990 out of his own internal medicine ...
(Date:2/11/2016)... Feb. 11, 2016  MiMedx Group, Inc. (NASDAQ: ... amniotic membrane and other birth tissues, human skin and ... and market advanced products and therapies, announced today that ... Global Healthcare Conference in New York ... Michael J. Senken , Chief Financial Officer and ...
(Date:2/11/2016)...  AfterPill.com is reporting that this week,s Centers for ... women who are at risk of unintended pregnancy impacts ... raises the risks of unprotected sex in particular.  ... to the Guttmacher Institute, there are 43 million women ... who have sex without the intention of becoming pregnant.  ...
Breaking Medicine Technology: