Navigation Links
Popular diabetes drugs associated with fractures in type 2 diabetic patients
Date:7/29/2010

Postmenopausal women with diabetes taking thiazolidinediones (TZDS), including rosiglitazone and pioglitazone, may be at increased risk for fractures according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Men with diabetes taking both loop diuretics and TZDs may also be at increased risk of fractures.

"Our study shows that increased fracture risk is associated with higher TZD dose, but no difference between rosiglitazone and pioglitazone is apparent suggesting a class effect of TZDs on fracture risk," said William Herman, MD, MPH, of the University of Michigan in Ann Arbor and senior author of the study. "Physicians should be aware of this risk and weigh the benefits and risks of therapy when they initially prescribe or renew prescriptions for TZDs."

Using data from Translating Research into Action for Diabetes (TRIAD), a multi-center prospective observational study of diabetes care in managed care, researchers conducted a matched case-control study to assess the odds of TZD exposure in patients with type 2 diabetes with and without fractures. From the study, researchers identified 786 cases of fractures and 2,657 matched controls (diabetes patients without fractures).

Women aged 50 years and older with fractures, when compared to their matched controls, were significantly more likely to have filled prescriptions for TZDs. Men with fractures were more likely to have filled prescriptions for TZDs and loop diuretics when compared to their matched controls. This result is particularly interesting because in men, loop diuretics or TZDs alone did not confer significant risks.

"Future studies, particularly long-term, prospective randomized clinical trials will be needed to conclusively demonstrate small to moderate harm," said Herman.


'/>"/>

Contact: Arlyn Riskind
ariskind@endo-society.org
301-941-0240
The Endocrine Society
Source:Eurekalert

0

GOOD

Page: 1

Related medicine news :

1. New research finds no evidence that popular slimming supplements facilitate weight loss
2. Iceland -- Working on its Popularity for Travellers, Iceland ProTravel Supports Ad Campaign "Inspired by Iceland"
3. SDI Reports: Roughly Half of Patients Prescribed the Most Popular Osteoporosis Drugs Discontinue Therapy Within 6 Months -- Amgen's Prolia Offers New Dosing Option
4. New iPhone App “Wing Chun Masters” Brings 400-Year-Old Kung Fu To Life Amidst Renewed Popular Interest In Culture.
5. University of Pennsylvania: Contrary to popular models, sugar is not burned by self-control tasks
6. Popular cancer drug can cause kidney damage
7. Certain Popular Antidepressants Linked to Cataracts in Seniors
8. As Popularity of Dental Implants Rise, a Chicago Cosmetic Dentistry Practice's On-site Lab Offers Patients a Unique Incentive
9. Shoot 1UP, Popular Xbox 360 Action Game, Updated for Disabled Gamers
10. FDA Warns of Fracture Risk With Popular Heartburn Drugs
11. Med Spa Treatments Become More Popular as Unemployment Rates Climb
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2013)... Orlando, FL (May 18, 2013) The use ... for a colonoscopy, according to new research presented ... process, which begins days in advance of the ... preparation medication to be taken at strict intervals. ... for doctors to see cancer and precancerous polyps ...
(Date:5/18/2013)... of coffee is associated with a reduced risk ... disease, Mayo Clinic research shows. The findings were ... conference in Orlando, Fla. , PSC is ... results in inflammation and subsequent fibrosis that can ... and biliary cancer. , "While rare, PSC has ...
(Date:5/18/2013)... Hayden, ID (PRWEB) May 18, 2013 ... needs when it comes to safety and comfort ... these requirements and provides clients with an effective ... System®. This is an integrated, turnkey communications ... of care, while allowing residents independence and privacy. ...
(Date:5/18/2013)... Utah (PRWEB) May 18, 2013 ... on insurance agents’ role in Marketplaces . ... to traditional employer sponsored health benefits, is the ... and health reimbursement arrangements . , ... Health and Human Services (HHS) recently released a ...
(Date:5/18/2013)... Springs, FL (PRWEB) May 18, 2013 The ... dedicated to the special places we call home. These are ... on maps. They are the locations where the people are ... first-rate show takes viewers off the highways and shares the ... best of both nations with an American sports and film ...
Breaking Medicine News(10 mins):Health News:New smartphone application improves colonoscopy preparation 2Health News:VisionLink Nurse Call System's New Features Serve the Unique Needs of Retirement Communities 2Health News:VisionLink Nurse Call System's New Features Serve the Unique Needs of Retirement Communities 3Health News:Zane Benefits Publishes New Information on Insurance Agents’ Role in Marketplaces 2Health News:Zane Benefits Publishes New Information on Insurance Agents’ Role in Marketplaces 3Health News:Zane Benefits Publishes New Information on Insurance Agents’ Role in Marketplaces 4Health News:Communities of Distinction TV Presents "A Place to Call Home" Segment 2
... the seat of the Polish government Friday in support of ... of the building in a two-week pay protest. ... Silesian coal belt, brandished banners reading, "We want a decent ... ,Ringed by riot police, the demonstrators mingled with ...
... more likely to suffer heart attacks, according to a ... Bhopal and Colin Fischbacher at the University of Edinburgh, however, ... in comparison to their non-Asian countrymen. ,As part ... groups from the 2001 Census to Scottish hospital discharge and ...
... Britney Spears has openly confessed that she had sex with former ... until she was married. ,"I've only slept with ... into my relationship with Justin, and I thought he was the ... a magazine The most painful thing I have ever experienced ...
... the web are all pass, for the latest way to bag ... ,This new trend is a blessing for many singleton smokers ... a cigarette. ,This blend of smoking and flirting developed ... introduced, reports The Sun. ,The Irish were the first ...
... identified one unifying principle that could explain how a range ... for the cause of depression has implicated so many suspects ... condition remains an enigma. ,They found that ... treatment in the end appear to funnel through a single ...
... Saturday announced new measures aimed at curbing an epidemic ... prove elusive . ,China plans to set ... by the end of the year and to implement ... was quoted by the official Xinhua news agency as ...
Cached Medicine News:Health News:Trade Unionists Join Polish Nurses' Protest 2Health News:Brain Pathway for Depression Revealed 2Health News:Brain Pathway for Depression Revealed 3Health News:Top China Official Pessimistic on Fixing Food Safety Woes 2
(Date:5/17/2013)... 17, 2013 Research explores ... outcomes research also   to   be presented ... SHPG ), the global specialty biopharmaceutical company, announces that ... at the American Psychiatric Association (APA) 166th Annual Meeting ... The data being presented represent Shire,s ongoing commitment to ...
(Date:5/17/2013)... /PRNewswire-iReach/ -- The escalation of new biological drugs, ... emphasis on alternate delivery technologies. Alternate delivery technologies ... factors are converging to create both risk ... device partners . These include new classes of ... toward self-administration for chronic diseases, shifting patient demographics ...
(Date:5/17/2013)...  Boehringer Ingelheim will contribute to advancing the ... Thoracic Society International Conference (ATS 2013) in ... 22. Data will highlight research conducted ... chronic obstructive pulmonary disease (COPD) [Spiriva® HandiHaler® (tiotropium ... for asthma, idiopathic pulmonary fibrosis (IPF) and COPD. ...
Breaking Medicine Technology:Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 2Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 3Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 4Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 5Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 6Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 7Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 8Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 9Shire to Present Scientific Data Across a Range of Psychiatric Disorders at American Psychiatric Association Annual Meeting 10Pharmaceutical Makers and Delivery Device Partners Rethink Delivery Technologies - New Report Examines this Evolving Segment 2Pharmaceutical Makers and Delivery Device Partners Rethink Delivery Technologies - New Report Examines this Evolving Segment 3Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 2Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 3Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 4Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 5Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 6Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 7Boehringer Ingelheim to Present 17 Abstracts at the Annual American Thoracic Society International Conference 8
A "doughy" type of bone cement intended for manual application....
... The Videoscopes provide superior image quality ... to the camera head with a ... ensures more light at the operative ... optimum image clarity and reliability.,The Videoscopes ...
... a wide range of innovative features, including ... Control (U.S. Patent #4,684,227). Stereopsis is maximized ... Heine's unique Diffuser aperture absorbs only 30% ... and simplifying difficult examinations. A newly incorporated ...
... 3-wire patient cable and 4 ... of the unit. 3-step procedure enabling ... 8 or 12 lead ECG through ... position. Records 2.5 seconds per lead ...
Medicine Products: