Navigation Links
Popular diabetes drug works differently than thought
Date:5/4/2010

CINCINNATIThe popular diabetes medication metformin works in different fashion than the current widely accepted view. This new finding could lead to wider use of the drugparticularly in people with cancer and diseases linked to TSC deficiency like tuberous sclerosis and lymphangioleiomyomatosis (LAM).

The results of this study, led by George Thomas, PhD, scientific director of UC's Metabolic Diseases Institute, are published in the May 5 edition of Cell Metabolism.

Metformin, marketed first by Bristol-Myers Squibb as Glucophage and now available in generic form and a number of combinations, is widely prescribed to people with type 2 diabetes and may be extended to the treatment of certain cancers. The drug blocks the production of glucose (sugar) and increases sensitivity to insulina hormone that converts sugar and other foods into energy within the body.

Researchers have thought that metformin, an energy-deprivation agent, disables the mTOR (mammalian target of rapamycin) complex by first activating the tuberous sclerosis complex (TSC) proteins through the enzyme AMPK.

Thomas' team determined that mTOR could actually be disabled without AMPK, and even without TSC. The team was able to determine that metformin works to knock out mTOR through another enzyme, RAG GTPase.

"We've poked a hole in dogma," says Thomas, a professor in the cancer and cell biology department. "Scientists can and should go back and ask about things they had crossed off their list."

The importance of this finding, says Thomas, is the possibility it holds for broader use of metformin.

"Metformin is already prescribed to 100 million people worldwide, and our study raises the question, 'Could this drug be used even more widely?'"

A drug like metformin, which improves insulin sensitivity, could be seen as a possible viable alternative to drugs that target mTOR, but that may have long-term deleterious effects on insulin production. Type 2 diabetes results from the body's inability to properly use insulin. If left unmanaged, diabetes can lead to vision loss, kidney failure, heart attack, stroke and nerve or blood vessel damage.


'/>"/>

Contact: Dama Kimmon
dama.kimmon@uc.edu
513-558-4519
University of Cincinnati Academic Health Center
Source:Eurekalert

Related medicine news :

1. The Diet Solution Program: Popular Online Weight Loss Program is Revised to Include More Metabolism Boosting Meals
2. Quantity, Not Quality, of Online Posts Builds Popularity
3. Passover paradox: The amazing popularity of kosher foods
4. Electronic Cigarettes Continue to Experience Popularity Growth
5. Future Apps Releases Major Update to its Popular iPhone Text to Speech App Speak it
6. "How Stupid Do They Think We Are?" --- Band Releases New Anthem in Support of Popular Citizens' Resistance
7. Intellimed's Popular Data Reporting Software IM-IC (Intelligent Client) Receives Latest Update
8. Personalized Live on-Demand Yoga Avatar Gains Popularity Amongst Users, Across all age Groups
9. Popular nanoparticle causes toxicity in fish, study shows
10. Popular Diet Plans Can Unclog Arteries
11. Americans Remain Split on Stalled Health Care Legislation, but Some Provisions Popular Among Majorities of Democrats, Independents and Republicans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... ... , ... The Santana Telehealth Project was honored with the 2017 ATA Humanitarian ... Association’s annual conference, on April 23 in Orlando, FL. , “I am proud that ... of the poor and underserved in other parts of the world,” said Jonathan Linkous, ...
(Date:4/24/2017)... ... April 24, 2017 , ... ... Association’s Outstanding Public Communication of Education Research Award. The award honors scholars exemplary ... communities. It recognizes a scholar who has demonstrated the capacity to deepen the ...
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... The California ... million in charitable dental services to 1,961 people during the April 22-23 event at ... no charge to Californians who experience barriers to care, CDA Cares educates the public ...
(Date:4/24/2017)... , ... April 24, 2017 , ... The John P. ... technology that allows anyone, anywhere to track their cognitive health, and share results with ... their own brain health on the museum's website. , BrainCheck founder, Dr. David Eagleman, ...
(Date:4/24/2017)... ... , ... My T Chai, a South African company that creates a number ... RevNutrition.com, a popular website specializing in sales of nutritional products. , Chai tea ... Siam. It spread across Asia and Africa quickly, and today recipes vary from region ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... provides evidence that an old drug may provide relief for ... that will be presented at the American Academy of ... , April 22 to 28, 2017. When ... drug levodopa has long been considered the gold standard, improving ... the effects of the medication can partially wear off more ...
(Date:4/18/2017)... , April 18, 2017 Cogentix Medical, ... on providing the Urology, Uro/Gyn and Gynecology markets with ... the first quarter ended March 31, 2017 after the ... The Company will host a conference call and ... on Tuesday, May 2, 2017 at 4:30 p.m. Eastern ...
(Date:4/18/2017)... and BLOOMINGTON, Minn. ... (NASDAQ: IMMY ) ("Imprimis"), an ophthalmology-focused ... Lens ("Precision Lens"), today announced the signing of ... agreement, Precision Lens will deploy a dedicated sales ... geographies in the U.S., primarily focused in 13 ...
Breaking Medicine Technology: