Navigation Links
Popular colorectal cancer drug may cause permanent nerve damage
Date:9/28/2011

Oxaliplatin, a platinum-based anticancer drug that's made enormous headway in recent years against colorectal cancer, appears to cause nerve damage that may be permanent and worsens even months after treatment ends. The chemotherapy side effect, described by Johns Hopkins researchers in the September issue of Neurology, was discovered in what is believed to be the first effort to track oxaliplatin-based nerve damage through relatively cheap and easy punch skin biopsies.

The Johns Hopkins investigators emphasize that the drug therapy clearly improves length of survival in advanced cancer by months to years, and that the goal of their new study is to find ways of preventing or slowing the damage through nerve-protective therapies identfied through simple skin testing.

Many patients who take oxaliplatin report bothersome neurological side effects, including pain in the hands and feet and a numbness or tingling in the throat that affects swallowing, according to study leader Michael Polydefkis, M.D., M.H.S., associate professor of neurology at the Johns Hopkins University School of Medicine and director of the EMG Laboratory and Cutaneous Nerve Laboratory at Johns Hopkins Bayview Medical Center. Though these symptoms develop over time in the majority of patients, some report neuropathies as early as when the drug is first infused.

To get a better sense of how oxaliplatin affects nerve cells, Polydefkis and his colleagues recruited eight cancer patients about to begin oxaliplatin treatment at The Johns Hopkins Hospital. All had been diagnosed with advanced colon cancer.

Before their first oxaliplatin infusion, each patient underwent a comprehensive neurological examination, including nerve conduction testing, a clinical exam to look for signs of nerve damage, and a punch biopsy that removed tiny (3-mm diameter) portions of skin near their knees and ankles. Once oxaliplatin treatment began, consisting of infusions over two da
'/>"/>

Contact: Christen Brownlee
cbrownlee@jhmi.edu
410-955-7832
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Popular Diabetes Drugs May Raise Pancreatic Cancer Risk, Study Suggests
2. Study finds popular muscle-boosting supplement does not increase blood flow
3. Popular mammography tool not effective for finding invasive breast cancer
4. Internal bleeding higher with popular heart device than earlier model
5. Popular Blood Pressure Meds Not Linked to Cancer, FDA Says
6. Care for a spot of (green) tea? New NIST reference materials for popular diet supplement
7. Popular Heartburn Meds May Boost Fracture Risk
8. Contrary to popular belief, not all cases of chronic pancreatitis are alcohol-induced
9. Popular Baby Media May Not Actually Advance Learning
10. Popular drugs for common male health problems can affect their sexual health
11. Popular Bone Drugs Linked to Reduced Colon Cancer Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... (PRWEB) August 23, 2014 Youth substance ... Texas. It’s no different in Houston, TX. Substance abuse ... falling victim to drug and alcohol dependency in higher ... looking to beat substance abuse, but don’t know where ... treatment facility can be a challenge because most treatment ...
(Date:8/23/2014)... 23, 2014 Teen substance abuse ranks as ... Holly Springs, NC. Countless adolescents throughout North Carolina struggle with ... Unfortunately, many never receive professional rehab due to a lack ... to get help. Troubled Teens Holly Springs is a helpline ... local teenage alcohol abusers in Wake County who ...
(Date:8/22/2014)... August 23, 2014 Search Engine ... the first page of search engines and get ... Hosting has recently compared many Linux hosting suppliers ... Bluehost are the most recommended Linux hosting suppliers ... and Europe to buy high quality Linux hosting ...
(Date:8/22/2014)... 2014 Deep Research Report on ... in-depth research report on the Glucose Meter market. ... Glucose Meter definition, classification, application, and industry chain ... covers the international market analysis, including domestic market ... environment & economic situation analysis. The report on ...
(Date:8/22/2014)... Recently, Skmen.com, an experienced supplier of ... bohemian dresses in its online store. Moreover, all these ... to 28% off. All the international clients can obtain ... 2014. , The company’s professional online workers update ... worldwide customers more the latest information about its new ...
Breaking Medicine News(10 mins):Health News:New Houston Hotline Assisting Juveniles in Locating Dependable Rehabilitation Help 2Health News:New Helpline Provides Teen Drug & Alcohol Recovery Information in Holly Springs, NC 2Health News:Top10BestSEOHosting.com Announces Best Cheap Hosting Suppliers Of This Summer 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 3Health News:Cheap Bohemian Dresses Unveiled by Experienced Supplier Skmen.com 2
... ACNE TREATMENT EMBRACES DIFFERENCES IN MEN,S,AND WOMEN,S SKIN BY ... TREATMENT SOLUTION, SUMMIT, N.J., Oct. 30 Here,s ... between men and women are no more than skin,deep. ... care product, each,gender will be able to address these ...
... DENVER, Oct. 30 Air Methods Corporation,(Nasdaq: AIRM ) announces the ... Webcast, When: November 6, 2008 @ 4:15 ... Live over the Internet -- Simply log ... address above., Contact: Christine Clarke ...
... common gene variations may be responsible for much of ... New research on the MYH9 geneand its implications for ... the African American populationwill be summarized in a press ... Nephrology,s 41st Annual Meeting and Scientific Exposition in Philadelphia, ...
... Many with Eating Disorders, PHOENIX, Oct. 30 ... disorders are worried about treatment and not,seeking the help ... help for an eating disorder can be very,serious because ... Wall, PhD, director of psychological services at Remuda Ranch,Programs ...
... - Expands Therapy to Broader Patient Population -, ... Inc.,(NYSE: HSP ), a global specialty pharmaceutical ... Food and Drug Administration (FDA),approved a new indication ... This approval allows for use of Precedex in,non-intubated ...
... on a wide range of patient treatment experiences ... and features of ... Altrazeal(TM) -, LAS VEGAS, Oct. 30 ULURU ... application of Altrazeal(TM) -,Transforming Powder Dressing were presented yesterday at a special session,of ...
Cached Medicine News:Health News:Finally ... A Chance for Both Men and Women to Take CTRL(TM) of Their Own Skin! 2Health News:Finally ... A Chance for Both Men and Women to Take CTRL(TM) of Their Own Skin! 3Health News:MYH9 gene variations help explain high rate of kidney disease in African-Americans 2Health News:MYH9 gene variations help explain high rate of kidney disease in African-Americans 3Health News:MYH9 gene variations help explain high rate of kidney disease in African-Americans 4Health News:Remuda Ranch Reports Many Individuals With Eating Disorders Are Not Getting Help They Need 2Health News:FDA Approves New Indication for Hospira's Precedex (Dexmedetomidine HCL) Injection 2Health News:FDA Approves New Indication for Hospira's Precedex (Dexmedetomidine HCL) Injection 3Health News:FDA Approves New Indication for Hospira's Precedex (Dexmedetomidine HCL) Injection 4Health News:ULURU Inc. Hosts Symposium on Altrazeal(TM) at the 23rd Annual Clinical Symposium on Advances in Skin & Wound Care 2Health News:ULURU Inc. Hosts Symposium on Altrazeal(TM) at the 23rd Annual Clinical Symposium on Advances in Skin & Wound Care 3
(Date:8/22/2014)... On Aug. 20, at its annual meeting in ... voted on and approved a delegate resolution opposing the ... Cannabis Corp., a leading Canadian licensed producer of medicinal ... The CMA is quite right to point out that ... material, including medicinal cannabis. While some patients, particularly those ...
(Date:8/22/2014)... Equity Research highlights Epizyme (Nasdaq: EPZM - Free Report ... PNRA - Free Report ) as the Bear of the Day. ... FOLD - Free Report ), Sanofi (NYSE: SNY - ... ). Here is a synopsis of all five stocks: ... The biotech bull market is far from over due to ...
(Date:8/22/2014)... , Aug. 22, 2014  Cannabis Science, Inc. ... formulation-based drug development and related consulting, is pleased ... international medical cannabis conference taking place at the ... , on October 22, 2014.  The multilingual ... such as researchers, health professionals, and patients, to ...
Breaking Medicine Technology:Bedrocan Canada Statement Regarding Canadian Medical Association Motion on Smoking Marijuana 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 2Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 3Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 4Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 5Epizyme, Panera, Amicus Therapeutics, Sanofi and Shire highlighted as Zacks Bull and Bear of the Day 6Cannabis Science, Inc. (CBIS) to Sponsor 3rd International Conference on Cannabinoids in Medicine in October 2014 in Strasbourg, France 2Cannabis Science, Inc. (CBIS) to Sponsor 3rd International Conference on Cannabinoids in Medicine in October 2014 in Strasbourg, France 3
... ARBOR, Mich., Nov. 9 Thomson Reuters ... a leading clinical surveillance solution that enables hospitals to ... improve clinical quality and reduce total cost of treatment. ... at no additional cost. , CareFocus 2.0 ...
... Nov. 9 Arcadia Resources, Inc. (NYSE Amex: ... care services under the Arcadia HealthCare(SM) brand, has appointed ... will replace Tres Lund who announced his resignation from ... http://www.newscom.com/cgi-bin/prnh/20091109/DE07521 ) , Goldsmith is the Daniel ...
Cached Medicine Technology:Thomson Reuters Clinical Surveillance Solution Offers Powerful New Functionality to Improve Clinical Quality and Reduce Costs 2Thomson Reuters Clinical Surveillance Solution Offers Powerful New Functionality to Improve Clinical Quality and Reduce Costs 3Arcadia Resources Names Stephen Goldsmith to Board of Directors 2Arcadia Resources Names Stephen Goldsmith to Board of Directors 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: