Navigation Links
Popular cancer drug can cause kidney damage
Date:6/10/2010

The widely used cancer drug bevacizumab may cause severe loss of protein from the kidney into the urine that can lead to significant kidney damage and can compromise the efficacy of cancer treatment, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The results suggest that physicians should monitor patients' kidney health when prescribing this angiogenesis inhibitor.

While research indicates that treatment with the chemotherapy drug bevacizumab can lead to urinary protein leakage (proteinuria) and kidney damage, the overall risk associated with the drug and patient risk factors are unknown. Bevacizumab blocks a protein called vascular endothelial growth factor, thus inhibiting the production of new blood vessels around tumors.

Shenhong Wu MD, PhD (Stony Brook University Cancer Center), Xiaolei Zhu, MD, PhD (Kidney Doctors PLLC), and their colleagues conducted a review of published randomized, controlled clinical trials to assess the overall risk for severe proteinuria in patients taking bevacizumab. The researchers analyzed data from 16 studies comprising 12,268 patients with a variety of tumors.

Severe proteinuria occurred in 2.2% of patients taking bevacizumab. Compared with patients taking chemotherapy alone, patients taking bevacizumab combined with chemotherapy had a 4.79-fold increased risk of developing severe proteinuria and a 7.78-fold increased risk of developing nephrotic syndrome. (Nephrotic syndrome is a group of symptoms including protein in the urine, low blood protein levels, high cholesterol levels, high triglyceride levels, and swelling.)

Patients taking higher dosages of bevacizumab had the greatest risk of developing proteinuria. Also, when the investigators looked at differences by cancer type, they found that patients with kidney cancer had the highest risk of developing proteinuria (10.2% incidence).

These results indicate that it is particularly important to monitor the effects of bevacizumab in patients who have kidney cancer or who are receiving high doses of the drug. Future studies should investigate how to reduce bevacizumab's kidney-related effects, and physicians should be prepared to treat these potential side effects.


'/>"/>

Contact: Shari Leventhal
sleventhal@asn-online.org
202-416-0658
American Society of Nephrology
Source:Eurekalert

Related medicine news :

1. Wii Popularity Leads to New Kind of Gaming Injury
2. Presidents As Popular as a Root Canal Comment Misses Mark
3. Religion a Popular Topic of Discussion Among US Physicians on Sermo
4. Urinary Incontinence Rates Increase Worldwide As Awareness Grows About Treatment Options: Urethral Slings Are Popular Alternatives When Medications Fail
5. Dr. Michael Aziz Releases a New Nutrition Book That Debunks Most Popular Diets and Diet Books
6. Chicago Plastic Surgeon Discusses the Popularity and Safety of Silicone Breast Implants Three Years after FDA Approval
7. Psychology Popular Among College Students
8. Is a Tummy Tuck Right for Me? Alabama Plastic Surgeon Dr. David Durst Offers Tips as the Popularity of Surgical Cosmetic Enhancement Continues to Rise
9. Americans Remain Split on Stalled Health Care Legislation, but Some Provisions Popular Among Majorities of Democrats, Independents and Republicans
10. Popular Diet Plans Can Unclog Arteries
11. Popular nanoparticle causes toxicity in fish, study shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2017)... ... , ... Kevin Harrington, one of the original Sharks from hit reality series Shark Tank, and ... campaign with My Real Earth. , Most people put their healthcare above their skincare, but ... what we put in our bodies. After all, the skin is the largest organ which ...
(Date:7/28/2017)... ... ... For over 20 years Sealy Baby has been creating crib mattresses that ... pride in using some of nature’s best materials while integrating today’s latest comfort technologies ... mattresses and crib bedding for infants and toddlers. We are thrilled ...
(Date:7/27/2017)... ... July 27, 2017 , ... Conventus, New Jersey’s ... physicians, has launched a new educational series of webinars and podcasts to guide ... prescribing of pain medication. The first two episodes of the series, entitled “Pain ...
(Date:7/27/2017)... ... July 27, 2017 , ... Patients with ... in a single office visit from Dr. Alejandro Kovacs. Dr. Kovacs is a ... East Texas patients, including Teeth-in-a-Day® dental implants in Longview, TX. ...
(Date:7/27/2017)... , ... July 27, 2017 , ... ... Verification to State Medicaid programs, Managed Care Organizations and Home Care Agencies, has ... The MEDsys platform, VinCENT, provides technology solutions to over 1,000 agencies and multiple ...
Breaking Medicine News(10 mins):
(Date:7/12/2017)... is a revolutionary new product that relieves painful carpal tunnel syndrome ... affects more than 8 million people a year. Women suffer from ... methods of treating CTS are painful surgery, the use of NSAIDs ... ... a clear patch worn on the palm of the hand. It ...
(Date:7/11/2017)... , July 11, 2017 Zymo Research Corp., also known ... that can quantify biological aging in a precise manner using the myDNAge ... Steve Horvath , a professor of human genetics and biostatistics at the ... School of Public Health , Zymo Research,s proprietary DNAge ™ technology ... ...
(Date:7/11/2017)... Md. , July 11, 2017  The global ... estimated revenues of approximately $394.1 million in 2016.  Although ... trend of solid growth, in particular as a result ... clinical practice, and the recent introduction of a significant ... need for less-invasive testing of tumor biomarkers to guide ...
Breaking Medicine Technology: