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Popular arthritis drug may disrupt heart rhythm, UB research finds
Date:1/24/2008

d animal system for studies on heart in other species, including humans.

When we found an effect on the fly heart, we began looking for the underlying mechanism, said Singh. We searched the fly genome and were surprised to find that these flies dont have cyclooxygenases, the enzymes targeted by Celebrex.

Because the main effect of the drug in our study was induction of arrhythmia, and arrhythmia is often the result of ion-channel dysfunction, continued Singh, we examined the drugs effect on potassium channels and other ion channels in their models and were struck by the strong inhibition of the potassium channels.

The researchers now are examining the underlying molecular mechanisms responsible for the drugs action and its effect on other ion channels that play a prominent role in setting the rhythm of the heart.

We are trying to determine whether the drug binds directly to the channels or to some other molecule, and if it acts by blocking the pore of the channel through which potassium ions travel or by some other mechanism, Singh said.


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Contact: Lois Baker
ljbaker@buffalo.edu
716-645-5000 x1417
University at Buffalo
Source:Eurekalert

Page: 1 2

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