Navigation Links
Poorly contracting uterus in diabetic women increases risk of caesarean birth
Date:12/6/2011

Researchers at the University of Liverpool have found that the strength of uterine contractions in diabetic pregnant women is significantly weaker than in non-diabetic women, increasing the risk of emergency caesarean birth.

In the past 10 years the prevalence of births complicated by diabetes has increased by approximately 50%. There has, however, been very little research undertaken to understand why only a quarter will have a normal vaginal delivery.

Scientists at the University, working with the Liverpool Women's Hospital, studied more than 100 biopsies of the uterus from pregnant women with and without diabetes. They found that contractions in women who had the disease were not as strong as those in non-diabetic women. To understand why this happens the team looked at possible differences in the changes in calcium within the muscle cells, as this is an essential component of uterine contractions.

Calcium levels in the uterus should rise to allow the muscle to contract effectively. Researchers found, however, that in women with diabetes, calcium levels are significantly reduced. Further investigation revealed that the channels in the cell membrane, that are necessary for calcium to enter the cells, were also reduced. This suggests why the uterus may not contract as strongly as it should in women with diabetes.

Uterus tissue in diabetic women also failed to reach the same levels of contractility as in non-diabetic women when stimulated with the drug oxytocin, a commonly used treatment for women experiencing difficult births. The research suggests why so many pregnancies in diabetic women result in an emergency caesarean.

Professor Sue Wray, from the University's Institute of Translational Medicine, said: "In the UK approximately 35,000 pregnant women per year have diabetes and some women develop the condition during pregnancy, a condition called gestational diabetes. We know that more than 60% of these women will need a caesarean section in order to deliver a baby successfully.

"These major operations increase the risk of complications and infection, as well as excessive bleeding and haemorrhage. Up until now we have not known why diabetic women suffer such complicated births, but it is important that more work is done in this field to prevent the further increase in emergency caesarean sections.

"Our work shows that calcium in inhibited from entering the muscle cells. This, together with evidence of reduced overall muscle mass, contributes to a poorly contracting uterus in women with diabetes. Future studies to help diabetic women should now focus on why the condition causes these changes in the first instance and if there is any way to stop it from happening."


'/>"/>
Contact: Samantha Martin
samantha.martin@liv.ac.uk
0044-151-794-2248
University of Liverpool
Source:Eurekalert

Related medicine news :

1. AGH Study Shows High Rates of Poorly Controlled Asthma Among Inner-City Pittsburgh Children
2. Long-acting beta-agonists most effective step-up therapy for children with poorly controlled asthma
3. Poorly understood cell plays role in immunity against the flu
4. Older people in assisted-living facilities sleep poorly
5. Poorly presented risk statistics could misinform health decisions
6. HbA1C test for glucose monitoring poorly predictive in dialysis patients
7. Women, elderly, minorities poorly represented in lung cancer drug trial data submitted to US FDA
8. Special Needs Kids Bullied More, Fare Poorly at School
9. Poorly controlled asthma costly
10. Poorly Controlled Asthma Can Boost Chances of Pregnancy Complications
11. Many Med Schools Score Poorly in Teaching Gay/Lesbian Health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2016)... ... 27, 2016 , ... More than a third of American adults are considered ... surgery has received increased attention in recent years, as an article published ... weight loss, most people are familiar with the basic requirements of maintaining a healthy ...
(Date:5/27/2016)... York, NY (PRWEB) , ... May 27, 2016 , ... ... campaign returns for a third time to shed lights on the variety of topics ... and inspirational stories, “Nurse Appreciation” tackles why this career has gone from being in ...
(Date:5/27/2016)... ... May 27, 2016 , ... In ... the many who are unaware of the plight of aphasia. In collaboration with ... the “Stroke Awareness” campaign. , The link between stroke and aphasia is relatively ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... ... in scholarships to students studying complementary medicine. Allison Outerbridge is this year’s ... her award on May 18 at the university’s Student Leadership Awards ceremony. , ...
(Date:5/26/2016)... , ... May 26, 2016 , ... W.S. Badger ... has been honored with a 2016 When Work Works Award for its use of ... of the national When Work Works project administered by the Families and Work Institute ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)...   , Study met ... bowel cleansing and superiority in , ... of the ascending colon   ... Norgine B.V. today announced new positive data from the phase ... preparation) versus standard 2 litre PEG with ascorbate. The study met ...
(Date:5/24/2016)... May 24, 2016  NxStage Medical, Inc. (Nasdaq: ... on advancing renal care, today announced that Jeffrey ... in the following schedule of investor conferences. Where applicable, ... at http://ir.nxstage.com/ .   ... Conference NY, NY           Friday, June 10, 2016 1:30 ...
(Date:5/24/2016)... HONG KONG , May 24, 2016 ... , the world , s ... and AV fistula intervention   OrbusNeich, a ... solutions, has expanded its portfolio to include products to ... balloons are the company,s first entry devices for lower ...
Breaking Medicine Technology: