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Poor sleep in old age prevents the brain from storing memories
Date:1/27/2013

ate deep sleep, the study found.

The discovery that slow waves in the frontal brain help strengthen memories paves the way for therapeutic treatments for memory loss in the elderly, such as transcranial direct current stimulation or pharmaceutical remedies. For example, in an earlier study, neuroscientists in Germany successfully used electrical stimulation of the brain in young adults to enhance deep sleep and doubled their overnight memory.

UC Berkeley researchers will be conducting a similar sleep-enhancing study in older adults to see if it will improve their overnight memory. "Can you jumpstart slow wave sleep and help people remember their lives and memories better? It's an exciting possibility," said Bryce Mander, a postdoctoral fellow in psychology at UC Berkeley and lead author of this latest study.

For the UC Berkeley study, Mander and fellow researchers tested the memory of 18 healthy young adults (mostly in their 20s) and 15 healthy older adults (mostly in their 70s) after a full night's sleep. Before going to bed, participants learned and were tested on 120 word sets that taxed their memories.

As they slept, an electroencephalographic (EEG) machine measured their brain wave activity. The next morning, they were tested again on the word pairs, but this time while undergoing functional and structural Magnetic Resonance Imaging (fMRI) scans.

In older adults, the results showed a clear link between the degree of brain deterioration in the middle frontal lobe and the severity of impaired "slow wave activity" during sleep. On average, the quality of their deep sleep was 75 percent lower than that of the younger participants, and their memory of the word pairs the next day was 55 percent worse.

Meanwhile, in younger adults, brain scans showed that deep sleep had efficiently helped to shift their memories from the short-term storage of the hippocampus to the long-term storage of the prefrontal cortex.'/>"/>

Contact: Yasmin Anwar
yanwar@berkeley.edu
510-643-7944
University of California - Berkeley
Source:Eurekalert

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