Navigation Links
Poor breast cancer prognosis associated with presence of circulating tumor, cancer stem cells
Date:12/10/2010

San Antonio - Metastatic breast cancer patients whose blood contains circulating tumor cells (CTCs) before or after treatment with high-dose chemotherapy and blood stem cell transplant have shorter survival periods, according to a new study by researchers at The University of Texas MD Anderson Cancer Center in Houston.

The findings were presented today in a poster session at the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium.

In addition, patients with higher percentages of epithelial cells, or the presence of a specific cellular transition, had higher chances for relapse.

"Building on the information from this study, we eventually may be able to use these molecular markers to identify breast cancer patients with a high likelihood of developing metastasis or relapsing. This may allow physicians to design specific treatments to help patients achieve better outcomes," said James M. Reuben, Ph.D., professor in MD Anderson's Department of Hematopathology, and co-corresponding author of the study.

Stem cells have common receptor

High-dose chemotherapy followed by autologous hematopoietic peripheral blood stem cell transplantation (ASCT) offers modest complete response rates for some patients with metastatic breast cancer. However, tumor cells that spread to the bone may be recruited and mobilized along with hematopoietic stem cells to increase a patient's chance of relapse.

"We hypothesized that since the breast tumor cells have the same CXRX4 receptor as hematopoietic stem cells, we might mobilize or recruit tumor cells by using a growth factor proven to mobilize blood stem cells," Reuben said.

Epithelial-to-mesenchymal transition (EMT) is recognized as an important part of metastasis. Epithelial cells line the organs and cavities of the body and usually are not mobile. Mesenchymal cells are mobile and can differentiate into many cell types, for example, to repair injury. EMT has bee
'/>"/>

Contact: Laura Sussman
lsussman@mdanderson.org
713-745-2457
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Trio of drugs may combat triple negative breast cancer
2. Simple fingertip test may identify breast cancer patients at risk for carpal tunnel syndrome
3. FDA Weighs In as Sharing of Breast Milk Booms
4. Bone Drug Zometa Flops Overall as Breast Cancer Treatment
5. Estrogen-Only Hormone Therapy May Reduce Breast Cancer Risk for Some
6. Fox Chase researchers uncover new risk factors for brain metastases in breast cancer patients
7. Certain Breast Cancer Drugs Linked With Heart Risks in Older Women
8. Weight-Lifting After Breast Cancer Wont Cause Lymphedema, Study Finds
9. Weightlifting does not appear to increase risk of arm swelling for breast cancer survivors
10. Weightlifting slashes lymphedema risk after breast cancer treatment
11. Radiation After Surgery Lowers Chances of Breast Cancers Return
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... 31, 2014 Dr. Andrew Lian-Jie Li ... of Dermatology, fellowship trained Mohs surgeon that has been ... , After extensive dermatology research training at the National ... Li completed his internship in internal medicine at the ... Pennsylvania in Philadelphia. Dr. Li pursued further training in ...
(Date:7/31/2014)... prevalence of heroin use has been rising steadily in ... Survey on Drug Use and Health, the number of ... 2007 (373,000) and 2012 (669,000). Emerging evidence suggests the ... who transition from oral and/or intranasal PO use to ... opioid use, and ultimately, heroin injection. This drug-use ...
(Date:7/31/2014)... Model moms are believers. PBS has a ... in the field have grown exponentially in the last two ... industry, there are associated myths that need to be busted. ... Frontier Nursing University . Celebrating 75 years in 2014, Frontier ... in the nation. “Frontier is changing the face of healthcare ...
(Date:7/31/2014)... UK (PRWEB) July 31, 2014 Infection ... the development and maintenance of products in the pharma, ... be performed by using various products and equipment types; ... spoilage of various materials and products. , The ... services is forecast to post a CAGR of about ...
(Date:7/31/2014)... By Amy Norton ... -- They may not have had fast food, TVs or ... arteries -- and a new research review speculates on some ... ancient Egypt, Peru, the Aleutian Islands and the American Southwest, ... of heart arteries from fatty substances that build up, eventually ...
Breaking Medicine News(10 mins):Health News:NJ Top Docs Proudly Presents Approved Provider, Dr. Andrew Li of Warren Skin Care Center 2Health News:NYU CDUHR researchers look at prescription opioid abuse among young adults in NYC 2Health News:NYU CDUHR researchers look at prescription opioid abuse among young adults in NYC 3Health News:Frontier Nursing University Busts Midwifery Myths In Celebration of 75th Anniversary 2Health News:Frontier Nursing University Busts Midwifery Myths In Celebration of 75th Anniversary 3Health News:Frontier Nursing University Busts Midwifery Myths In Celebration of 75th Anniversary 4Health News:Frontier Nursing University Busts Midwifery Myths In Celebration of 75th Anniversary 5Health News:Infection Prevention and Control Market to Post about 7.5% CAGR through 2018, States Infiniti Research in Its Study Published at MarketPublishers.com 2Health News:Infection Prevention and Control Market to Post about 7.5% CAGR through 2018, States Infiniti Research in Its Study Published at MarketPublishers.com 3Health News:No TV or Obesity, But Ancient People Still Had Heart Disease 2Health News:No TV or Obesity, But Ancient People Still Had Heart Disease 3
... group of immature cells that persist in the adult ... mice that these cells undergo dramatic changes in ALS, ... reported November 17 online in Neuron shows that these ... life, eventually morphing into mature nervous system cells called ...
... HealthDay Reporter , WEDNESDAY, Nov. 17 (HealthDay News) -- ... a striking effect on lowering blood pressure in heart ... drugs, Australian researchers report. Although this study only ... -- the authors believe the approach, which involves delivering ...
... Nov. 17 (HealthDay News) -- A new drug focused on the ... clinical trials, new research shows. If eventually approved by ... VX-770 would mark the first treatment that gets at what ... than just the symptoms. Only 4 to 5 percent of ...
... , WEDNESDAY, Nov. 17 (HealthDay News) -- Resistance ... than aerobic exercise and offers other cardiovascular benefits, finds ... University in Boone, N.C., compared blood vessel (vascular) responses ... 10 repetitions of eight resistance exercises and 30 minutes ...
... 17 (HealthDay News) -- The U.S. Food and Drug Administration ... products are illegal. In warning letters to the companies, ... is an "unsafe food additive," and the companies risked further ... find support for the claim that the addition of caffeine ...
... to targeting diseases such as cancer has been announced by ... the potential for more targeted treatments following their identification of ... a human cell. The research teams from Germany and ... Publication on Nature Cell Biology ,s website. ...
Cached Medicine News:Health News:Mysterious cells may play role in ALS 2Health News:Nerve Zap to Kidneys Might Ease Stubborn Hypertension 2Health News:Nerve Zap to Kidneys Might Ease Stubborn Hypertension 3Health News:Drug Targets Faulty Process That Drives Cystic Fibrosis 2Health News:Drug Targets Faulty Process That Drives Cystic Fibrosis 3Health News:Resistance Exercise May Offer Different Cardio Benefits 2Health News:FDA Cracks Down on Caffeinated Alcohol Drinks 2Health News:FDA Cracks Down on Caffeinated Alcohol Drinks 3Health News:Scientists announce new advance with potential for future cancer targeting 2
(Date:7/31/2014)...  Zacks.com announces the list of stocks featured in the ... the latest news and events impacting stocks and the financial ... BIIB - Free Report ), Gilead (Nasdaq: GILD ... Free Report ), AbbVie (NYSE: ABBV - Free Report ... Today, Zacks is promoting its ,Buy, stock recommendations. ...
(Date:7/31/2014)... AUSTIN, Texas , July 31, 2014 Vermillion, ... cancers and women,s health, will hold a conference call on ... discuss results for the second quarter ended June 30, 2014. ... to the call. Vermillion,s Chairman, President and CEO ... a question and answer period. Date: Thursday, August ...
(Date:7/31/2014)... TB Alliance, a not-for-profit with the ... affordable treatments, announced the appointment of Willo ... Mr. Brock comes to TB Alliance having most ... for WWF International (formerly known as the World ... guide the TB Alliance,s resource development, advocacy and ...
Breaking Medicine Technology:The Zacks Analyst Blog Highlights: Biogen, Gilead, Puma Biotechnology, AbbVie and Celgene 2The Zacks Analyst Blog Highlights: Biogen, Gilead, Puma Biotechnology, AbbVie and Celgene 3The Zacks Analyst Blog Highlights: Biogen, Gilead, Puma Biotechnology, AbbVie and Celgene 4The Zacks Analyst Blog Highlights: Biogen, Gilead, Puma Biotechnology, AbbVie and Celgene 5The Zacks Analyst Blog Highlights: Biogen, Gilead, Puma Biotechnology, AbbVie and Celgene 6Vermillion Sets Second Quarter 2014 Conference Call for Thursday, August 14, 2014 2TB Alliance Appoints Willo Brock Senior Vice President, External Affairs 2
... June 14, 2011 Orthopedics This Week announced today ... News to supply Orthopedics This Week, the #1 source ... terminal subscribers including some of the most prominent investors ... The Bloomberg network includes portfolio managers, central bankers, finance ...
... 2011 Pacira Pharmaceuticals, Inc., (Nasdaq: PCRX ... the U.S. Food and Drug Administration (FDA) has extended ... for its review of the New Drug Application (NDA) ... The new PDUFA goal date is October 28, 2011. ...
Cached Medicine Technology:Orthopedics This Week Now on Bloomberg 2Pacira Pharmaceuticals, Inc. Announces FDA Extension of EXPAREL™ PDUFA Target Date by Three Months 2Pacira Pharmaceuticals, Inc. Announces FDA Extension of EXPAREL™ PDUFA Target Date by Three Months 3
Contoured waterfall-front ergonomic seats and generous backrests with lumbar support are standard on these ergonomic chairs. • With casters • With Tubular Base....
Contoured waterfall-front ergonomic seats and generous backrests with lumbar support are standard on these ergonomic chairs. • With casters • With Tubular Base....
... Bench high, 26-31". Ergonomic design increases ... pnuematic control for easy height adjustment. ... allow easy mobility. Fixed footring standard. ... 5000 Volts to technical zero); ...
Inquire...
Medicine Products: