Navigation Links
Poor Sense of Smell May Be Early Sign of Parkinson's

Those with lowest odor identification scores had 5 times greater risk, study finds

FRIDAY, March 28 (HealthDay News) -- An impaired sense of smell could be an early indicator of Parkinson's disease, occurring up to four years before motor skill problems appear, recent research shows.

The study, published in the February issue of the Annals of Neurology, followed 2,267 men who received olfactory testing at the Kuakini Medical Center in Honolulu at least once during two periods in the 1990s. They were followed for up to eight years and, during that time, 35 of the men developed the disease.

An odor identification problem preceded the development of Parkinson's by at least four years in these men. Decreased odor identification was associated with older age, smoking, more coffee consumption, less frequent bowel movements, lower cognitive function and excessive daytime sleepiness, but even after adjusting for these factors, those with the lowest odor identification scores had a five times greater risk of developing Parkinson's than those with the highest scores.

The results strengthen findings from earlier studies that suggest olfactory impairment begins between two and seven years before diagnosis.

Why problems with smelling accompany Parkinson's is not completely understood; however, nerve loss and the formation of Lewy bodies -- abnormal clumps of proteins inside nerve cells that are thought to be a marker of the disease -- are known to take place in the olfactory structures of patients with the disease.

The study authors noted that one previous study involving brain dissection of deceased patients with neurological disease found that olfactory structures are the earliest brain regions affected by Lewy degeneration, which supports the idea that an impaired sense of smell could be one of the earliest signs of Parkinson's disease.

An impaired sense of smell could also be caused by impaired sniffing, which may be another motor symptom of Parkinson's.

Olfactory testing, along with screening for other potential early indicators of Parkinson's disease such as constipation or sleep disturbances, could provide a simple and relatively economic means of identifying individuals at high risk who could participate in trials of medications designed to prevent or slow disease progression, the authors concluded in a prepared statement.

More information

The National Institute of Neurological Disorders and Stroke has more about Parkinson's disease.

-- Kevin McKeever

SOURCE: American Neurological Association, news release, March 20, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Antisense therapeutics scientist out to pull more big deals
2. Impaired sense of smell may be early indicator of Parkinsons disease
3. New Scenic Relaxation Videos Help Reduce Stress, Promote Sense of Calm and Tranquility
4. Sense of personal control influences Latinas decisions about sexual debut
5. URAC Names Sensei for Weight Loss as a Finalist in First-Ever Best Practices in Consumer Empowerment and Protection Awards
6. Isis and Excaliard Collaborate to Develop Antisense Drugs for Local Treatment of Fibrotic Diseases
7. How do we make sense of what we see?
8. Bayer Awards Making Science Make Sense Grant to Girl Scouts
9. Redsense Medical Receives FDA Approval for Blood Loss Detection Device
10. Ex-Head of Menarini Diabetes Unit Launches WaveSense Europe
11. Majority of House of Representatives Support Common-Sense Fix to Medicare Part D Prescription Drug Plan
Post Your Comments:
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World ... with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented ... in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor the ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this award, ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm ... sciences executive with extensive sequencing and genomics experience, as Vice President of North American ... Hill will be responsible for leading the sales team in the commercialization of the ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 The Academy ... of recommendations that would allow biopharmaceutical companies ... with entities that make formulary and coverage decisions, a ... "value" of new medicines. The recommendations address ... not appear on the drug label, a prohibition that ...
(Date:6/24/2016)... -- Research and Markets has announced the addition ... report to their offering. ... The World Market for Companion Diagnostics covers the world ... in the report includes the following: , ... by Region (N. America, EU, ROW), 2015-2020 , World ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
Breaking Medicine Technology: