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Poniard Pharmaceuticals Reports Second Quarter 2008 Financial Results and Corporate Update
Date:7/31/2008

as 27 weeks for platinum-refractory and -resistant SCLC patients, a population for which there are very few treatment options.

-- Colorectal Cancer: Completed enrollment in our randomized, controlled Phase 2 trial in patients with CRC and presented positive preliminary results from this study at ASCO. Preliminary data suggested that picoplatin given once every four weeks in combination with 5-fluorouracil and leucovorin in the FOLPI regimen may have similar anti-tumor activity to oxaliplatin in combination with 5-fluorouracil and leucovorin in the FOLFOX regimen, which is the current standard of care in the first-line treatment of CRC.

We also presented expanded and updated results from our Phase 1 dose-escalation study in patients with CRC treated with FOLPI treatment administered every two or four weeks. None of the patients treated with picoplatin at doses of up to a cumulative dose of 1,350 mg/m2 exhibited severe neuropathy (Grade 3 or 4) in 62 evaluable patients. Current use of FOLFOX in CRC patients is associated with substantial neurotoxicity related to increasing cumulative doses of oxaliplatin at greater than 800 mg/m2. In addition, nephrotoxicities and ototoxicities were rare and mild with the FOLPI regimen.

-- Prostate Cancer: Presented preliminary safety and efficacy at ASCO data from our ongoing Phase 2 clinical trial of picoplatin in combination with docetaxel and prednisone, the standard of care for the first-line treatment of HRPC. Results to date demonstrated that picoplatin can be safely administered at full-dose docetaxel. Prostate specific antigen levels, or PSA normalized in 23 percent of patients. The data also demonstrated that reductions in PSA of at least 50 percent were achieved in 69 percent of evaluable patients. This compares favorably to published docetaxel treatment PSA response rates of approximately 45 percent.

-- Ovarian and Other Advanced Solid Tumors: Announced positive safety and efficacy data at ASCO
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SOURCE Poniard Pharmaceuticals, Inc.
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