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Ponatinib acts against the most resistant types of chronic myeloid leukemia
Date:11/28/2012

agnosis.
  • More than 60 percent of the 15 patients in chronic phase CML with non-T315I mutations and 13 with no detectable mutations achieved a major cytogenetic response.
  • All 12 of the chronic phase CML patients with T315I remained on the study at the time of analysis.
  • Of 22 patients with advanced CML (accelerated or blast stages) eight had a major hematological response, seven a major cytogenetic response and two a major molecular response.
  • Seven patients had advanced CML and the T315I mutation. Two achieved major hematologic response, two major cytogenetic responses and two major molecular responses.

    The dose escalation trial started at a daily oral dose of ponatinib of 2 mg ranging up to 60 mg. The investigators settled on a 45mg dose.

    The most common non-hematologic side effects were skin disorders, fatigue and nausea at the lower grade 1 or 2 levels. Pancreatitis occurred in 11 patients and was a serious adverse event in eight. Nine of the 11 experienced one episode of pancreatitis, only two discontinued treatment.

    Twelve patients with acute myeloid leukemia also participated in the trial. A separate paper will address those results.


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  • Contact: Scott Merville
    smerville@mdanderson.org
    713-792-0661
    University of Texas M. D. Anderson Cancer Center
    Source:Eurekalert

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