Navigation Links
Ponatinib acts against the most resistant types of chronic myeloid leukemia
Date:11/28/2012

BCR-ABL, which occurs when two chromosomes swap portions of their DNA from the BCR and ABL genes during cell division. This abnormality is called the Philadelphia chromosome and the resultant BCR-ABL fusion protein drives the overproduction of white blood cells that characterizes CML. BCR-ABL is a tyrosine kinase, a type of protein that acts as an on-off switch by attaching a phosphate group to other proteins.

Discovery of the drug imatinib (Gleevec) revolutionized treatment of CML. Now approximately 90 percent of patients survive for at least five years, up from about 50 percent before imatinib. Two second-generation drugs, nilotinib (Tasigna) and dasatinib (Sprycel) are more potent than imatinib. Each can be used in frontline therapy.

"Imatinib is a terrific drug, however 30-40 percent of CML patients become resistant to it," Cortes said. "Nilotinib and dasatinib work for 40-50 percent of these patients."

Preclinical experiments indicated ponatinib acts against BCR-ABL and all known mutant forms of the protein.

Ponatinib active against known mutations and no mutations

The phase I trial enrolled 81 patients with blood cancers at five centers, 60 with CML and five with Philadelphia Chromosome-positive ALL. The patients had relapsed or resistant disease and 91 percent had been treated with at least two of the approved drugs. Median follow-up was 56 weeks.

  • Among 43 chronic phase CML patients, 42 had complete hematological response, 31 (72 percent) had a major cytogenetic response, 27 (63 percent) had a complete cytogenetic response (no CML cells in the bone marrow) and 19 (44 percent) achieved major molecular responses.
  • Duration of response for chronic phase patients with major cytogenetic response ranged from 8 to 117 weeks, with median duration yet to be reached.
  • Patients treated within 0 to 5 years of diagnosis had better response rates than those treated with ponatinib 5 to 24 years after di
    '/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Doubling down against diabetes
2. Pictures effective in warning against cigarette smoking
3. New bacteria to fight against intestinal inflammation
4. Fish, But Not Fish Oil Supplements, May Shield Against Stroke
5. High levels of vitamin D in plasma protects against bladder cancer
6. Feinstein Institute researchers discover that bean used in Chinese food could protect against sepsis
7. New Pill Shows Promise Against Relapsing Multiple Sclerosis
8. Doctors Biased Against Drug Company Research, Study Finds
9. Drug Shows Promise Against Fragile X Syndrome, Possibly Autism
10. FDA Warns Against Use of Diarrhea Drug From El Salvador
11. Vall d’Hebron, VHIO and SOLTI head up an international dream team against breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... On Saturday, October 25, 2014, the Brownsville Community Health ... fitness fair ¡Vive tu vida! Get Up! Get Moving!®. The ... better health and wellness for people of all ages and ... the public, will be held at Dean Porter Park, 501 ... pm. , “¡Vive tu Vida! Get Up! Get Moving!® ...
(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. 21, ... Ebola cases in Dallas. But, mental health specialists say overblown ... President Barack Obama on Friday appointed an Ebola "czar" to ... two Dallas nurses who cared for a Liberian man who ... But the U.S. cases are miniscule in the context ...
(Date:10/22/2014)... 22, 2014 With the Affordable Care Act ... by the American Institutes for Research (AIR) finds that three ... use health insurance, but 42 percent say they are not ... before signing up for coverage. , The AIR survey found ... percent able to calculate correctly how much they owe for ...
(Date:10/22/2014)... Although there are only 24 hours in a day, that doesn’t ... finding time within their busy schedules for exercise and fitness. Fortunately, ... to get in shape. Here are five ways you can reach ... Change Up Your Commute , Consider riding a bike or taking ... your daily routine. If you must use your car to get ...
(Date:10/22/2014)... Maureen Salamon HealthDay Reporter ... undergoing in vitro fertilization (IVF) are only about half as ... assisted reproduction technique, new research indicates, and the racial disparity ... study, about 31 percent of white patients became pregnant after ... Analyzing more than 4,000 IVF cycles over two years to ...
Breaking Medicine News(10 mins):Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 2Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 3Health News:Brownsville Community Health Center Presents Fourth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 4Health News:Ebola Anxiety: A Bigger Threat Now Than the Virus Itself 2Health News:Ebola Anxiety: A Bigger Threat Now Than the Virus Itself 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 4Health News:HealthGuideMD Presents Ways to Improve Your Exercise and Fitness 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 2Health News:Black Women Fare Worse With Fertility Treatments, Study Says 3
... recommended that infant be put to sleep in separate beds ... The number of infant deaths as a consequence of parents ... considerably increased over the recent years according to a report, ... weight infants, male infants and those that sleep on their ...
... melanoma among the Hispanic population of California. In a new ... a peer-reviewed journal of the American Cancer Society, the researchers ... is of the thicker variety, meaning that it has relatively ... is by far a minor percentage of all skin cancers, ...
... baby from Pakistan was given a new lease of life ... Sri M.G. Ramachandra Medical College and Hospital.// Fifteen-month-old Maxwell Qayyum ... was operated upon in Chennai, and he is reported to ... team of pediatricians conducted the surgery. ,The ...
... with pulmonary embolism can be identified through risk factors like blood ... of death due to this factor // can be treated ... Medicine. The condition is due to an abrupt blockage of an ... dislodged. In the US, this is a major health hazard. This ...
... his team from Johns Hopkins University School of Medicine ... of Medicine // that Antiretroviral combination drug of Tenofovir, ... controlling HIV load compared to most widely used drug ... trial called ‘study 934’ was conducted in 517 HIV ...
... maternity care is expected, with a London- based NHS hospital ... pregnant women who pay ?4,000. The novel scheme would be ... ,The provision of such a cost-effective one-to-one service during ... impossible to reach due to high demand. However, it continues ...
Cached Medicine News:Health News:Invasive Skin Cancer On The Rise in Hispanics 2Health News:London Hospital Provides Specialized Care For Pregnant Women 2
(Date:10/22/2014)...  With a vision to ensure safety and ... Pharmaceutical and Biotech manufacturer selects and implements the ... to protect their animal health brand.  ... Photo - http://photos.prnewswire.com/prnh/20141021/153439 ... by the Xyntek and Antares solution is an ...
(Date:10/22/2014)... DIEGO , Oct. 21, 2014   ... today the latest genomics research centers to purchase ... Salk Institute, the National Cancer Institute (NCI), NIH ... Sequencing Center). Before Irys, obtaining a comprehensive view ... next generation sequencing (NGS) does not deliver the ...
(Date:10/22/2014)... 21, 2014 Abaxis, Inc. (NasdaqGS: ... analysis systems, today reported financial results for the second ... quarter overview: , Revenues of $53.9 million, up ... EPS of $0.24, up 33% over last year,s comparable ... from Abaxis Veterinary Reference Laboratories (AVRL) of $3.5 million, ...
Breaking Medicine Technology:Xyntek and Antares Serialization Solution Protects Pets Too! 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 3Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 2Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 3Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 4Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 5Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 6Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 7Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 8Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 9Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 10Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 11Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 12Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 13Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 14
... 27, 2011 Inovio Pharmaceuticals, Inc. (NYSE Amex: ... synthetic immunogens against cancers and infectious diseases, announced today ... Development Agreement (CRADA) with the United States Department of ... Animal Disease Center. This collaboration will evaluate the efficacy ...
... Co., Inc. (NYSE Amex: TPI ), a pharmaceutical ... branded generics and other pharmaceuticals, announced the financial results for ... year 2011 ending June 30 ... delivered $95.2 million, exceeding the guided $90.0 million revenue forecast ...
Cached Medicine Technology:Inovio Pharmaceuticals Enters Collaboration With U.S. Dept. of Homeland Security to Assess Foot & Mouth Disease Synthetic Vaccines' Potential to Help Ensure Nation's Food Supply Safety 2Inovio Pharmaceuticals Enters Collaboration With U.S. Dept. of Homeland Security to Assess Foot & Mouth Disease Synthetic Vaccines' Potential to Help Ensure Nation's Food Supply Safety 3Inovio Pharmaceuticals Enters Collaboration With U.S. Dept. of Homeland Security to Assess Foot & Mouth Disease Synthetic Vaccines' Potential to Help Ensure Nation's Food Supply Safety 4TPI Reports Fiscal Year 2011 Financial Results 2TPI Reports Fiscal Year 2011 Financial Results 3TPI Reports Fiscal Year 2011 Financial Results 4TPI Reports Fiscal Year 2011 Financial Results 5TPI Reports Fiscal Year 2011 Financial Results 6TPI Reports Fiscal Year 2011 Financial Results 7TPI Reports Fiscal Year 2011 Financial Results 8TPI Reports Fiscal Year 2011 Financial Results 9TPI Reports Fiscal Year 2011 Financial Results 10TPI Reports Fiscal Year 2011 Financial Results 11
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: