Navigation Links
Polyphenols in red wine and green tea halt prostate cancer growth
Date:6/9/2010

In what could lead to a major advance in the treatment of prostate cancer, scientists now know exactly why polyphenols in red wine and green tea inhibit cancer growth. This new discovery, published online in The FASEB Journal (http://www.fasebj.org), explains how antioxidants in red wine and green tea produce a combined effect to disrupt an important cell signaling pathway necessary for prostate cancer growth. This finding is important because it may lead to the development of drugs that could stop or slow cancer progression, or improve current treatments.

"Not only does SphK1/S1P signaling pathway play a role in prostate cancer, but it also plays a role in other cancers, such as colon cancer, breast cancer, and gastric cancers," said Gerald Weissmann, MD, editor-in-chief of The FASEB Journal. "Even if future studies show that drinking red wine and green tea isn't as effective in humans as we hope, knowing that the compounds in those drinks disrupts this pathway is an important step toward developing drugs that hit the same target."

Scientists conducted in vitro experiments which showed that the inhibition of the sphingosine kinase-1/sphingosine 1-phosphate (SphK1/S1P) pathway was essential for green tea and wine polyphenols to kill prostate cancer cells. Next, mice genetically altered to develop a human prostate cancer tumor were either treated or not treated with green tea and wine polyphenols. The treated mice showed reduced tumor growth as a result of the inhibited SphK1/S1P pathway. To mimic the preventive effects of polyphenols, another experiment used three groups of mice given drinking water, drinking water with a green tea compound known as EGCg, or drinking water with a different green tea compound, polyphenon E. Human prostate cancer cells were implanted in the mice and results showed a dramatic decrease in tumor size in the mice drinking the EGCg or polyphenon E mixtures.

"The profound impact that the antioxidants in red wine and green tea have on our bodies is more than anyone would have dreamt just 25 years ago," Weissmann added. "As long as they are taken in moderation, all signs show that red wine and green tea may be ranked among the most potent 'health foods' we know."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Pennsylvania EPA Awards Abington Memorial Hospital Funding for Green Projects
2. Hard Green Truths - Keynotes Suggest New Value Propositions for River Park Leaders
3. Waylon Lewis of elephantjournal.com: iPad: Green?; Yoga Star Hemalayaa Behl
4. Inspired Solar Technologies (IST) Names James E. Green as CEO
5. Clean and green: Supermarket shelves awash in eco-friendly laundry detergents
6. Green Tea May Help Treat Uterine Fibroids
7. Dont forget to eat your greens
8. Greenfaith Ministry Calls on Churches & Doctors, to Address all Cannabis Issues and Regulation
9. Researchers at Meharry Medical College Find Green Tea Extract Showing Promise for Treatment of Uterine Fibroids
10. Guardian Launches Campaign to Bolster Use of Web Capabilities to Advance Green Initiatives and Enhance Service
11. Northeast Ohio Hospital System Announces New “Green” Initiative
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... January 17, 2017 , ... The Sharie Withers ... has announced the latest beneficiary of their thriving community involvement program. The current ... to fulfilling the dreams of terminally ill patients. Donations to this worthy cause ...
(Date:1/17/2017)... ... January 17, 2017 , ... Many people make New Year’s resolutions or renew their ... is making it easier for people who want to kick off 2017 with better ... existing patients. , These special offers include: , , A ...
(Date:1/17/2017)... ... 17, 2017 , ... Twelve (12) years ago the Yogi ... program forged a relationship built upon the foundation of sports safety. Recently, ... both student members and certified members of the Athletic Trainers’ Society of New ...
(Date:1/16/2017)... ... January 17, 2017 , ... Recently, patients and staff ... Michigan, joined other volunteers and organizations in support of the annual Binder Park Zoo ... families dressed up in colorful costumes of all designs coming out to enjoy games, ...
(Date:1/16/2017)... ... 2017 , ... Gym Source, America’s leading retailer of premium residential and commercial ... Jersey. , “We are elated to be opening this new showroom,” explains Tom Richard, ... give clients a seamless and motivating shopping experience.” , Every fitness journey is unique, ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... Interpace Diagnostics Group, Inc., (NASDAQ: IDXG ... tests and pathology services for evaluating risks of cancer, ... January 13, 2017 from the NASDAQ Listing Qualifications notifying ... requirement of the NASDAQ Stock Market to maintain a ... The letter noted that for the last 10 ...
(Date:1/17/2017)... Jan. 17, 2017 Tempus, a technology ... and University Hospitals Seidman Cancer Center have joined ... genomic data, advanced molecular analysis and clinical decision ... and healthcare providers. As part ... and transcriptomic sequencing and analysis for ovarian and ...
(Date:1/17/2017)... , Jan. 17, 2017  CSSi, the global ... the clinical research industry, will exhibit at the 8 ... Executives (SCOPE 2017), taking place from Tuesday, January 24 ... Miami in Miami, FL. ... proprietary technology platform, SmartStudy™ EMR, which provides a revolutionary ...
Breaking Medicine Technology: