Navigation Links
Polyphenols in red wine and green tea halt prostate cancer growth
Date:6/9/2010

In what could lead to a major advance in the treatment of prostate cancer, scientists now know exactly why polyphenols in red wine and green tea inhibit cancer growth. This new discovery, published online in The FASEB Journal (http://www.fasebj.org), explains how antioxidants in red wine and green tea produce a combined effect to disrupt an important cell signaling pathway necessary for prostate cancer growth. This finding is important because it may lead to the development of drugs that could stop or slow cancer progression, or improve current treatments.

"Not only does SphK1/S1P signaling pathway play a role in prostate cancer, but it also plays a role in other cancers, such as colon cancer, breast cancer, and gastric cancers," said Gerald Weissmann, MD, editor-in-chief of The FASEB Journal. "Even if future studies show that drinking red wine and green tea isn't as effective in humans as we hope, knowing that the compounds in those drinks disrupts this pathway is an important step toward developing drugs that hit the same target."

Scientists conducted in vitro experiments which showed that the inhibition of the sphingosine kinase-1/sphingosine 1-phosphate (SphK1/S1P) pathway was essential for green tea and wine polyphenols to kill prostate cancer cells. Next, mice genetically altered to develop a human prostate cancer tumor were either treated or not treated with green tea and wine polyphenols. The treated mice showed reduced tumor growth as a result of the inhibited SphK1/S1P pathway. To mimic the preventive effects of polyphenols, another experiment used three groups of mice given drinking water, drinking water with a green tea compound known as EGCg, or drinking water with a different green tea compound, polyphenon E. Human prostate cancer cells were implanted in the mice and results showed a dramatic decrease in tumor size in the mice drinking the EGCg or polyphenon E mixtures.

"The profound impact that the antioxidants in red wine and green tea have on our bodies is more than anyone would have dreamt just 25 years ago," Weissmann added. "As long as they are taken in moderation, all signs show that red wine and green tea may be ranked among the most potent 'health foods' we know."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Pennsylvania EPA Awards Abington Memorial Hospital Funding for Green Projects
2. Hard Green Truths - Keynotes Suggest New Value Propositions for River Park Leaders
3. Waylon Lewis of elephantjournal.com: iPad: Green?; Yoga Star Hemalayaa Behl
4. Inspired Solar Technologies (IST) Names James E. Green as CEO
5. Clean and green: Supermarket shelves awash in eco-friendly laundry detergents
6. Green Tea May Help Treat Uterine Fibroids
7. Dont forget to eat your greens
8. Greenfaith Ministry Calls on Churches & Doctors, to Address all Cannabis Issues and Regulation
9. Researchers at Meharry Medical College Find Green Tea Extract Showing Promise for Treatment of Uterine Fibroids
10. Guardian Launches Campaign to Bolster Use of Web Capabilities to Advance Green Initiatives and Enhance Service
11. Northeast Ohio Hospital System Announces New “Green” Initiative
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... , ... May 31, 2016 , ... TeaZa® Energy, ... herbal energy pouches, on World No Tobacco Day . The new flavor—Tropical ... locations later on this summer. , The new flavor is best described as ...
(Date:5/31/2016)... ... May 31, 2016 , ... Dr. Charles A. Ditta attained ... New Jersey in the class of 1986, where he graduated in the top ten ... current location in Livingston since 1989. He has been a member in good standing ...
(Date:5/31/2016)... ... May 31, 2016 , ... CURE ... patients with cancer, has added Cancer and Careers to its ... timely content on continuing successful careers while fighting cancer. , As partners, both ...
(Date:5/30/2016)... Viejo, California (PRWEB) , ... May 30, 2016 ... ... are easy to use inside of FCPX," said Christina Austin - CEO of ... created exclusively for use within Final Cut Pro X. Choose from abstract transitions ...
(Date:5/30/2016)... Lewisville, Texas (PRWEB) , ... May 30, 2016 , ... ... at 7 am in Plano, located at 3960 Legacy Drive, Plano, TX and is ... the Plano Chamber of Commerce followed by a medical open house. The Jasper High ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... 2016 , Isansys  Lifecare, a new ... Status Engine wireless patient monitoring platform, as it ships more ... Germany , Scotland and ... generation system, launched earlier this year, is now being used ... , This new technology significantly enhances the user ...
(Date:5/30/2016)... 30, 2016 Transparency Market Research ... Visualization Systems Market - Global Industry Analysis, Size, Share, ... the report, the global advanced (3D/4D) visualization systems market ... is anticipated to expand at a CAGR of 6.4% ... in 2024. Advanced (3D/4D) visualization systems have ...
(Date:5/30/2016)... , May 30, 2016 ... to reach USD 7.3 billion by 2024, according ... Inc. The increasing natality rate, the growing malnutrition ... as cancer and gastro-intestinal tract diseases are expected ...      (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) ...
Breaking Medicine Technology: