Polyanalgesic Consensus Panel's New Treatment Guidelines Via Intraspinal Infusion for Severe Ch... (in 2004 and is a non-narcotic synthetic ...)

Polyanalgesic Consensus Panel's New Treatment Guidelines Via Intraspinal Infusion for Severe Chronic Pain

Date:10/31/2007

in 2004 and is a non-narcotic synthetic based conopeptide found in the Conus magus marine snail. It is an important addition to the list of options physicians have to treat severe chronic pain. Unlike intraspinal opioids, PRIALT is not known to be associated with granuloma formation, which means physicians and patients alike don't have to stop therapy and evaluate the need for catheter removal and replacement, according to Dr. Deer.

"The issue of chronic pain impacts the lives of one in four Americans," said Will Rowe, executive director of the American Pain Foundation. "People with chronic pain have different responses to the same medicines. What works for one, might not work for another. We support the development and availability of treatment options for people affected by pain and are very pleased that the Polyanalgesic Panel is elevating ziconotide to a first-line intraspinal infusion pain treatment option for patients and physicians to consider." [Please see important safety information for PRIALT].

The panel also recommends a slow dosage titration of PRIALT from 0.5 to 2.4 micrograms per day starting dosage range, with a maximum of 19.2 micrograms per day, to help reduce the risk of side effects.

According to Dr. Deer, the rapidly changing landscape of intraspinal drug delivery treatments necessitates periodic update of the guidelines so physicians can make informed treatment decisions that will most benefit their patients.

The original guidelines were published in 2000 in the peer reviewed Journal of Pain and Symptom Management. The guidelines were updated in 2003 and the panel's recommendations published the following year in the same journal. In previous years, the panel determined that preclinical and clinical trial data should include evidence of safety, efficacy, stability and compatibility with drug delivery systems, and, in the case of drug combinations, drug-drug stability.

Please see PRIALT full prescribing information
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