Navigation Links
PolyU Scientists Help Identify Genes Causing Myopia
Date:6/3/2013

(PRWEB) June 04, 2013

Two researchers from The Hong Kong Polytechnic University (PolyU) are taking an active role in a global study which has unlocked the genetic origin of myopia. Through their collaboration with the Consortium for Refractive Error and Myopia (CREAM), 24 genes leading to short-sightedness have been identified, thus paving the way for further research on the prevention and control of myopia.

This largest international genome-wide study was based on the meta-analysis of 45,758 subjects, including 37,382 individuals of European ancestry and 8,376 from Asian countries, with the concerted efforts of 64 universities and research institutes in 13 countries. On Hong Kong side, joining the CREAM are Dr Jeremy Guggenheim, Associate Professor at PolyU's School of Optometry, and Professor Yip Shea-ping, Associate Head (Research) of PolyU's Department of Health Technology and Informatics. Both of them are also members of PolyU's Centre for Myopia Research.

PolyU researchers also noted that over the past 30 years, the number of Hong Kong children developing myopia has risen alarmingly. This year, about 80 per cent will have the condition by the time they leave school. Similarly high rates of myopia are seen in cities on the Chinese mainland, Japan, Taiwan and Singapore.

People with myopia have longer than normal eyeballs, which result in their focusing of images in front of their retinas instead of on them. It is estimated that up to 80% of Asians and 30% of Caucasians are myopic, and high myopia can lead to blindness. Environmental risk factors may have played a large part in increasing the prevalence in Asia over the past half-century, such as children spending less time doing outdoor activities due to dense urbanisation and parental pressure to do well academically.

"It is important to identify genetic factors because they could open the door to developing drugs that can hinder myopia. We now have a long list of genes to examine in details, to find out how they put children at risk," explained PolyU optometry expert Dr Guggenheim.

Instead of recruiting subjects or families with high degrees of myopia, the meta-analyses examined data of unselected subjects from health studies, which would be more representative of people around the world.

"We have found 16 new loci of genes for refractive error in people of European descent, of which 8 loci are shared with people of Chinese, Indian or Malay descent. In addition, we have confirmed a further 8 associated loci," said Professor Yip.

The consortium also identified new candidate genes involved in possible mechanisms linked to eye growth and myopia. Some of the genes may be involved in the growth of the sclera, the white outer layer of the eyeball, while other genes may be involved in determining the strength of chemical signals generated by the retina when viewing images, which may influence the onset and progression of myopia.

According to this study, people with all the genetic risk factors have a tenfold-increased risk of developing myopia.

The findings have recently been published in Nature Genetics.

Read the full story at http://www.prweb.com/releases/2013/6/prweb10794201.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Renowned Master of Wine Jeannie Cho Lee Appointed Professor of Practice (Wine) by PolyU
2. PolyU Researchers Develop Novel Treatment for People with Hemiplegic Arms
3. Limiting polyunsaturated fatty acid levels in pregnancy may influence body fat of children
4. New Colored Polyurethane Medical Tape - Now Available Through Strouse
5. PolyU Introduces "Mathematics Challenge for Young Australians" for Gifted Students
6. PolyU Wins Top Prizes in Geneva’s Invention Expo
7. PolyU introduces International Design and Business Management Master Programme to Develop "T-Shaped" Professionals
8. PolyU and University of Chinese Academy of Sciences Launch Joint PhD Supervision Scheme for Management Students
9. PolyU Students Show Prowess in UAV Design Competition
10. PolyU Researchers Develop Novel Brain Training Device to Reconnect the Brain and Paralyzed Limb After Stroke
11. PolyU and Sichuan U Jointly Set Up China's First Institute for Disaster Management and Reconstruction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... Mirixa Corporation ... adherence, and other pharmacist-delivered patient care services, has announced the promotions of Karen ... to vice president of sales. , Litsinger joined Mirixa in 2008 after ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... David ... with global law firm Greenberg Traurig, LLP, will speak at DeviceTalks West, Dec. 12, ... of the DeviceTalks series, and attorneys from the firm’s global Life Sciences & Medical ...
(Date:12/8/2016)... ... December 08, 2016 , ... Launching ... innovative Unified Instance Manager architecture, meeting the needs of multichannel growth and ... the unattended auto-dialing system without agents, Presence Robodialer, provides greater operational capacity, ...
(Date:12/8/2016)... ... December 08, 2016 , ... STAT courier is pleased to announce that ... for Texas, they are expanding their presence in Dallas. One of the most exciting ... bring new jobs to the Dallas and Forth Worth market. STAT takes pride in ...
(Date:12/8/2016)... ... December 08, 2016 , ... Healthcare is ... Dr. Botelho advocates for the mass media launching of story movements to highlight ... to share their unfortunate experiences; such a movement can generate the network power ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)...  Valeant Pharmaceuticals International, Inc. (NYSE: ... positive results from a Phase 3, multicenter double-blind, ... and efficacy of IDP-118 (halobetasol propionate and tazarotene) ... Within the Phase 3 study of ... IDP-118 showed statistical significance to vehicle with a ...
(Date:12/8/2016)... Texas , Dec. 8, 2016 ... program that brings leading-edge laboratory services and management ... United States , allowing more doctors and ... health care management solutions. Logo - ... Hospital systems, under pressure to contain ...
(Date:12/8/2016)... Information products and services provider Elsevier has ... the world,s largest abstract and citation database of peer-reviewed literature, providing ... over 5,000 publishers. The new set of metrics will improve decisions ... to adjust a journal,s editorial strategy. ... , , CiteScore metrics ...
Breaking Medicine Technology: