Navigation Links
Polluted air leads to disease by promoting widespread inflammation
Date:4/14/2011

COLUMBUS, Ohio Chronic inhalation of polluted air appears to activate a protein that triggers the release of white blood cells, setting off events that lead to widespread inflammation, according to new research in an animal model.

This finding narrows the gap in researchers' understanding of how prolonged exposure to pollution can increase the risk for cardiovascular problems and other diseases.

The research group, led by Ohio State University scientists, has described studies in mice suggesting that chronic exposure to very fine particulate matter triggers events that allow white blood cells to escape from bone marrow and work their way into the bloodstream. Their presence in and around blood vessels alters the integrity of vessel walls and they also collect in fat tissue, where they release chemicals that cause inflammation.

The cellular activity resembles an immune response that has spiraled out of control. A normal immune response to a pathogen or other foreign body requires some inflammation, but when inflammation is excessive and has no protective or healing role, the condition can lead to an increased risk for cardiovascular diseases, diabetes and obesity, as well as other disorders.

Though many questions about the beginning of this process remain unanswered, the scientists predict that the damage may originate in fluid that lines the lung. Tiny molecules in this fluid change structure after being exposed to polluted air, and that change appears to set off this cascade of damaging white blood cell behavior by activating a receptor called "toll-like receptor 4."

The job of toll-like receptor 4, or TLR4, is to recognize specific characteristics of pathogens and then send out signals to activate other players in the immune system. Mice that lack this molecule don't produce as much inflammation after exposure to pollution as do normal mice, suggesting that TLR4 has a prominent role in the body's response to chro
'/>"/>

Contact: Sanjay Rajagopalan
sanjay.rajagopalan@osumc.edu
614-247-7760
Ohio State University
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Polluted air increases obesity risk in young animals
2. Polluted Air Another Danger to U.S. Troops in Iraq
3. Learning Lab of Brentwood Leads Free ADHD Seminar
4. Human Dental Technology Leads to Breakthroughs for Pet Dental Health at Sergeants Pet Care Products, Inc.
5. TechCFO Enters Mid-Atlantic Market; Rick Rolandi Leads DC Metro Office
6. Home Health Agency Owner Pleads Guilty in Connection with Detroit Fraud Scheme
7. New DNA technique leads to a breakthrough in child cancer research
8. AGA leads the way in GI innovation
9. Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
10. KV Pharmaceutical Subsidiary Pleads Guilty to Two Felonies Regarding Oversized Drugs
11. China's Forbidden City Leads Landmark Climate Action for Earth Hour
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... This is a professional and ... Cholesterol industry in Global and China. The report ... definitions, applications and industry chain structure. Global market ... with a focus on history, developments, trends and ... the international and Chinese situation is also offered. ...
(Date:7/11/2014)... Growing old was thought of as a fate that ... it was shown that many of the “myths” people associate ... turns out, the elderly can still live quite as fruitfully as ... the time in the world, older people also need to live ... in the twilight of their lives. This is why Guy Coalter, ...
(Date:7/11/2014)... July 11, 2014 Hands-On ... this August in New York. This ... , -Myofascial Trigger Point Therapy, -Strain ... & Thrust Manipulation, -Neuroobilization & Neurodynamics, -Proprioceptive ... to a single, isolated manual therapy school ...
(Date:7/11/2014)... People with physical disabilities and military ... the increasing numbers of people partnered with assistance dogs. ... productive lives. , But are these service dog ... dog an impediment to employment? , In honor ... - 9, 2014, West Virginia University associate professor and ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Even the hot ... Godley Elementary School . The school had ... playground equipment from APCPLAY, but recently asked for ... exposure. , Godley Elementary School chose a Rectangular ... and shelter for children on their playground. The shade ...
Breaking Medicine News(10 mins):Health News:Cholesterol Industry 2014 Development Trends in Global & China Regions in a New Research Study Available at DeepResearchReports.com 2Health News:Cholesterol Industry 2014 Development Trends in Global & China Regions in a New Research Study Available at DeepResearchReports.com 3Health News:It’s All Free For Seniors Review, How To Take Advantage of What Life Has to Offer In Old Age – Vinamy.com 2Health News:It’s All Free For Seniors Review, How To Take Advantage of What Life Has to Offer In Old Age – Vinamy.com 3Health News:Hands-On Seminars, the Leader in Manual Therapy Continuing Education, Announces Series of Comprehensive Hands-On Training Courses 2Health News:Will Your Next Employee or Co-Worker Be a Dog? 2Health News:Will Your Next Employee or Co-Worker Be a Dog? 3Health News:Will Your Next Employee or Co-Worker Be a Dog? 4Health News:Cool Fun Under the Texas Sun: Godley Elementary School Purchases Shade Structure from APCPLAY© 2
... in the human diet mean people today are more at ... said.Researchers at the University of Newcastle believe that changes to ... off its anti-cancer agents. ,The researchers are working ... in fighting stomach cancer. They are carrying out two trials ...
... an amino-acid taste receptor.Dr Charles S. Zuker, from ... of California, San Diego, reports his team's findings ... tastes — bitter, salty, sour, sweet, and umami. ... (MSG).Receptors that responded to umami have been discovered ...
... are associated with permutation in brain structure that appear ... conducted by researchers at the University of Iowa.// ... and 54 male control subjects, the researchers used magnetic ... They found that the volume of the anterior portion ...
... shun most of the dangers of developing lung cancer. There are ... are former smokers compared with those who continue to smoke.// Over ... lung cancer in the world. ,One of the authors ... study in 1950 established the smoking and lung cancer link. A ...
... pollutant emitted by power plants and vehicles raises the ... of dying from lung cancer or heart disease//, and ... authors contend that simply living in a major urban ... its way into your lungs when you breathe, increasing ...
... exercise cut the risk of diabetes by over half. ... be at increased risk of developing diabetes.// Given that ... very useful if there was some way of helping ... for the Diabetes Prevention Programme in the US have ...
Cached Medicine News:Health News:Comprehension of taste receptor, 2
(Date:1/15/2014)... YORK , January 15, 2014 ... Ltd., the exclusive worldwide distributor of highly sophisticated agro-breeding ... on January 7, 2014, the Company,s board of directors ... Weiner as its new member of the board. ...
(Date:1/15/2014)... , Jan. 15, 2014 MultiCell Technologies, Inc. (OTC ... U.S. provisional patent application concerning composition of matter, biological ... targeted tumor cell death.  This patent ... double stranded RNA molecules (VSRNAs) which interfere with the ...
(Date:1/15/2014)... YORK , Jan. 15, 2014 ... report is available in its catalogue: ... Forecast – Worldwide Analysis ... Market Analysis Insulin ...
Breaking Medicine Technology:BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17
... that a new market research report is available in ... http://www.reportlinker.com/p0488682/Cancer-Reports-Bundle.html The Cancer ... a 15% discount off the individual reports being purchased separately: ... Therapies. - Cancer Cell Therapy Markets. ...
... president John F. Kennedy designated the month of May as ... a long-standing tradition to pay tribute to older adults. At ... birthday, according to the Administration on Aging. In 2009, this ... shift and older adults rely on the support of their ...
Cached Medicine Technology:Reportlinker Adds Cancer Reports Bundle 2Reportlinker Adds Cancer Reports Bundle 3Reportlinker Adds Cancer Reports Bundle 4Reportlinker Adds Cancer Reports Bundle 5Reportlinker Adds Cancer Reports Bundle 6Reportlinker Adds Cancer Reports Bundle 7Reportlinker Adds Cancer Reports Bundle 8May is Older Americans Month 2
... is a comprehensive IT solution that ... admission to follow-up. This scalable solution ... diagnostic tools from syngo Dynamics with ... longitudinal clinical repository that becomes a ...
... introduces the AXIOM Artis dBC Magnetic ... magnetic navigation system equipped with digital ... which is uniquely capable of improving ... procedures to facilitate increased efficiency and ...
The AXIOM Artis TC is ideal for applications above and beyond standard cardioangiography, and features:, Single plane C-Arm, ceiling-mounted, Full-size CCD camera, ...
The ACUSON Sequoia C512 system elevates imaging and Doppler performance through new, high-density acoustic sampling, precise control of the transmitted acoustic waveform, and new transducer technolog...
Medicine Products: