Navigation Links
Polluted air leads to disease by promoting widespread inflammation
Date:4/14/2011

COLUMBUS, Ohio Chronic inhalation of polluted air appears to activate a protein that triggers the release of white blood cells, setting off events that lead to widespread inflammation, according to new research in an animal model.

This finding narrows the gap in researchers' understanding of how prolonged exposure to pollution can increase the risk for cardiovascular problems and other diseases.

The research group, led by Ohio State University scientists, has described studies in mice suggesting that chronic exposure to very fine particulate matter triggers events that allow white blood cells to escape from bone marrow and work their way into the bloodstream. Their presence in and around blood vessels alters the integrity of vessel walls and they also collect in fat tissue, where they release chemicals that cause inflammation.

The cellular activity resembles an immune response that has spiraled out of control. A normal immune response to a pathogen or other foreign body requires some inflammation, but when inflammation is excessive and has no protective or healing role, the condition can lead to an increased risk for cardiovascular diseases, diabetes and obesity, as well as other disorders.

Though many questions about the beginning of this process remain unanswered, the scientists predict that the damage may originate in fluid that lines the lung. Tiny molecules in this fluid change structure after being exposed to polluted air, and that change appears to set off this cascade of damaging white blood cell behavior by activating a receptor called "toll-like receptor 4."

The job of toll-like receptor 4, or TLR4, is to recognize specific characteristics of pathogens and then send out signals to activate other players in the immune system. Mice that lack this molecule don't produce as much inflammation after exposure to pollution as do normal mice, suggesting that TLR4 has a prominent role in the body's response to chro
'/>"/>

Contact: Sanjay Rajagopalan
sanjay.rajagopalan@osumc.edu
614-247-7760
Ohio State University
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Polluted air increases obesity risk in young animals
2. Polluted Air Another Danger to U.S. Troops in Iraq
3. Learning Lab of Brentwood Leads Free ADHD Seminar
4. Human Dental Technology Leads to Breakthroughs for Pet Dental Health at Sergeants Pet Care Products, Inc.
5. TechCFO Enters Mid-Atlantic Market; Rick Rolandi Leads DC Metro Office
6. Home Health Agency Owner Pleads Guilty in Connection with Detroit Fraud Scheme
7. New DNA technique leads to a breakthrough in child cancer research
8. AGA leads the way in GI innovation
9. Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
10. KV Pharmaceutical Subsidiary Pleads Guilty to Two Felonies Regarding Oversized Drugs
11. China's Forbidden City Leads Landmark Climate Action for Earth Hour
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... CA (PRWEB) October 25, 2014 More ... annual President’s Circle Reception on Monday at the home ... accomplishments and hear from guest speaker Dr. Winifred Lender ... worlds. , Dr. Lender, a Santa Barbara psychologist, author ... challenges and benefits of living in the digital age. ...
(Date:10/25/2014)... 2014 The Wehrman Collaborative, ... IT-accessibility for disabled users by disabled users, has ... to Mackin Educational Resources of Burnsville, Minnesota, for ... and to the Minnesota Alliance for Patient Safety ... Medicine" website. Both organizations have met ...
(Date:10/25/2014)... 2014 Homeowners that are wondering how ... need wonder no more. Clean Crawls gives 5 ... out for when it comes to insulation in their ... article released by Clean Crawls, can cause problems throughout ... insulation that has deteriorated, become damp, or been infested ...
(Date:10/25/2014)... (PRWEB) October 25, 2014 Limbkeepers® announced ... episode of Innovations with Ed Begley Jr, airing 1st ... TBA. , In this episode, Innovations will focus on ... to protect fragile, thinning skin on arms, hands, and ... learn about these versatile products, which help reduce injuries, ...
(Date:10/25/2014)... -- Not getting the right amount of sleep might ... suggests. Those who sleep less or more than ... be more prone to developing the chronic condition, which ... authors concluded that duration and quality of sleep are ... bowel diseases. "Both short and long durations of ...
Breaking Medicine News(10 mins):Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 2Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 3Health News:Finding Balance between the Real & Digital World Topic of Family Service Agency Reception 4Health News:IT-Accessibility Award Granted to Education and Health Care for Section 508/WCAG 2Health News:IT-Accessibility Award Granted to Education and Health Care for Section 508/WCAG 3Health News:5 Signs Indicating That Insulation Needs Replacing as Told By Clean Crawls in Recent Article 2Health News:Upcoming Episode of Innovations with Ed Begley, Jr. to Feature Limbkeepers® 2Health News:Sleep Duration Linked to Ulcerative Colitis Risk in Study 2
... married life beat stress better than those live single, says ... buster//. ,Popular perception is that single people have a ... a loving relationship makes it easier to cope with the ... Daily Mail. ,Psychologist Dr Roxane Gervais monitored the ...
... ribosome is the protein-producing nanomachine in cells that keeps ... of Maryland researchers// has provided a clue that could ... HIV AIDS and SARS. ,In the March ... Maryland biology professor Jonathan Dinman and research assistant professor ...
... at Weill Cornell Medical College could prove a potent weapon ... called SS31, is able to cross the blood-brain barrier and ... damage. ,"In our experiments, we found that exposing ... a much smaller area of brain tissue being affected," says ...
... news for working couple in India. A study in the US ... more tended// to become disruptive in class. The effect persisted through ... of the child’s sex or family income, and regardless of the ... $200 million project financed by the National Institute of Child Health ...
... has approved four new drugs manufactured by the Macleods of ... of the four would be used against some strains of ... these four medicines will reinforce efforts to scale up access ... a statement. ,The medicines are the first TB ...
... that some foods and supplements do have an important role ... ‘big C’. At the 233rd national meeting of the American ... papers on this topic will be presented. ,Selected ... for preventing cancer of the esophagus, colon — Using animal ...
Cached Medicine News:Health News:New Ribosome Finding Could Lead to Antiviral Therapies 2Health News:Antioxidant Molecule Could Help Minimize Stroke-Linked Brain Damage 2Health News:Poor Behavior Is Linked to Time in Day Care 2Health News:Indian Pharma Authorized to Market New Anti-TB Drugs 2Health News:Emboldened Warriors-Cancer Fighting Foods 2Health News:Emboldened Warriors-Cancer Fighting Foods 3
(Date:10/25/2014)... DUBLIN , Oct. 24, 2014 ... "Dental Equipment Market Current Trends, Opportunities - Global ... In this report, the global dental equipment ... geography. The dental systems and equipment market is expected ... equipment market during the forecast period (2014 to 2019). ...
(Date:10/25/2014)... , Oct. 24, 2014  America,s future engineers ... robotic competition at the  Medical Design and Manufacturing ... 29-30 th at the Minneapolis ... local student built robots from the "For Inspiration ... FIRST students and mentors will offer information to ...
(Date:10/25/2014)... , October 24, 2014 ... the addition of the "Global and Chinese ... their offering.      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... Report 2014 is a professional and in-depth study ... industry with a focus on the Chinese situation. ...
Breaking Medicine Technology:Dental Equipment Market Current Trends, Opportunities - Global Forecast to 2019 2Dental Equipment Market Current Trends, Opportunities - Global Forecast to 2019 3Local robotics teams compete - a "FIRST" at next week's MD&M Minneapolis- October 29-30th at the Minneapolis Convention Center 2Local robotics teams compete - a "FIRST" at next week's MD&M Minneapolis- October 29-30th at the Minneapolis Convention Center 3Global and Chinese Hemodialysis Concentrates Industry Report 2014 2Global and Chinese Hemodialysis Concentrates Industry Report 2014 3
... Quark siRNAs Examined Alone and in Combination ... Quark Pharmaceuticals, Inc., a,development-stage pharmaceutical company ... today announced that the,journal Cancer Research published ... target gene against non-small cell lung cancer ...
... Prophylaxis Treatment with Kogenate FS Reduces the,Risk of ... No Pre-Existing,Joint Damage, BERKELEY, Calif., Oct. 10 ... Food and Drug Administration (FDA) has,approved routine prophylaxis ... frequency of bleeding episodes and the risk of,joint ...
Cached Medicine Technology:Quark Pharmaceuticals Announces Publication of Study on Use of siRNA against Proprietary Target for Inhibiting Tumor Growth and Sensitization of Cancer Cells to Chemotherapy 2Quark Pharmaceuticals Announces Publication of Study on Use of siRNA against Proprietary Target for Inhibiting Tumor Growth and Sensitization of Cancer Cells to Chemotherapy 3Quark Pharmaceuticals Announces Publication of Study on Use of siRNA against Proprietary Target for Inhibiting Tumor Growth and Sensitization of Cancer Cells to Chemotherapy 4FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A 2FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A 3FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A 4FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A 5
Synchron CX3 Delta is a critical care clinical system, providing unparalleled testing speed for the most frequently ordered chemistries-Glucose, BUN, Creatinine, Sodium, Potassium Chloride, CO2 Calci...
Iron (Total/Ferene). Storage temp: 15 - 30 C. Linearity: 0 - 500 ug/dl. Expected values: from males 60 - 160 ug/dl, from females 43 - 140 ug/dl. Available with Calibrator and Number of test are 120....
For the quantitative determination of iron, total iron-binding capacity in human serum....
HDL Cholesterol, liquid....
Medicine Products: