Navigation Links
Polluted air leads to disease by promoting widespread inflammation
Date:4/14/2011

COLUMBUS, Ohio Chronic inhalation of polluted air appears to activate a protein that triggers the release of white blood cells, setting off events that lead to widespread inflammation, according to new research in an animal model.

This finding narrows the gap in researchers' understanding of how prolonged exposure to pollution can increase the risk for cardiovascular problems and other diseases.

The research group, led by Ohio State University scientists, has described studies in mice suggesting that chronic exposure to very fine particulate matter triggers events that allow white blood cells to escape from bone marrow and work their way into the bloodstream. Their presence in and around blood vessels alters the integrity of vessel walls and they also collect in fat tissue, where they release chemicals that cause inflammation.

The cellular activity resembles an immune response that has spiraled out of control. A normal immune response to a pathogen or other foreign body requires some inflammation, but when inflammation is excessive and has no protective or healing role, the condition can lead to an increased risk for cardiovascular diseases, diabetes and obesity, as well as other disorders.

Though many questions about the beginning of this process remain unanswered, the scientists predict that the damage may originate in fluid that lines the lung. Tiny molecules in this fluid change structure after being exposed to polluted air, and that change appears to set off this cascade of damaging white blood cell behavior by activating a receptor called "toll-like receptor 4."

The job of toll-like receptor 4, or TLR4, is to recognize specific characteristics of pathogens and then send out signals to activate other players in the immune system. Mice that lack this molecule don't produce as much inflammation after exposure to pollution as do normal mice, suggesting that TLR4 has a prominent role in the body's response to chro
'/>"/>

Contact: Sanjay Rajagopalan
sanjay.rajagopalan@osumc.edu
614-247-7760
Ohio State University
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Polluted air increases obesity risk in young animals
2. Polluted Air Another Danger to U.S. Troops in Iraq
3. Learning Lab of Brentwood Leads Free ADHD Seminar
4. Human Dental Technology Leads to Breakthroughs for Pet Dental Health at Sergeants Pet Care Products, Inc.
5. TechCFO Enters Mid-Atlantic Market; Rick Rolandi Leads DC Metro Office
6. Home Health Agency Owner Pleads Guilty in Connection with Detroit Fraud Scheme
7. New DNA technique leads to a breakthrough in child cancer research
8. AGA leads the way in GI innovation
9. Arsenic exposure activates an oncogenic signaling pathway; leads to increased cancer risk
10. KV Pharmaceutical Subsidiary Pleads Guilty to Two Felonies Regarding Oversized Drugs
11. China's Forbidden City Leads Landmark Climate Action for Earth Hour
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... July 31, 2015 , ... Precision Aesthetics is New York’s only ... was also the first provider of Exilis non-surgical fat reduction in New York. ... has attracted a large International clientele. Many patients travel to New York to ...
(Date:7/31/2015)... GA (PRWEB) , ... July 31, 2015 , ... Sculpted ... , the CoolSmooth PRO this week. Zeltiq Aesthetics released this new applicator in ... in January 2014 for treating the outer thighs. The original applicator required a ...
(Date:7/31/2015)... ... ... Coco Libre announced today that their flagship Organic Coconut Water will be ... Open of Surfing, July 25 through August 2 in Huntington Beach, California. Coco Libre, ... is a natural choice given the Open’s commitment to sustainable practices. , Designated ...
(Date:7/31/2015)... ... July 31, 2015 , ... According to an article published July ... they could reach a consensus on the steps that need to be taken to ... reached 90 percent consensus on a series of steps that each surgeon must complete ...
(Date:7/31/2015)... Dallas, Texas (PRWEB) , ... July 31, 2015 , ... ... Pet Sitter believes community involvement and support of animal welfare organizations is essential to ... for the third consecutive year in the National Association of Professional Pet Sitters (NAPPS) ...
Breaking Medicine News(10 mins):Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 2Health News:Cooler Coolsculpting in Atlanta: Treatments Now Twice As Fast 3Health News:Coco Libre Brings Eco-conscious Hydration to Vans US Open of Surfing 2Health News:Article on Plastic Surgery Consensus Highlights the Duties of Veteran Plastic Surgeons, says Beverly Hills Physicians 2Health News:Article on Plastic Surgery Consensus Highlights the Duties of Veteran Plastic Surgeons, says Beverly Hills Physicians 3Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 2Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 3Health News:Dallas-based Park Cities Pet Sitter Selects Non-Profit Animal Welfare Organization “Angie’s Friends” as this Year’s Recipient of their Presents 4 Pets Supply Drive. 4
... Study finds communication breakdowns at least 7 percent of the ... who visit their primary care physician for routine blood tests ... new study finds. , The failure of doctors and medical ... common," the researchers wrote, even when the results are abnormal ...
... SCHAUMBURG, Ill., June 22 Today Texas Governor Rick Perry signed ... tanning devices for all Texans under the age of 16.5 and ... 16.5 and 18. , , "The American Academy of Dermatology ... the nation to prohibit the use of indoor tanning devices for ...
... , , ... Receive Awards , , MIDDLETOWN, Ohio, June 22 ... Project Muscular Dystrophy (PPMD), the largest non-profit organization in ... muscular dystrophy (Duchenne), announced that PPMD will be honoring United ...
... disorder marked in part by auditory hallucinations and paranoia, can ... when people are ready to stand on their own two ... scientists at UCLA think they are beginning to understand one ... its kind, the researchers used a novel form of brain ...
... Families to Help Their Communities , , WASHINGTON, June ... themselves to meaningful, long-term service to their communities as part ... Eric K. Shinseki spent part of his morning today transporting ... , "We, who enjoy liberty,s blessings, will forever remain in ...
... in just 20% of counties, report finds , MONDAY, June ... HIV may largely depend on where in America you live, ... found that 80 percent of U.S. cases are clustered in ... black, Latino and other minority populations. , The new data ...
Cached Medicine News:Health News:Patients Often Not Told About Abnormal Test Results 2Health News:Patients Often Not Told About Abnormal Test Results 3Health News:American Academy of Dermatology Association Commends Texas for Enacting the Most Restrictive Indoor Tanning Law in the Country 2Health News:Parent Project Muscular Dystrophy Holds 15th Annual Connect Conference in Atlanta 2Health News:Parent Project Muscular Dystrophy Holds 15th Annual Connect Conference in Atlanta 3Health News:Parent Project Muscular Dystrophy Holds 15th Annual Connect Conference in Atlanta 4Health News:Alterations in brain's white matter key to schizophrenia, UCLA study shows 2Health News:VA Secretary Hits the Road to Highlight "United We Serve" Effort 2Health News:HIV 'Atlas' Shows Virus Targeting Minorities 2Health News:HIV 'Atlas' Shows Virus Targeting Minorities 3
(Date:7/31/2015)... According to a new market research report " ... Oxide, Filtration, E-beam, Gamma), Services (Onsite & Offsite), Consumables (Indicators, ... to 2020", published by MarketsandMarkets, The Sterilization Equipment Market is ... a CAGR of 7.6%.from 2015 to 2020. ... ables and 37 F igures ...
(Date:7/31/2015)... SAN DIEGO , July 31, 2015  Eisai ... Ltd. (Headquarters: Tokyo , President and ... Inc. (Headquarters: San Diego, California , ... HALO") have signed a clinical collaboration agreement to evaluate ... in combination with Halozyme,s investigational drug PEGPH20 (PEGylated recombinant ...
(Date:7/30/2015)... Mettler-Toledo International Inc. (NYSE: MTD ) ... are the highlights: , Sales in local ... prior year. Reported sales decreased 4% as currency reduced ... Net earnings per diluted share as reported (EPS) were ... EPS was $2.80 , an increase of 9% ...
Breaking Medicine Technology:Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 2Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 3Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 4Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 2Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 3Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 4Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 5Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 6Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 2Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 3Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 4Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 5Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 6Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 7Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 8Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 9Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 10Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 11Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 12Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 13Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 14
... WALTHAM, Mass., Aug. 16 Interleukin Genetics, Inc. (OTCQB: ILIU) ... common stock will be transferred from the NYSE Amex ... Investors in the Company can trade the stock easily ... be ILIU.  The OTCQB market tier was recently introduced ...
... Pharmaceuticals Reports Strong Second Quarter 2010 Financial Results -- BEIJING, Aug. 16 /PRNewswire-Asia-FirstCall/ -- ... ... --> ... = ,; var first_result; // Results are keyed by longUrl, so we need to grab the ...
Cached Medicine Technology:Interleukin Genetics Moves Trading of Stock to OTCQB Marketplace 2Lotus Pharmaceuticals Reports Strong Second Quarter 2010 Financial Results 2Lotus Pharmaceuticals Reports Strong Second Quarter 2010 Financial Results 3Lotus Pharmaceuticals Reports Strong Second Quarter 2010 Financial Results 4Lotus Pharmaceuticals Reports Strong Second Quarter 2010 Financial Results 5Lotus Pharmaceuticals Reports Strong Second Quarter 2010 Financial Results 6Lotus Pharmaceuticals Reports Strong Second Quarter 2010 Financial Results 7Lotus Pharmaceuticals Reports Strong Second Quarter 2010 Financial Results 8Lotus Pharmaceuticals Reports Strong Second Quarter 2010 Financial Results 9Lotus Pharmaceuticals Reports Strong Second Quarter 2010 Financial Results 10Lotus Pharmaceuticals Reports Strong Second Quarter 2010 Financial Results 11Lotus Pharmaceuticals Reports Strong Second Quarter 2010 Financial Results 12
... Kendall provides hospitals and alternate ... of tracheostomy care trays which offer ... infection control. Designed with the guidance ... total-care trays provide exactly what is ...
For use with cushioned neckband....
Bivona® Uncuffed Neonatal and Pediatric Silicone Tracheostomy Tubes....
Fome-Cuf® tubes can breathe with the patient to provide a safe, effective, and low pressure seal throughout the ventilatory cycle....
Medicine Products: