Navigation Links
Polluted air increases obesity risk in young animals
Date:12/2/2010

ls begins to secrete molecules that send out complex signals. This process can lead to inflammation and, in turn, to insulin resistance or diabetes, as well as other disease conditions. Abdominal, or visceral, fat in particular is closely associated with the development of cardiovascular disease.

The scientists do not yet know whether these effects would be sustained over adult life if air quality circumstances were changed, or if they are otherwise reversible.

"We really wanted to see how this air pollution affects obesity with this early life exposure," Sun said. "In a real-world scenario, it would be very difficult to escape from the pervasive influence of dirty air, an influence that begins very early on in life."

To explore the physiological mechanism behind the pollution's effects on fat cells and inflammation, the researchers tested the same exposure levels in mice that had been genetically modified so they don't carry a gene called p47phox. This gene is a subunit of an enzyme linked to free radicals that lead to the accumulation of inflammatory cells in artery walls and plaque, known as atherosclerosis.

Mice without this gene that were exposed to pollution did not show most of the effects of that exposure that normal mice showed, Sun said.

"When you knock out p47phox, it pretty much alleviates the effects of air pollution," he said. "What this gives us is a potential for future therapeutic options that might target this gene."

More research would be required to further define this mechanism, he noted.

These same researchers do plan to continue studying the effects of fine particulate pollution on health, and have designed a study in humans that will take place in Beijing, China. The project, led by Rajagopalan, will test the effects of air pollution on metabolic syndrome and insulin resistance in patients. Participants will wear personal monitors to gauge their exposure to pollution.


'/>"/>

Contact: Qinghua Sun
sun.224@osu.edu
614-247-1560
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Changes during menopause increases risk of heart disease and stroke
2. Smoking significantly increases risk of aneurysm in people with certain genes
3. Regular analgesic use increases hearing loss in men
4. National Study Reports Staggering Spending Increases Among Seniors With Chronic Conditions Through Original Medicare - Special Needs Plan Program Offers Solution For Those In Texas
5. Delaying post-surgical radiation increases risk of breast cancer recurrence in older women
6. Genetic variant greatly increases lung cancer risk for light smokers
7. Gastric bypass surgery increases risk of kidney stones
8. Studies Show Significant Increases of C. Difficile Infections (CDI)
9. Infertility increases a mans risk of prostate cancer
10. Male Infertility Significantly Increases Risk of Prostate Cancer
11. Sun protection program increases hat use among 4th-graders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... 2015 Robins & Morton Celebrates Women ... Women in Construction Week (March 1-7, sponsored by the ... National Women’s History Month, Robins & Morton is recognizing ... company and the construction industry as a whole. From ... dozens of roles in between, each woman has a ...
(Date:3/2/2015)... 2015 The Workgroup for Electronic Data ... use of health IT to create efficiencies in healthcare ... for Small Providers.” The white paper by WEDI’s ICD-10 ... for ICD-10 testing by focusing on primary considerations and ... with the October 1, 2015 implementation date. Download the ...
(Date:3/2/2015)... March 02, 2015 This year, the National ... and will provide opportunities for people across the country to ... help people with MS live their best lives. MS Awareness ... to inspire others to join the Society’s vision of a ... unpredictable, often disabling disease of the central nervous system, interrupts ...
(Date:3/2/2015)... 2015 Four Seasons Resort Maui at Wailea, ... anniversary this year, having officially opened its doors on March ... is honoring over 70 employees who started on Day 1 ... the approximately 400 original employees. The celebration will be ... , This Four Seasons flagship resort, the first ...
(Date:3/2/2015)... What are the best practices for writing a ... interviews scheduled, how can physicians best prepare, and how ... physicians who are looking for new opportunities can learn ... PracticeLink Physician Career Advancement Workshop and Job Fair on ... 5:30 to 8:30 p.m. at the Marriott-Texas Medical Center ...
Breaking Medicine News(10 mins):Health News:Robins & Morton Recognizes Women In Construction 2Health News:WEDI Releases New White Paper on ICD-10 Testing for Small Providers 2Health News:Every Connection Counts During MS Awareness Week 2Health News:Every Connection Counts During MS Awareness Week 3Health News:Every Connection Counts During MS Awareness Week 4Health News:Celebrating Four Seasons Resort Maui’s 25th Anniversary 2Health News:PracticeLink to Host a Career Advancement Workshop and Job Fair in Houston 2
... Ablation Frontiers, Inc., a,privately-held medical device company, ... using the company,s Tip-Versatile Ablation,Catheter(TM) (T-VAC). Dr. ... in,Chertsey, United Kingdom is one of three ... new multi-electrode linear ablation catheter since,November 2007. ...
... One of Australia,s largest,pharmacy groups, Chemmart, has introduced a ... posed by discount chains., The system was launched ... participating pharmacies signed up more than 30,000 Chemmart,"rewards" members., ... has now been,rolled out to more than 160 Chemmart ...
... 16 The Ninth Annual Renal Teen,Prom, "Winter ... is,to be held Sunday, January 20, 2008 at ... unique event attracts more than 350 kidney teens,(ages ... a transplant, and,their guests, coming from Washington D.C., ...
... Americans consume more calories as a,nation on Super Bowl Sunday ... the time the final whistle blows at Super Bowl XLII,Americans ... chicken wings, and beer., But this year you have ... field 109 times to burn off all of those extra ...
... life for kids with moderate to severe disease, , , ... significantly improved psoriasis symptoms in children under 17 with ... The study found that 57 percent of the children ... a 75 percent improvement in their symptoms, and their ...
... a 23% reduced risk of falling in winter, spring ... may help reduce the risk of falls among high-risk elderly ... than 65 fall each year, and six percent sustain a ... of falling is a major problem in older people," according ...
Cached Medicine News:Health News:Speedy Procedures Demonstrate Excitement and Continued Interest in Novel Multi-Electrode Ablation System 2Health News:Chemmart(R) Sees Instant Results From Launch of New Rewards Program 2Health News:Celebrities to Attend the Ninth Annual Kidney Teen Prom 2Health News:Eat This, Not That!(TM): 5 Smart Super Bowl Swaps That Will Save You Hundreds of Calories 2Health News:Adult Drug Effective in Treating Psoriasis in Children 2Health News:Adult Drug Effective in Treating Psoriasis in Children 3Health News:Vitamin D May Curb Falls in High-Risk Older Women 2
(Date:3/2/2015)... BETHESDA, Md. , March 2, 2015 ... on treating and preventing autoimmune diseases, announced today that ... (AMG 714) from Amgen (NASDAQ: AMGN ). ... has the rights to develop, manufacture and commercialize AMG ... . Concurrently, Amgen has been granted an exclusive ...
(Date:3/2/2015)... Texas , March 2, 2015   Lexicon ... biopharmaceutical company focused on developing breakthrough treatments for human ... 2014 financial results on Wednesday, March 4, 2015 before ... conference call and webcast to discuss clinical development progress ... end of 2014 at 10:00 a.m. Eastern Time on ...
(Date:3/2/2015)... 2, 2015  BioMed Realty Trust, Inc. (NYSE: ... 313,000 square feet of space in the most dynamic ... world through the termination of Vertex Pharmaceuticals, leases on ... effective February 28, 2015. BioMed Realty will receive a ... begin to reposition the properties to meet the growing ...
Breaking Medicine Technology:Celimmune Announces Anti-IL-15 Antibody Licensing and Option Agreements with Amgen 2Celimmune Announces Anti-IL-15 Antibody Licensing and Option Agreements with Amgen 3Lexicon To Report Fourth Quarter And Year End 2014 Financial Results On March 4, 2015 2BioMed Realty Gets Back 313,000 Square Feet Of Valuable Real Estate In Cambridge Innovation District 2BioMed Realty Gets Back 313,000 Square Feet Of Valuable Real Estate In Cambridge Innovation District 3
... 13 Anadys Pharmaceuticals, Inc. (Nasdaq: ANDS ) ... Annual Healthcare Conference on Friday, September 17, 2010 at 8:35 ... at the Four Seasons in Boston.  Steve Worland, Ph.D., President ... of Anadys and its clinical development programs. Dr. ...
... Amgen (Nasdaq: AMGN ) will participate in ... the St. Regis New York in New York City, beginning ... president of Global Development, for Amgen, will present at the ... the Internet and can be accessed from Amgen,s website, ...
Cached Medicine Technology:Anadys Pharmaceuticals to Present at Two Upcoming Investor Conferences 2
... nebulizer system offers an affordable and ... COPD or other respiratory conditions. The ... gives patients the ability to take ... Its unique nebulizer design delivers powerful ...
... The most compact, portable DC powered ... Elite provides the freedom to take ... system is powered by the included ... Adapter and Battery Kit. The integral ...
... The 50 psi MaxiCompressor, the ... to run 24 hours a ... It features a tamper-proof locking ... unintentional increases or decreases in ...
... PulmoStar is a low cost compressor/nebuliser which offers ... the home, health centre or clinic. The SunMist ... and a simple filter change every six months., ... With Disposable Neb, 3 Prong Polarized plug With ...
Medicine Products: