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Polluted air increases obesity risk in young animals
Date:12/2/2010

h of a human hair -- these particles could reach deep areas of the lungs and other organs in the body.

For this study, researchers obtained baseline measures of the mice for their weight, blood sugar and body fat at the start of the experiment. After exposing the animals to polluted or filtered air for 10 weeks, researchers analyzed the mice for a number of risk factors associated with obesity and insulin resistance, the hallmark of Type 2 diabetes.

As expected, mice on the high-fat diet gained much more weight than those on the normal diet. But mice exposed to polluted air and eating the normal diet had more significant elevations in glucose -- sugar in their blood -- than did normal-diet mice that breathed clean air. They also showed more signs of insulin resistance based on an index that measures both sugar and insulin in the blood at the same time.

Insulin resistance results when the presence of insulin does not initiate the transfer of glucose from the blood into the tissues, where it is used for energy.

Mice exposed to pollution -- regardless of which diet they ate --also had higher blood levels of tumor necrosis factor-alpha, a protein involved in systemic inflammation, than did mice breathing clean air.

In addition, both abdominal and subcutaneous (under the skin) types of fat were increased with exposure to pollution in mice, even in animals that ate the normal diet. Mice eating a high-fat diet also had more fat, but their exposure to polluted air did not exacerbate those effects.

"These findings suggest that fine particulate pollution exposure alone, in the presence of a normal diet, may lead to an increase in fat cell size and number, and also have a proinflammatory effect," said Sanjay Rajagopalan, senior author of the study and the John W. Wolfe Professor of Cardiovascular Medicine at Ohio State.

Fat cell size and quantity is important in many diseases because the tissue made up of fat cel
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Contact: Qinghua Sun
sun.224@osu.edu
614-247-1560
Ohio State University
Source:Eurekalert

Page: 1 2 3

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