Navigation Links
Poliovirus vaccine trial shows early promise for recurrent glioblastoma
Date:5/21/2013

DURHAM, N.C. An attack on glioblastoma brain tumor cells that uses a modified poliovirus is showing encouraging results in an early study to establish the proper dose level, researchers at Duke Cancer Institute report.

The treatment, developed at Duke and tested in an ongoing phase 1 study, capitalizes on the discovery that cancer cells have an abundance of receptors that work like magnets drawing the poliovirus, which then infects and kills the cells.

The investigational therapy, known as PVSRIPO, uses an engineered form of the virus that is lethal to cancer cells, while harmless to normal cells. Infused directly into the patient's tumor, the virus-based therapy also triggers the body's immune fighters to launch an attack against the infected tumor cells.

Preliminary data, presented at the upcoming 2013 Annual Meeting of the American Society of Clinical Oncology in Chicago (ASCO abstract #2094), previews the results of seven patients enrolled in the study whose tumors reoccurred despite traditional treatments for glioblastoma multiforme, the most common and aggressive brain tumor.

Of the patients enrolled in the study, three have responded well to the drug. One patient remains disease-free 12 months after treatment, another 11 months post-treatment and the third is disease-free after five months. With traditional treatment, about half of glioblastoma patients see recurrent tumor growth within eight weeks.

Two patients in the study did not fair as well; one had recurrent tumor growth after two months, and another's condition declined after four months. The remaining two patients have been treated in the last three and two months, respectively, and currently remain disease free.

"These early results are intriguing," said Annick Desjardins, M.D., FRCPC, principal investigator and associate professor of medicine at Duke University School of Medicine. "Current therapies for glioblastoma are limited because they cannot cross the blood-brain barrier and often do not specifically attack the tumor. This treatment appears to overcome those problems. We are eager to see additional results as we move forward with our study."


'/>"/>

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Related medicine news :

1. Study: Older Whooping Cough Vaccine More Effective
2. Whole-cell vaccine was more effective than acellular vaccine during CA pertussis outbreak
3. Cocaine vaccine passes key testing hurdle
4. Immune Cell Discovery May One Day Lead to Herpes Vaccine: Study
5. TransactRx Releases Part 1 of Series – Buying Vaccines from Group Purchasing Organizations
6. TB, HIV and malaria vaccine research gets major boost
7. Flu Vaccine Safe for Kids With Crohns, Colitis: Study
8. Flu vaccine safe for children with IBD: Study
9. Focus on STD, not cancer prevention, to promote HPV vaccine use
10. Study compares effectiveness of 2 vs. 3 doses of HPV vaccine for girls and young women
11. Nottingham-China research collaboration holds hope for bovine and human TB vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... ... March 23, 2017 , ... The TouchPoint Solution, home of ... manage stress and anxiety. , “Buzzies change the way we interact with stress ... Buzzies. , Since its launch date in December 2016, The TouchPoint Solution has sold ...
(Date:3/23/2017)... CA (PRWEB) , ... March 23, 2017 , ... ... management and workflow solutions, today named The Resource Group as their 2016 Microsoft ... and partner conference in Newport Beach, CA. The award recognizes The Resource ...
(Date:3/23/2017)... ... 23, 2017 , ... According to the National Sleep Foundation , poor ... the only cause of the sunken-eye look, which can include dark circles or bags ... poor health are likely due to genetics, dehydration, allergies, and losing fat beneath the ...
(Date:3/23/2017)... CA (PRWEB) , ... March 23, 2017 , ... ... FACIS Monthly Monitoring Healthcare products at competitive pricing. Verisys through ... sanctions, Exclusions, Debarments, License restrictions and Disciplinary actions. , “We are delighted to ...
(Date:3/23/2017)... ... March 23, 2017 , ... On 2 March ... the US Special Operations Command’s Patriot Award. The award was presented by the ... Force Dagger Foundation for its significant and enduring support to the command. ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... , March 23, 2017   BioSpace , ... resource, has partnered with Indiana Biosciences Research Institute ... organizations and educational institutions to bring the state,s ... first-ever BioIndiana Hotbed map, an artistic representation of the ... was presented to Vice President Mike Pence , ...
(Date:3/23/2017)... 2017  Digital Pharmacist Inc. ( ... growing digital health company, announced today that it ... patients to manage their prescriptions. Over three hundred ... Health Pharmacy, USave Pharmacy and Owen,s Healthcare use ... accelerate its product development schedule, the company now ...
(Date:3/23/2017)... Research and Markets has announced the addition of the "Global ... ... therapy devices market to grow at a CAGR of 10.16% during ... Devices Market 2017-2021, has been prepared based on an in-depth market ... landscape and its growth prospects over the coming years. The report ...
Breaking Medicine Technology: