Navigation Links
Plvap/PV1 critical to formation of the diaphragms in endothelial cells
Date:1/3/2013

  • PV1 expression in vascular endothelium is required for survival
  • PV1 is required for the formation of stomatal and fenestral diaphragms
  • Lack of diaphragms in fenestrated endothelia causes vascular leak of plasma proteins
  • Vascular leak results in severe hypoproteinemia and hypertriglyceridemia

Dartmouth scientists have demonstrated the importance of the gene Plvap and the structures it forms in mammalian physiology in a study published in December by the journal Developmental Cell.

"The knowledge generated and the animal models created will allow a better understanding of the role of the gene in diseases and will help validate its usefulness as a therapeutic or diagnostic target," said lead author Radu V. Stan, MD, associate professor, Geisel School of Medicine at Dartmouth, and member of the Dartmouth-Hitchcock Norris Cotton Cancer Center (NCCC).

The study demonstrates that plasmalemma vesicle associated protein (PV1), a vertebrate gene specifically expressed in the vascular endothelial cells, is critical for the formation of the diaphragms of endothelial caveolae, fenestrae and transendothelial channels. Although discovered in the 1960s by electron microscopy, the function of the diaphragms was previously unknown. Using mice with loss and gain of PV1 function Dartmouth scientists demonstrated that the diaphragms of fenestrae are critical for maintenance of basal permeability, the homeostasis of blood plasma in terms of protein and lipid blood composition, and ultimately survival.

PV1 has newly discovered roles in cancer and in various infectious and inflammatory diseases. "The knowledge generated and the animal models created will allow a better understanding of the role of the gene in these diseases and to validate its usefulness as a therapeutic or diagnostic target," said Stan.

In the absence of such diaphragms, plasma protein extravasation produces a noninflammatory protein-losing enteropathy resulting in protein calorie malnutrition and ultimately death.

"Our results and the mouse models we have created provide the foundations for evaluating numerous aspects of basal permeability in fenestrated vascular beds," said Stan.


'/>"/>

Contact: Donna M. Dubuc
donna.m.dubuc@hitchcock.org
603-653-3615
Dartmouth-Hitchcock Medical Center
Source:Eurekalert

Related medicine news :

1. Newly Updated 'Critical Bench' Teaches People How to Gain Muscle, Says Tony Nguyen
2. Neurocritical Care & Stroke Conference slated for March 2013
3. FDA Clears Laser for all Critical Steps in Cataract Surgery: Center For Sight Performs the Most LENSAR Laser Procedures in U.S.
4. Dynarex Corporation & Group Purchasing of American Team up with Critical Medical Products for Hurricane Sandy Disaster Relief
5. Combating a crisis: Global burden of preterm birth can be reduced if critical actions are taken
6. RI Hospital: Near-complete blood flow restoration critical for best outcomes in stroke
7. Vitamin D in Pregnancy Critical for Brain Development, Study Says
8. First pediatric study to look at the role of vitamin D in critical illness
9. New technique helps determine degree of muscle wasting in critically ill patients
10. Wayne State researchers say adolescent smoking prevention programs still critical
11. ASH launches multi-million-dollar grant program to support critical blood disease research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... (PRWEB) , ... February 12, ... ... Foundation today announced a new initiative—the Siemens Foundation-PATH Ingenuity Fellowships—to develop the ... partnership will recruit top students from U.S. universities who will draw from ...
(Date:2/12/2016)... ... February 12, 2016 , ... Each year, the American ... held in Anaheim, CA at the Anaheim Convention Center. Almost 10,000 physical therapists across ... therapy products in action, learn more about their chosen field and network with their ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... Series at Zuckerberg San Francisco General Hospital on April 5-7. The series is ... and create new habits. The workshops cover a broad range of topics, including ...
(Date:2/12/2016)... ... February 12, 2016 , ... AssureVest Insurance Group, a locally ... a charity drive that will raise funds earmarked to purchase computers and software for ... School. , “My school is in a low-income area and has more than 60 ...
(Date:2/12/2016)... PA (PRWEB) , ... February 12, 2016 , ... ... families of the Pittsburgh metro area, celebrates the beginning of the latest charity ... children develop social skills through art. Donations to this worthy cause are currently ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... Ambulances announces its first delivery in the state of ... Emergency Medical Services (EMS) consisting of four vehicles: three ... Emergency Vehicles in Lecanto, FL , USA, ... the latest in Demers, ongoing expansion of sales.  ... --> Benoit LaFortune , Executive Vice President at Demers. ...
(Date:2/12/2016)... -- Memorial Hermann Health System has teamed up with Houston ... a one-of-a-kind experience to pediatric patients at Children,s ... 360-degree video and Google Cardboard, Howard was able to ... the patients and their families an unexpected, and energetically ... video . Memorial Hermann IRONMAN Sports ...
(Date:2/12/2016)... , Feb. 12, 2016  Aralez Pharmaceuticals Inc. (Nasdaq: ... announced the Company will ring the Nasdaq Closing Bell ... New York at 4:00 p.m. ET on ... Aralez. Adrian Adams , will perform ... 3:50 to 4:00 p.m. ET.  A live webcast will ...
Breaking Medicine Technology: