Navigation Links
Pluripotent stem cell-derived neurons may be a viable Parkinson's disease treatment

Putnam Valley, NY. (Jun. 28 2013) A team of researchers from Rush University, Yale University, the University of Colorado and the St. Kitts Biomedical Research Foundation transplanted human embryonic stem cells into primate laboratory animals modeled with Parkinson's disease and found "robust survival" of the cells after six weeks and indications that the cells were "well integrated" into the host animals. The study appears as an early e-publication for the journal Cell Transplantation, and is now freely available on-line at

"Parkinson's disease was one of the first neurological disorders to be studied for potential replacement of lost neurons," said Dr. D. Eugene Redmond of Yale University School of Medicine. "Since the 1970s there has been significant progress with learning the required gene expression, growth factors and culture conditions for differentiating cells into apparent dopamine neurons."

However, the researchers noted that transplanted dopamine neurons have not produced "long-lasting midbrain specific neurons when transplanted into rodents or monkeys" and there have only been pilot reports of functional improvement.

According to the study authors, their study tested the long-term survival and functional benefit of apparent dopamine neurons in monkeys modeled with Parkinson's disease. As with other studies, their results found that the gene expression of the rate limiting synthetic enzyme for dopamine production, tyrosine hydroxylase (TH), was "transient" after transplantation, raising questions about the optimal cell stage and culture environment that favor graft survival and the factors that could impact cell transplantation. Once more, a more robust immunosuppression regimen than employed in other primate studies resulted in better cell survival.

"Our results demonstrate that pluripotent stem cell line-derived neurons retain the capacity to robustly survive and respond to cues in the primate brain," they wrote. "The absence of TH expression indicates that other methods may be necessary to produce and maintain the proper midbrain dopaminergic form of the cells in vivo."

While their study demonstrated robust survival of the cells, the researchers said that longer term studies are required to better understand what factors may impact long-term function replacement and whether they demonstrate significant reversal of parkinsonism, tumor formation or dyskinesias, the latter being a side effect of current treatments for Parkinson's Disease.


Contact: Robert Miranda
Cell Transplantation Center of Excellence for Aging and Brain Repair

Related medicine news :

1. Induced Pluripotent Stem Cell Industry (iPSC Market) Report Updated for 2013 Now Available at
2. Scientists at UMass Medical School identify neurons that control feeding behavior in Drosophila
3. Researchers identify networks of neurons in the brain that are disrupted in psychiatric disease
4. Tiny worm sheds light on giant mystery about neurons
5. Stanford researchers turn skin cells directly into the cells that insulate neurons
6. Fatheads: How neurons protect themselves against excess fat
7. Difficulty in recognizing faces in autism linked to performance in a group of neurons
8. Improper protein digestion in neurons identified as a cause of familial Parkinsons
9. Protein build-up leads to neurons misfiring
10. Neurons derived from cord blood cells may represent new therapeutic option
11. Neurons that control overeating also drive appetite for cocaine
Post Your Comments:
(Date:6/26/2016)... ... 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop ... The fitness app plans to fix the two major problems leading the fitness industry today:, ... all type program , They don’t eliminate all the reasons people quit their ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a method ... —Johnson is one of the first doctors to perform the treatment. Orthobiologics are ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced ... feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as a ... has released tools for healthy coping following a traumatic event. , Trauma sufferers tend ...
(Date:6/24/2016)... ... 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida ... their peers for this recognition are considered among the top 2 percent of lawyers ... as members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 The Academy of Managed Care ... that would allow biopharmaceutical companies to more easily ... make formulary and coverage decisions, a move that addresses ... medicines. The recommendations address restrictions in the ... the drug label, a prohibition that hinders decision makers ...
(Date:6/24/2016)... Mass. and SAN CLEMENTE, Calif. , ... California -based mobile pulmonary function testing company, is now able ... PFT devices developed by ndd Medical Technologies , Inc. ... testing done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® ... , can get any needed testing done in the comfort ...
(Date:6/24/2016)... , June 24, 2016 ... Market by Type (Standard Pen Needles, Safety Pen Needles), ... (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) ... MarketsandMarkets, This report studies the market for the forecast ... to reach USD 2.81 Billion by 2021 from USD ...
Breaking Medicine Technology: