Navigation Links
Plavix, Heartburn Drug Safe to Take Together: Study
Date:9/21/2010

By Steven Reinberg
HealthDay Reporter

TUESDAY, Sept. 21 (HealthDay News) -- A new study finds it's safe to take the blood thinner Plavix with proton-pump inhibitors like Nexium, contrary to recent research that said the combination compromised Plavix's effectiveness.

"We looked into this highly debated area of clopidogrel [Plavix] and proton-pump inhibitors," said lead researcher Dr. Mette Charlot from the department of cardiology at Copenhagen University Hospital Gentofte in Hellerup, Denmark. "We did not find any evidence of drug interaction."

Proton-pump inhibitors are heartburn drugs. Doctors often prescribe the two drugs in combination to prevent clotting and reduce the risk of stomach bleeding, which can be a serious complication for patients taking Plavix, the researchers said.

This study is larger than studies that found an interaction between the drugs, and this data included patients who were taking PPIs but not Plavix, Charlot noted.

"What we actually found was an increased risk related to the use of proton-pump inhibitors, but we found the risk was the same in patients treated with clopidogrel and patients not treated with clopidogrel," Charlot said.

For the study, published in the Sept. 21 issue of the Annals of Internal Medicine and funded by the Danish Medical Research Council and the Danish Heart Foundation, Charlot's team collected outcome data on 56,406 patients across Denmark who had a first heart attack between 2000 and 2006. Follow-up was one year.

Sixteen percent were rehospitalized for a heart attack or stroke, or died. Of the 44 percent of patients who took Plavix, 27 percent also took a PPI, the researchers say.

Patients taking both medications had a 29 percent increased risk of rehospitalization for a heart attack or stroke, or death. However, among patients taking only a PPI, the risk of these adverse events was also 29 percent, the researchers found.

The researchers concluded that the increased risk of a heart attack, stroke or death is associated with PPIs, and not the combination of Plavix and a PPI.

"We are confident that the feared interaction between the two drugs does not happen," Charlot said. "We believe that patients who have an indication for PPI treatment should definitely be treated with PPIs to avoid the risk of gastrointestinal bleeding," she added.

Dr. James Brophy, a professor of medicine and epidemiology at the Royal Victoria Hospital in Montreal, Canada, said this new research carries more weight than the earlier studies.

This study "appears to be of superior quality to several previous reports," said Brophy, author of an accompanying journal editorial. "There is not high quality evidence supporting a meaningful drug interaction between clopidogrel and PPIs," he said.

"While unnecessary drug prescribing is always to be avoided, the current evidence suggests that patients taking clopidogrel can take a PPI," Brophy said.

Additional studies would be helpful, Brophy added, "but in the interim, the dangers of bleeding from avoiding PPIs may well be greater than any cardiac risks from inhibiting clopidogrel."

More information

For more information on the Plavix-PPI combo, visit the U.S. Food and Drug Administration.

SOURCES: Mette Charlot, M.D., department of cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark; James Brophy, M.D., Ph.D., professor, medicine and epidemiology, Royal Victoria Hospital, Montreal; Sept. 21, 2010, Annals of Internal Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. FDA Warns of Fracture Risk With Popular Heartburn Drugs
2. Coming Soon: A Low-Heartburn Coffee?
3. A century-old puzzle comes together: Scientists ID potential protein trigger in lung disease sarcoidosis
4. Study Claims Flu Shots Associated With Lower Risk of Heart Attack
5. Investigational eye treatment: Corneal collagen crosslinking research study
6. For Common Warts, Freezing Therapy Works Best: Study
7. Study: How Palestinian and Israeli children are psychologically scarred by exposure to war
8. Study: Mental illness stigma entrenched in American culture; new strategies needed
9. Successful periodontal therapy may reduce the risk of preterm birth, according to Penn dental study
10. New study finds positive return on investment for states that invest in quit smoking treatments
11. In Vitro Fertilization Success Rate Higher in Spring, Study Suggests
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Plavix, Heartburn Drug Safe to Take Together: Study
(Date:9/22/2017)... ... September 22, 2017 , ... TopConsumerReviews.com ... by Native Remedies that helps promote pancreatic health and regulate blood sugar ... some prescription-based approaches can have negative side effects, and with the changes in ...
(Date:9/22/2017)... (PRWEB) , ... September 22, 2017 , ... “Letters From ... all people, even the lost, have value to God. “Letters From Home” is the ... and a member of the President’s Cabinet of Jerry Savelle Ministries International, who has ...
(Date:9/21/2017)... (PRWEB) , ... September 21, 2017 , ... 38-Year-Old Plastic ... Surgery Center in Naples, Florida is pleased to announce that Plastic Surgeon Kiranjeet Gill ... 40 Under 40 is an annual award that was started in 2003 ...
(Date:9/21/2017)... ... 2017 , ... Hair restoration surgery is having a moment, ... International Society of Hair Restoration Surgery (ISHRS). The worldwide volume of ... 635,189 procedures performed in 2016. , "Like other forms of cosmetic surgery ...
(Date:9/21/2017)... ... ... The New England Center for Children® (NECC®), a global leader in education ... the Board of Directors. , “The New England Center for Children is honored ... addition to our team,” said Vincent Strully, Jr., President and CEO of The New ...
Breaking Medicine News(10 mins):
(Date:9/9/2017)... YORK , Sept. 8, 2017 Dealmed ... largest independent supplier of medical equipment, supplies, drugs, vaccines, ... it has entered into an agreement to acquire Vantage ... equipment based in Holtsville, New York ... specializes in supplying new and emerging medical practices, will ...
(Date:9/7/2017)... Caris Life Sciences, a leading innovator ... of precision medicine, today announced results from two ... molecular profiling approach in guiding therapeutic strategies in ... (CGP+) with Caris Molecular Intelligence ® to ... level, leading to more therapeutic options and improved ...
(Date:9/6/2017)... , Sept. 6, 2017  Robert G. Szewc, ... Pinnacle Professional Member in recognition of his contributions to ... serves as a Nephrologist at the practice of Kidney ... medicine, kidney care and hypertension solutions. He has worked ... years of career experience, as well as expertise in ...
Breaking Medicine Technology: