Navigation Links
Plavix, Heartburn Drug Safe to Take Together: Study
Date:9/21/2010

By Steven Reinberg
HealthDay Reporter

TUESDAY, Sept. 21 (HealthDay News) -- A new study finds it's safe to take the blood thinner Plavix with proton-pump inhibitors like Nexium, contrary to recent research that said the combination compromised Plavix's effectiveness.

"We looked into this highly debated area of clopidogrel [Plavix] and proton-pump inhibitors," said lead researcher Dr. Mette Charlot from the department of cardiology at Copenhagen University Hospital Gentofte in Hellerup, Denmark. "We did not find any evidence of drug interaction."

Proton-pump inhibitors are heartburn drugs. Doctors often prescribe the two drugs in combination to prevent clotting and reduce the risk of stomach bleeding, which can be a serious complication for patients taking Plavix, the researchers said.

This study is larger than studies that found an interaction between the drugs, and this data included patients who were taking PPIs but not Plavix, Charlot noted.

"What we actually found was an increased risk related to the use of proton-pump inhibitors, but we found the risk was the same in patients treated with clopidogrel and patients not treated with clopidogrel," Charlot said.

For the study, published in the Sept. 21 issue of the Annals of Internal Medicine and funded by the Danish Medical Research Council and the Danish Heart Foundation, Charlot's team collected outcome data on 56,406 patients across Denmark who had a first heart attack between 2000 and 2006. Follow-up was one year.

Sixteen percent were rehospitalized for a heart attack or stroke, or died. Of the 44 percent of patients who took Plavix, 27 percent also took a PPI, the researchers say.

Patients taking both medications had a 29 percent increased risk of rehospitalization for a heart attack or stroke, or death. However, among patients taking only a PPI, the risk of these adverse events was also 29 percent, the researchers found.

The researchers concluded that the increased risk of a heart attack, stroke or death is associated with PPIs, and not the combination of Plavix and a PPI.

"We are confident that the feared interaction between the two drugs does not happen," Charlot said. "We believe that patients who have an indication for PPI treatment should definitely be treated with PPIs to avoid the risk of gastrointestinal bleeding," she added.

Dr. James Brophy, a professor of medicine and epidemiology at the Royal Victoria Hospital in Montreal, Canada, said this new research carries more weight than the earlier studies.

This study "appears to be of superior quality to several previous reports," said Brophy, author of an accompanying journal editorial. "There is not high quality evidence supporting a meaningful drug interaction between clopidogrel and PPIs," he said.

"While unnecessary drug prescribing is always to be avoided, the current evidence suggests that patients taking clopidogrel can take a PPI," Brophy said.

Additional studies would be helpful, Brophy added, "but in the interim, the dangers of bleeding from avoiding PPIs may well be greater than any cardiac risks from inhibiting clopidogrel."

More information

For more information on the Plavix-PPI combo, visit the U.S. Food and Drug Administration.

SOURCES: Mette Charlot, M.D., department of cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark; James Brophy, M.D., Ph.D., professor, medicine and epidemiology, Royal Victoria Hospital, Montreal; Sept. 21, 2010, Annals of Internal Medicine


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. FDA Warns of Fracture Risk With Popular Heartburn Drugs
2. Coming Soon: A Low-Heartburn Coffee?
3. A century-old puzzle comes together: Scientists ID potential protein trigger in lung disease sarcoidosis
4. Study Claims Flu Shots Associated With Lower Risk of Heart Attack
5. Investigational eye treatment: Corneal collagen crosslinking research study
6. For Common Warts, Freezing Therapy Works Best: Study
7. Study: How Palestinian and Israeli children are psychologically scarred by exposure to war
8. Study: Mental illness stigma entrenched in American culture; new strategies needed
9. Successful periodontal therapy may reduce the risk of preterm birth, according to Penn dental study
10. New study finds positive return on investment for states that invest in quit smoking treatments
11. In Vitro Fertilization Success Rate Higher in Spring, Study Suggests
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Plavix, Heartburn Drug Safe to Take Together: Study
(Date:6/24/2016)... ... 2016 , ... Comfort Keepers® of San Diego, CA is excited to announce ... program to drive cancer patients to and from their cancer treatments. Comfort Keepers ... of life and ongoing independence. Getting to and from medical treatments is one ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® ... Group (TGIG), has initiated cultivation and processing operations at its production facility, and ... Nevada. , Puradigm is the manufacturer of a complete system of proactive air ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... is supporting the upcoming 2016 Miss Arizona pageant as its official Medspa Sponsor. ... Scottsdale, Tempe, Mesa, and Chandler, Arizona. , Dr. Olson says the decision ...
(Date:6/24/2016)... AZ (PRWEB) , ... June 24, 2016 , ... SpiritQuest ... the heart of West Sedona, surrounded by famous vortex sites: Cathedral Rock, Airport Mesa, ... from partner properties – the Lodge at Sedona as well as the Sedona Rouge, ...
(Date:6/23/2016)... TX (PRWEB) , ... June 23, 2016 , ... The ... and business clients throughout Jasper County and the surrounding region, is initiating a charity ... charity drive will raise funds earmarked for a scholarship fund that will be presented ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced the addition of ... Forecast to 2022" report to their offering. ... date financial data derived from varied research sources to present ... impact on the market during the next five years, including ... sub markets, regional and country level analysis. The report provides ...
(Date:6/23/2016)... , June 23, 2016 Bracket , ... launch its next generation clinical outcomes platform, Bracket eCOA (SM) ... held on June 26 – 30, 2016 in ... first electronic Clinical Outcome Assessment product of its kind to ... #715. Bracket eCOA 6.0 is a flexible platform ...
(Date:6/23/2016)... and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of ... Farma Brasil as the company,s second affiliate in Latin America . ... ... Manager of Astellas Farma Colombia ... ...
Breaking Medicine Technology: