Navigation Links
Platinum and blue light combine to combat cancer
Date:12/9/2010

When it comes to health care blue lights, are usually most useful on the top of ambulances but now new research led by the University of Warwick has found a way to use blue light to activate what could be a highly potent platinum-based cancer treatment.

Research led by the University of Warwick, along with researchers from Ninewells Hospital Dundee, and the University of Edinburgh, have found a new light-activated platinum-based compound that is up to 80 times more powerful than other platinum-based anti-cancer drugs and which can use "light activation" to kill cancer cells in a much more targeted way than similar treatments.

The University of Warwick team had already found a platinum-based compound that they could activate with ultra-violet light but that narrow wave length of light would have limited its use.

Their latest breakthrough has discovered a new platinum based compound known as trans,trans,trans-[Pt(N3)2(OH)2(py)2] that can be activated by normal visible blue, or even green, light. It is also stable and easy to work with, and it is water soluble so it can simply dissolve and be flushed out of the body after use.

The University of Warwick researchers passed the new compound to colleagues at Ninewells Hospital Dundee, who tested it on oesophageal cancer cells cultivated within lab equipment. Those tests show that once activated by blue light the compound was highly effective requiring a concentration of just 8.4 micro moles per litre to kill 50% of the cancer cells.

The researchers are also beginning to examine the compound's effectiveness against ovarian and liver cancer cells. Early results there are also excellent but that testing work is not yet complete.

Professor Peter Sadler, from the Department of Chemistry from University of Warwick, who led the research project, said:

"This compound could have a significant impact on the effectiveness of future cancer treatments. Light activation provides this compound's massive toxic power and also allows treatment to be targeted much more accurately against cancer cells."

"The special thing about our complex is that it is not only activated by ultra-violet light, but also by low doses of blue or green light. Light activation generates a powerful cytotoxic compound that has proven to be significantly more effective than treatments such as cisplatin."

"We believe that photoactivated platinum complexes will make it possible to treat cancers that have previously not reacted to chemotherapy with platinum complexes," says Sadler. "Tumors that have developed resistance to conventional platinum drugs could respond to these complexes and with less side-effects."


'/>"/>

Contact: Professor Peter Sadler
P.J.Sadler@warwick.ac.uk
44-079-139-44357
University of Warwick
Source:Eurekalert

Related medicine news :

1. Ocean Park – Delaware's First Privately Owned Platinum LEED Certified Office Park
2. ClearWay Minnesota(SM) Shines a Spotlight on a Reinvented Tobacco Industry
3. Cyndi Lauper, Lady Gaga Put Spotlight on Women and HIV
4. Virtual Global Highlights Top Ten Misconceptions about Cloud Computing
5. Research highlights role of protein pair in obesity regulation
6. Highlights of major physics conference in Washington, D.C.
7. Defective signaling pathway sheds light on cystic fibrosis
8. Lack of morning light keeping teenagers up at night
9. Fluorescent probes light up cancerous tumors
10. Lighthouse To Help Relief Efforts In Haiti
11. New Lumension Webcast Highlights Key Steps to Prepare Healthcare Firms and Business Associates to Comply with New HITECH Act
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... The American Board of Family Medicine's (ABFM) Board of Directors has selected Warren ... James C. Puffer upon his retirement. Dr. Newton will serve in the position of ... end of 2018. Upon assuming the role of President and CEO on January 1, ...
(Date:10/13/2017)... ... ... PurhealthRX , a leading Health and Nutrition Company, is announcing the ... spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing the amount ... into liquid products, while reducing costs to end users. , The team of researchers ...
(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of ... ElderCounsel, a national organization of elder law and special needs planning attorneys. “Membership in ... It also provides a forum to network with elder law attorneys nationwide,” said Somekh. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term ... long-term care insurance companies have a waiver for care if the client has a ... when the family pays for care, is often waived, so the benefits from their ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional women, ... towards gender equality at their inaugural Summit in New York City in June. The ... social audience of over 3 million. To watch the Mobilize Women video, click ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... , Oct. 4, 2017 ... single-use, self-contained, illuminating medical devices, today announced regulatory ... Health Surveillance Agency (or Agência Nacional de Vigilância ... first single-use, cordless surgical retractor with integrated LED ... optimal access, illumination and exposure of a tissue ...
(Date:10/2/2017)... Denmark , Oct. 2, 2017 The Rebound ... in the struggle to reverse the tide of prescription drug ... for regulating their medicine intake and stepping down their dosage ... set to launch in December 2017; the first 100,000 people ... Learn more at http://www.rebound-solution.com/ ...
(Date:9/25/2017)... , Sept. 25, 2017   Montrium , ... File solutions, today—from the IQPC Trial Master Files ... , NL)—announced that EastHORN Clinical Services has selected ... programs and TMF management. EastHORN, a leading European ... platform to increase transparency to enable greater collaboration ...
Breaking Medicine Technology: