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Plasma protein appears to be associated with development and severity of Alzheimer's disease
Date:7/5/2010

l cortex, which plays a role in memory. In addition, increased clusterin levels in the plasma were associated with having more amyloid-betawhich forms the brain plaques associated with Alzheimer's diseasein the brain's medial temporal lobe.

According to the authors, "previous studies suggest that clusterin belongs to a family of extracellular chaperones," proteins that regulate the formation and removal of amyloid. "Although these findings do not support the clinical utility of plasma clusterin concentration as a stand-alone biomarker for Alzheimer's disease, they reveal a robust peripheral signature of this amyloid chaperone protein that is responsive to key features of disease pathology."

"Our findings clearly implicate clusterin, but there may well be other proteins in plasma related to the disease process, and indeed our previous studies and those of others suggest this is the case," they conclude. "These results may have wider implications for the identification of other amyloid chaperone proteins in plasma, both as putative Alzheimer's disease biomarkers as well as drug targets of disease-modifying treatments."


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Contact: Louise Pratt
louise.a.pratt@kcl.ac.uk
44-207-848-5378
JAMA and Archives Journals
Source:Eurekalert

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