Navigation Links
Plant researchers locate transporter used for nicotine metabolism
Date:11/1/2011

The next time you take aspirin for a headache, thank a willow tree. Salicylic acid, a compound chemically similar to aspirin, is found in willow tree bark and is made by the plant as a chemical defense against pathogens. By mimicking the chemical production processes of plants, scientists have been able to synthetically produce and engineer many important alkaloid drug products, including caffeine, atropine (an anti-spasmodic used to treat heart arrhythmia), nicotine, morphine and quinine.

The trick, however, is to understand how a plant produces these compounds and then transports them through the plant. A team of Virginia Tech and Purdue University scientists have identified a distinct transporter used by tobacco plant cells for nicotine metabolism. The research appears in the Oct. 17 online before print issue of the Proceedings of the National Academy of Sciences (PNAS) in the article, "A tobacco nicotine uptake permease effects alkaloid metabolism."

The transporter, called nicotine uptake permease (NUP1) allows alkaloids nitrogen-containing compounds to pass into plant cells. The transporter is a tubular structure found in the outer boundary of the plant cell, known as the plasma membrane. Passage of alkaloids from one cell to another in an assembly line fashion is crucial to the biosynthesis of many medicinal plant alkaloids. However, prior to the study, it was not known exactly how the alkaloids were able to move either in or out of the cell.

"We knew that the general process of going in and out is important for alkaloid metabolism, but we didn't know the details," said John Jelesko, associate professor of plant pathology, physiology, and weed science at Virginia Tech. "The NUP1 transporter is very specific for nicotine other closely related alkaloids don't use this transporter. That degree of specificity is rather unusual."

Identif
'/>"/>

Contact: Lindsay Key
ltkey@vt.edu
540-231-6594
Virginia Tech
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UK HealthCare surgeons are first to perform novel procedures prior to transplant
2. High-dose melphalan and autologous stem cell transplantation increases survival
3. Lab-made skin cells will aid transplantation, cancer, drug discovery research
4. Research finds gallium nitride is non-toxic, biocompatible - holds promise for implants
5. Heart transplant surgery safe and effective: A Canadian retrospective spanning 3 decades
6. Biomarker detects graft-versus-host-disease in cancer patients after bone marrow transplant
7. Successful pregnancy possible after kidney transplant
8. Public reporting hasnt improved transplant centers care
9. Study uncovers why anti-rejection drugs for transplant patients cause hypertension
10. Stem Cell Therapy Might Help Kidney Transplant Patients
11. Transforming medical implants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/5/2015)... Central Nebraska Imaging (CNI) is pleased to ... new logo and optimized website. , CNI’s ... to expert diagnostic imaging, centered on patient care. The ... be a resource for Nebraska patients and a tool ... and referral functionality, video content and resources to understand ...
(Date:3/5/2015)... March 05, 2015 HomeCEUConnection.com ... March with extra savings on their nutrition ... of health and nutrition, HomeCEUConnection.com is offering ... the promo code, NUTRITION2015 . , ... , HomeCEUConnection.com provides high-quality continuing education ...
(Date:3/5/2015)... On March 2, 2015, NBC News posted ... Rise, Plastic Surgeons Say,” that comments on the 2014 ... Plastic Surgery and the American Society of ... doubling of surgical butt augmentations performed in 2014. According ... this increase can be attributed to the social impact ...
(Date:3/5/2015)... In honor of National Drug Facts Week, ... and alcohol abuse in schools and communities across America, ... information on some of the dangers and statistics involved ... Institute on Drug Abuse, this annual promotion of the ... illusions that teens and young adults get from television, ...
(Date:3/5/2015)... MS (PRWEB) March 05, 2015 At ... Basics and Beyond,” leaders in addiction treatment met today ... updates in best clinical practices. Among the numerous respected ... , who will address the role that pain medications ... and new evidence-based treatment options. , "It is hard ...
Breaking Medicine News(10 mins):Health News:Central Nebraska Imaging Center Gets Rebranding 2Health News:HomeCEUConnection.com Offers Nutrition CEUs this March to Celebrate Nutrition Month 2Health News:The Kim Kardashian and Jennifer Lopez Effect: Butt Augmentations Double from 2013 to 2014 2Health News:A Forever Recovery Issues New Tips for Sobriety for National Drug Facts Week 2Health News:National Addiction Treatment Expert William S. “Bill” Jacobs, Md Speaks At Prestigious 7th Annual Mississippi Addiction Conference 2Health News:National Addiction Treatment Expert William S. “Bill” Jacobs, Md Speaks At Prestigious 7th Annual Mississippi Addiction Conference 3
... can learn much from each other in regard ... wrong-site surgeries, HARRISBURG, Pa., Jan. 10 ... decreased during 2007, some,facilities continue to report wrong-site ... protocols implemented by other Pennsylvania,facilities that have been ...
... Prepares to Release Alarming New HIV Rates; Governor ... 10 AIDS Healthcare,Foundation (AHF) today urged California ... of proposed budget cuts in AIDS services,that will ... for,Californians living with HIV/AIDS as he seeks to ...
... for "The Grove Circle," Honoring Planned Gift Donors,Reflects Shared ... - Andrew S. Grove,co-founder of technology giant Intel and ... Research, announced his intent to bequeath a,portion of his ... Fox Foundation.,Mr. Grove,s gift will establish The Grove Circle, ...
... can alter timetable , , THURSDAY, Jan. 10 (HealthDay News) -- ... a half years following their diagnosis, new British research shows. ... life expectancy, according to the report in the Jan. 11 ... Common socioeconomic influences, such as marital status, social class and ...
... January 9, 2008 In a study published ... from the University of Aberdeen report that the ... and praised as "the first and,only representative of ... fact similar,to other existing compounds, and is beneficial ...
... Animal study shows preconditioning cardiac cells helps organ better tolerate ... -- Just as daily runs can prepare you to survive ... spells could condition cardiac cells to better withstand the damage ... University of Cincinnati suggests. , Ultimately, if validated in humans, ...
Cached Medicine News:Health News:Patient Safety Authority Visits Facilities for Information on Wrong-Site Surgery 2Health News:Patient Safety Authority Visits Facilities for Information on Wrong-Site Surgery 3Health News:Patient Safety Authority Visits Facilities for Information on Wrong-Site Surgery 4Health News:AHF to Schwarzenegger: 'AIDS Cuts Are Deadly' 2Health News:AHF to Schwarzenegger: 'AIDS Cuts Are Deadly' 3Health News:Intel Co-Founder Andrew S. Grove Dedicates Portion of His Estate, Up to $40 Million, to Michael J. Fox Foundation 2Health News:Intel Co-Founder Andrew S. Grove Dedicates Portion of His Estate, Up to $40 Million, to Michael J. Fox Foundation 3Health News:Dementia Diagnosis Typically Means Death Within Five Years 2Health News:Memantine and Alzheimer's disease 2Health News:Memantine and Alzheimer's disease 3Health News:Priming Heart Before an Attack Could Limit Damage 2Health News:Priming Heart Before an Attack Could Limit Damage 3
(Date:3/5/2015)... March 5, 2015 Vermillion, Inc. (Nasdaq: ... focused on gynecologic disease, announced today it will ... the market open on Wednesday, March 25, 2015, ... at 8:30am Eastern. Conference Call & Webcast: ... Eastern/5:30am Pacific Domestic: , 800-753-9057International: , 913-981-5571Conference ID: ...
(Date:3/5/2015)... YORK , March 5, 2015  As ... set of regulations, Ethics & Compliance professionals are ... to a new survey issued today by LRN, ... and education. An overwhelming majority of respondents expressed ... the most important component of E&C training programs ...
(Date:3/5/2015)... -- Sanomedics, Inc. (OTC: SIMH, SIMHD) ("Sanomedics" or the "Company"), ... and acquiring cutting-edge technology, products and services announced today ... at booth # 709 at the National Association ... on March 11-13, 2015 at Caesars Palace in ... The 36 th annual NAPNAP Conference will bring ...
Breaking Medicine Technology:Vermillion to Report Fourth Quarter and Year-End 2014 Financial Results and Host an Investor Conference Call on March 25 2Pharmaceutical Ethics & Compliance Professionals Place Company Values Front and Center 2Pharmaceutical Ethics & Compliance Professionals Place Company Values Front and Center 3Sanomedics to Showcase the Caregiver at National Association of Pediatric Nurse Practitioners Conference 2Sanomedics to Showcase the Caregiver at National Association of Pediatric Nurse Practitioners Conference 3
... Cytotech Labs, a Boston based pharmaceutical company and ... Berg Biosystems and Berg Diagnostics today presented groundbreaking insight ... Otto Warburg.  The Warburg Hypothesis asserts that increased utilization ... by cancer cells in return for evasion of apoptosis, ...
... April 4, 2011 Breckenridge is announcing that it entered ... Salalah, Sultanate of Oman to market Neomycin Sulfate Tablets. Under ... by Oman Pharma, and marketed and distributed by Breckenridge on ... been approved by the U.S. Food and Drug Administration (FDA), ...
Cached Medicine Technology:Cytotech Labs Unravels Hallmark Insight Into Metabolic Control of Cancer, Presents Work at Major AACR Cancer Meeting 2Cytotech Labs Unravels Hallmark Insight Into Metabolic Control of Cancer, Presents Work at Major AACR Cancer Meeting 3Cytotech Labs Unravels Hallmark Insight Into Metabolic Control of Cancer, Presents Work at Major AACR Cancer Meeting 4
Blunt tlpped forceps wlth smooth jaws that have been diamond dusted for enhanced grasping. Excellent for grasping of immature membranes....
Blunt tipped forceps with entire interior surface of tip serrated. For general purpose membrane grasping (coarse membranes)....
Pic forceps design that is slightly curved; tips have special "surface treatment" for enhanced manipulation of the retina....
Blunt tipped forceps with very small grasping platforms on each tip. For grasping very fine membranes or grasping membranes adherent to the retinal surface....
Medicine Products: