Navigation Links
Plant flavonoid luteolin blocks cell signaling pathways in colon cancer cells
Date:1/22/2012

Plant flavonoid luteolin blocks cell signaling pathways in colon cancer cells

Luteolin is a flavonoid commonly found in fruit and vegetables. This compound has been shown in laboratory conditions to have anti-inflammatory, anti-oxidant and anti-cancer properties but results from epidemiological studies have been less certain. New research published in BioMed Central's open access journal BMC Gastroenterology shows that luteolin is able to inhibit the activity of cell signaling pathways (IGF and PI3K) important for the growth of cancer in colon cancer cells.

Colon cancer is the second most frequent cause of cancer-related death in the Western World. Colon cancer cells have elevated levels of IGF-II compared to normal colon tissues. It is thought that this is part of the mechanism driving uncontrolled cell division and cancer growth. Researchers from Korea showed that luteolin was able to block the secretion of IGF-II by colon cancer cells and within two hours decreased the amount of receptor (IGF-IR) precursor protein. Luteolin also reduced the amount of active receptor (measured by IGF-I dependent phosphorylation).

Luteolin inhibited the growth stimulatory effect of IGF-I and the team led by Prof Jung Han Yoon Park found that luteolin affected cell signaling pathways which are activated by IGF-I in cancer. Prof Jung Han Yoon Park explained, "Luteolin reduced IGF-I-dependent activation of the cell signaling pathways PI3K, Akt, and ERK1/2 and CDC25c. Blocking these pathways stops cancer cells from dividing and leads to cell death."

Prof Jung Park continued, "Our study, showing that luteolin interferes with cell signaling in colon cancer cells, is a step forward in understanding how this flavonoid works. A fuller understanding of the in vivo results is essential to determine how it might be developed into an effective chemopreventive agent."


'/>"/>
Contact: Dr Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Source:Eurekalert

Page: 1

Related medicine news :

1. Extracorporeal membrane oxygenation as a bridge to lung transplantation
2. U-M News: Kidney failure risk higher for liver transplant patients following policy change
3. FDA Warns of Painkiller Mix-Up at Nebraska Plant
4. U.S. Doctors Behind Face Transplants Give Details of Procedure
5. Autologous stem cell transplantation does not improve os in patients with follicular lymphoma
6. Missouri Botanical Garden scientists examine toxicity of medicinal plants in Peru
7. HIV drug reduces graft-versus-host disease in stem cell transplant patients, Penn study shows
8. NewYork-Presbyterian/Columbia surgeons perform first ex vivo lung transplants in New York
9. Bone marrow and blood stem cell transplant survival rates equal, when donor is unrelated to patient
10. Planting improves heart rate, stress levels of mentally challenged adults
11. Sewage treatment plants may contribute to antibiotic resistance problem
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... 2017 , ... Neil H. Greco Insurance Agency, a northern New Jersey firm ... is launching a charity drive to raise awareness of heart disease and promote habits ... America, and is responsible for 1 in every 4 deaths at the national level ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... detect, and eliminate cyber threats in real-time, today announced a strategic partnership with ... in Selangor, Malaysia. Joining other Seceon partners, TechLab Security has become a strategic ...
(Date:1/17/2017)... ... 17, 2017 , ... Many people make New Year’s resolutions or renew their commitment to better ... it easier for people who want to kick off 2017 with better smiles. Dr. Mondavi ... , These special offers include: , , A new patient package ...
(Date:1/16/2017)... (PRWEB) , ... January 17, 2017 , ... Recently, patients ... in Southwest Michigan, joined other volunteers and organizations in support of the annual Binder ... children and families dressed up in colorful costumes of all designs coming out to ...
(Date:1/16/2017)... ... January 16, 2017 , ... With the Grand Opening Event planned for February ... by sports teams and the general public. Built in five months by Centerpoint, the ... converted into basketball or pickleball courts. The space is also suitable for indoor soccer ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... NEW YORK , Jan. 17, 2017 ... Summary GlobalData,s new report, "EU5 Glucose Monitoring Market ... EU5 Glucose Monitoring market. The report provides value, in ... prices (USD) within market segments - Blood Glucose Meters, ... also provides company shares and distribution shares data for ...
(Date:1/17/2017)... , Jan. 17, 2017 The interventional ... billion by 2021 from USD 6.35 billion in 2016, ... driving the growth of this market are rising incidence ... for minimally invasive surgeries. The global interventional ... application, and region. On the basis of type, the ...
(Date:1/17/2017)... -- The Global Nebulizers Market is poised to grow ... decade to reach approximately $1698.68 million by 2025. Some ... include rapidly growing demand in emerging regions, increasing use ... and online marketing strategies by key players. ... pneumatic nebulizers, ultrasonic nebulizers and mesh nebulizers. Pneumatic nebulizers ...
Breaking Medicine Technology: