Navigation Links
Plant flavonoid luteolin blocks cell signaling pathways in colon cancer cells
Date:1/22/2012

Plant flavonoid luteolin blocks cell signaling pathways in colon cancer cells

Luteolin is a flavonoid commonly found in fruit and vegetables. This compound has been shown in laboratory conditions to have anti-inflammatory, anti-oxidant and anti-cancer properties but results from epidemiological studies have been less certain. New research published in BioMed Central's open access journal BMC Gastroenterology shows that luteolin is able to inhibit the activity of cell signaling pathways (IGF and PI3K) important for the growth of cancer in colon cancer cells.

Colon cancer is the second most frequent cause of cancer-related death in the Western World. Colon cancer cells have elevated levels of IGF-II compared to normal colon tissues. It is thought that this is part of the mechanism driving uncontrolled cell division and cancer growth. Researchers from Korea showed that luteolin was able to block the secretion of IGF-II by colon cancer cells and within two hours decreased the amount of receptor (IGF-IR) precursor protein. Luteolin also reduced the amount of active receptor (measured by IGF-I dependent phosphorylation).

Luteolin inhibited the growth stimulatory effect of IGF-I and the team led by Prof Jung Han Yoon Park found that luteolin affected cell signaling pathways which are activated by IGF-I in cancer. Prof Jung Han Yoon Park explained, "Luteolin reduced IGF-I-dependent activation of the cell signaling pathways PI3K, Akt, and ERK1/2 and CDC25c. Blocking these pathways stops cancer cells from dividing and leads to cell death."

Prof Jung Park continued, "Our study, showing that luteolin interferes with cell signaling in colon cancer cells, is a step forward in understanding how this flavonoid works. A fuller understanding of the in vivo results is essential to determine how it might be developed into an effective chemopreventive agent."


'/>"/>
Contact: Dr Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Source:Eurekalert

Page: 1

Related medicine news :

1. Extracorporeal membrane oxygenation as a bridge to lung transplantation
2. U-M News: Kidney failure risk higher for liver transplant patients following policy change
3. FDA Warns of Painkiller Mix-Up at Nebraska Plant
4. U.S. Doctors Behind Face Transplants Give Details of Procedure
5. Autologous stem cell transplantation does not improve os in patients with follicular lymphoma
6. Missouri Botanical Garden scientists examine toxicity of medicinal plants in Peru
7. HIV drug reduces graft-versus-host disease in stem cell transplant patients, Penn study shows
8. NewYork-Presbyterian/Columbia surgeons perform first ex vivo lung transplants in New York
9. Bone marrow and blood stem cell transplant survival rates equal, when donor is unrelated to patient
10. Planting improves heart rate, stress levels of mentally challenged adults
11. Sewage treatment plants may contribute to antibiotic resistance problem
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... (PRWEB) August 28, 2014 A St. ... Danis & Lowe reports that the C.R. Bard ... thousands of consolidated transvaginal mesh lawsuits, recently filed a ... #136 pertains to the pretrial discovery process, and more ... sensitive evidence. , Carey Danis & Lowe is a ...
(Date:8/27/2014)... (PRWEB) August 28, 2014 Recently, BambooIndustry.com, an ... items, has announced that new bamboo panels are ... now providing deep discounts for clients worldwide. All people that ... a discounted rate, from 10 to 30 percent off. ... the new panels. “At the moment, all our new and ...
(Date:8/27/2014)... West Palm Beach, Florida (PRWEB) August 28, 2014 ... star Kevin Harrington, Chairman of As Seen On ... also known as “The Millionaire Maker”. as Excelerate attendees ... real sharks, and will have the ability to pitch ... team of World Renowned Business Experts and Millionaire Mentors ...
(Date:8/27/2014)... (PRWEB) August 28, 2014 Delta, a ... recently added several practical Cat D7R Dozers to its ... company’s senior spokesman has announced that all these items ... this promotion is to expand Delta’s market share in ... proud to launch the special offer; he has much ...
(Date:8/27/2014)... August 27, 2014 Taking its popular obstacle ... Steele Creek YMCA will host its largest crowd at ... Saturday, September 13 at YMCA Camp Thunderbird . ... divisions: adult, youth and teams. Within each division, runners ... their physical limit - for a worthy cause. All ...
Breaking Medicine News(10 mins):Health News:Carey Danis & Lowe Reports On New Court Order in C.R. Bard Transvaginal Mesh MDL 2Health News:BambooIndustry.com: Cheap Bamboo Panels for Clients Worldwide Offered Online 2Health News:Reliable Supplier Delta Adds New Items To Its Used Bulldozer Collection 2Health News:C2 Survival Racers Go to Extremes to Provide Kids with YMCA Programs 2
... , , ... , ... , , , ... ...
... ... ... ... ...
... has studied the international research alliance the Multilateral Initiative ... general and the strengthening of research environments in Africa. ... in areas outside Africa. This has led to a ... problems that dominate everyday life in those areas where ...
... ... iTouch. The innovative torque application is the first of its kind. , ... San Diego, CA (PRWEB) February 22, 2010 -- Flexible Assembly ... iTouch. The innovative torque application is the first of its kind and is free for ...
... , ... Shield of Texas has designated Houston Northwest Medical Center as a Blue Distinction Center for ... Houston, TX ... Northwest Medical Center as a Blue Distinction Center for Spine Surgery. Blue Distinction Centers for ...
... ... ... ... ...
Cached Medicine News:Health News:Statewide Poll: Pennsylvania Must Adequately Fund Senior Care Services 2Health News:Statewide Poll: Pennsylvania Must Adequately Fund Senior Care Services 3Health News:Remuda Ranch Programs for Eating and Anxiety Disorders Sponsors a Special Edition of the Award-Winning Documentary America The Beautiful 2Health News:Remuda Ranch Programs for Eating and Anxiety Disorders Sponsors a Special Edition of the Award-Winning Documentary America The Beautiful 3Health News:Remuda Ranch Programs for Eating and Anxiety Disorders Sponsors a Special Edition of the Award-Winning Documentary America The Beautiful 4Health News:Remuda Ranch Programs for Eating and Anxiety Disorders Sponsors a Special Edition of the Award-Winning Documentary America The Beautiful 5Health News:Malaria research must be based in Africa 2Health News:Flexible Assembly Systems Announces New Torque Calculator App for the iPhone 2Health News:Houston Northwest Medical Center Has Been Designated as a Blue Distinction Center for Spine Surgery 2Health News:Houston Northwest Medical Center Has Been Designated as a Blue Distinction Center for Spine Surgery 3Health News:Houston Northwest Medical Center Has Been Designated as a Blue Distinction Center for Spine Surgery 4Health News:AppDynamics Announces General Availability of AppDynamics v2.0 2Health News:AppDynamics Announces General Availability of AppDynamics v2.0 3Health News:AppDynamics Announces General Availability of AppDynamics v2.0 4Health News:AppDynamics Announces General Availability of AppDynamics v2.0 5Health News:AppDynamics Announces General Availability of AppDynamics v2.0 6Health News:AppDynamics Announces General Availability of AppDynamics v2.0 7Health News:AppDynamics Announces General Availability of AppDynamics v2.0 8Health News:AppDynamics Announces General Availability of AppDynamics v2.0 9
(Date:8/27/2014)... , Aug. 27, 2014 An experimental drug designed ... a viable first treatment for anemia of inflammation, according to ... treatment published online today in Blood , ... (ASH).    Anemia is a condition that occurs ... not function properly. When an individual has anemia, the body ...
(Date:8/27/2014)... 27, 2014 Kewaunee Scientific Corporation (Nasdaq: ... increased its quarterly cash dividend by 9% to twelve ... share, beginning with the dividend payable on September 22, ... business on September 8, 2014. About ... Kewaunee Scientific Corporation is a recognized global leader in ...
(Date:8/27/2014)... and NINGBO, China , Aug. ... Ningbo Menovo Pharmaceutical Co., Ltd, ("Menovo") today announced they ... of generic pharmaceuticals, primarily targeting the United ... agreement, Amerigen and Menovo will jointly develop products for ... . Menovo will be responsible for manufacturing API ...
Breaking Medicine Technology:Drug Represents First Potential Treatment for Common Anemia 2Drug Represents First Potential Treatment for Common Anemia 3Amerigen Pharmaceuticals Limited and the Ningbo Menovo Pharmaceutical Co., Ltd, today announced they had entered into a collaboration agreement regarding the development of generic pharmaceuticals, primarily targeting the United States market 2
... announces that a new market research report is ... Test-Volume-Sales-Forecasts-and-Supplier-Shares-by-Country.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic title=,The 2011 Prostatic Acid Phosphatase Testing Market: ... Test Volume, Sales Forecasts and Supplier Shares ... US, Europe, Japan ...
... /PRNewswire-Asia-FirstCall/ -- Dehaier Medical Systems Ltd. (Nasdaq: ... emerging leader in the development, assembly, marketing and sale ... today announced its financial results for the third quarter ... Third Quarter 2011 Financial Highlights   ...
Cached Medicine Technology:The 2011 Prostatic Acid Phosphatase Testing Market: US, Europe, Japan 2The 2011 Prostatic Acid Phosphatase Testing Market: US, Europe, Japan 3The 2011 Prostatic Acid Phosphatase Testing Market: US, Europe, Japan 4The 2011 Prostatic Acid Phosphatase Testing Market: US, Europe, Japan 5Dehaier Medical Announces Record Third Quarter 2011 Financial Results 2Dehaier Medical Announces Record Third Quarter 2011 Financial Results 3Dehaier Medical Announces Record Third Quarter 2011 Financial Results 4Dehaier Medical Announces Record Third Quarter 2011 Financial Results 5Dehaier Medical Announces Record Third Quarter 2011 Financial Results 6Dehaier Medical Announces Record Third Quarter 2011 Financial Results 7Dehaier Medical Announces Record Third Quarter 2011 Financial Results 8Dehaier Medical Announces Record Third Quarter 2011 Financial Results 9Dehaier Medical Announces Record Third Quarter 2011 Financial Results 10
... MaximEyes by First Insight is the ... records solution for eye care professionals. ... with Eyefinitys online servicesrequest VSP authorizations, ... MaximEyes offers EMR, scheduling, billing, demographics, ...
... software- RLISYS provides a ... Support, and Training exclusively ... Ophthalmology, and Opticianry- The ... allowing you to focus ...
... The Advia 120 hematology ... streamline laboratory workflow and ... This analyzer offers a ... assays, meeting the needs ...
The K-4500 automated hematology analyzer offers fast reliable test results of 18-parameter plus 3-histograms, valuable for effective diagnosis....
Medicine Products: