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Plankton inspires creation of stealth armor for slow-release microscopic drug vehicles
Date:1/31/2011

The ability of some forms of plankton and bacteria to build an extra natural layer of nanoparticle-like armour has inspired chemists at the University of Warwick to devise a startlingly simple way to give drug bearing polymer vesicles (microscopic polymer based sacs of liquid) their own armoured protection.

The Warwick researchers have been able to decorate these hollow structures with a variety of nanoparticles opening a new strategy in the design of vehicles for drug release, for example by giving the vesicle "stealth" capabilities which can avoid the body's defences while releasing the drug.

Advances in polymerisation have led to a surge in the creation of vesicles made from polymer molecules. Such vesicles have interesting chemical and physical properties which makes these hollow structures potential drug delivery vehicles.

The University of Warwick team were convinced that even more strength, and interesting tailored properties, could be given to the vesicles if they could add an additional layer of colloidal armour made from a variety of nanoparticles.

Lead researcher on the University of Warwick team Associate Professor Stefan Bon said:

"We took our inspiration from nature, in how it adds protection and mechanical strength in certain classes of cells and organisms. In addition to the mechanical strength provided by the cytoskeleton of the cell, plants, fungi, and certain bacteria have an additional cell wall as outermost boundary. Organisms that particularly attracted our interest were those with a cell wall composed of an armour of colloidal objects for instance bacteria coated with S-layer proteins, or phytoplankton, such as the coccolithophorids, which have their own CaCO3-based nano-patterned colloidal armour"

The Warwick researchers hit on a surprisingly simple and highly effective method of adding a range of different types of additional armour to the polymer based vesicles. One of those arm
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Contact: Dr.Stefan A. F. Bon
S.bon@warwick.ac.uk
44-247-657-4009
University of Warwick
Source:Eurekalert  

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