Navigation Links
Pituitary hormone TSH found to directly influence bone growth
Date:9/13/2011

Researchers at Mount Sinai School of Medicine have found that thyroid-stimulating hormone (TSH), a hormone produced in the anterior pituitary gland that regulates endocrine function in the thyroid gland, can promote bone growth independent of its usual thyroid functions. The research suggests that TSH, or drugs that mimic its affect on bone, may be key to possible future treatments for osteoporosis and other conditions involving bone loss, such as cancer. The findings were published online this week in the National Academy of Sciences journal PNAS.

The same Mount Sinai researchers had previously published research showing that TSH inhibits the creation of osteoclasts, a type of cell that removes bone tissue from the body. With this new study, however, the researchers have established for the first time that TSH also activates osteoblasts, which are cells responsible for bone formation.

"There are relatively few treatments right now for osteoporosis, and virtually all of them focus on limiting osteoclasts that is, fighting the loss of existing bone," said Terry F. Davies, MD, FRCP, FACE, Florence and Theodore Baumritter Professor of Medicine, Mount Sinai School of Medicine. "However, our study shows that future progress in osteoporosis therapies may hinge on medications that can mimic the effects of TSH and promote the growth of new bone. The key will be to develop TSH analogs that would activate osteoblasts and yet not affect the thyroid gland the way TSH itself does."

"Osteoporosis is really an imbalance in the functions that create and destroy bone in the body," said Mone Zaidi, MD, PhD, FRCP, FACE, Hon MD, Professor of Medicine, and Director of the Mount Sinai Bone Program, Mount Sinai School of Medicine. "Our findings indicate that there may be a novel new method for addressing the lack of bone production. Our discovery that TSH causes bone growth also represents a new way of thinking about the role of certain glands and how
'/>"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Experts issue recommendations for evaluating and treating pituitary incidentalomas
2. FSU study takes novel approach to understanding pituitary function
3. Sex hormones impact career choices
4. Some Older Breast Cancer Patients Can Skip Hormone Therapy: Study
5. Smoking after menopause may increase sex hormone levels
6. Decline in Hormone Therapy Linked to Fewer Mammograms
7. Drop in hormone therapy use linked with drop in mammogram rates
8. Hormone reduces risk of heart failure from chemotherapy
9. Yoga boosts stress-busting hormone, reduces pain: York U study
10. Hormone therapy may be hazardous for men with heart conditions
11. Effects of exercise on meal-related gut hormone signals
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 22, 2015 The Incredible Bulk is a ... to increase lean muscle by up to 30lbs in less ... attention of HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. , ... a step-by-step, scientific diet formula that allows the body to ...
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota ... it means to “Live Fearless.” , The “Faces ... their stories about how they or someone they know has ... living in the moment. By telling these types of stories ...
(Date:1/22/2015)... The federal court overseeing thousands of vaginal mesh ... District of West Virginia has upheld a $2 million verdict ... trial. In an Order dated January 21st, the Court denied ... C.R. Bard had not proven a miscarriage of justice. (Cisson ...
(Date:1/22/2015)... 22, 2015 A new white paper ... and person-centeredness in the long-term care environment as well ... the continuum. The paper, “The Power of Person-Centeredness in ... and practices of the patient, resident and family experience ...
(Date:1/22/2015)... 2015 Autocarinsurancebest.com has released a new blog ... auto insurance policy . , Auto insurance quotes help ... is no longer necessary to call an agent or visit ... online on a single website: http://autocarinsurancebest.com/ . , Every ...
Breaking Medicine News(10 mins):Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 2Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 3Health News:Court Upholds $2 Million Vaginal Mesh Lawsuit Verdict Levied Against C.R. Bard in First Federal Bellwether Trial, Bernstein Liebhard LLP Reports 4Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3Health News:Commercial Auto Insurance Provides Several Important Features! 2
... Kurtz Resigns as President and Chief Executive Officer; Evelyn ... Appointed Acting Chief Executive Officer -, LA JOLLA, Calif., ... announced that Neil Kurtz, M.D., is,resigning as President, Chief Executive ... 31, 2008. Dr. Kurtz is leaving TorreyPines,to assume the role ...
... a San Diego biotech company, developed the first method to ... iron and its distribution in the body. This ... millions of people worldwide such as anemias and iron overload ... the amount of hepcidin in the blood. When levels ...
... Patients and Helps ... Money for Make-A-Wish Foundation, PITTSBURGH, Aug. 8 Aethon ... robot to children,s,hospitals across the country. Also, Aethon will make ... that is deployed. The JR,TUG was initially introduced at the ...
... surgery, pair of studies finds , , FRIDAY, Aug. 8 (HealthDay ... not be accurate for obese men, leaving them more vulnerable ... effective for them, a new pair of studies found. , ... aggressive form of the disease," said Dr. Stephen Freedland, an ...
... Cervical Cancer Screening Participants Receive $15 ... ... Aug. 8 Keystone Mercy Health Plan, the,largest medical assistance ... Inc. (DVCH), a,non-profit organization that provides community-based, primary medical,dental and ...
... the Harvard School of Public Health, today expressed "deep ... Kamiar Alaei, a 2007 Masters of Science graduate of ... The brothers are Iranian physicians working on the prevention ... in their country." , , "There is concern for their ...
Cached Medicine News:Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 2Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 3Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 4Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 5Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 6Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 7Health News:Charlotte Children's Hospital Gets a Delivery from Aethon's Train-Themed Robot This Fall 2Health News:Charlotte Children's Hospital Gets a Delivery from Aethon's Train-Themed Robot This Fall 3Health News:Obese Men Face Twin Threat From Prostate Cancer 2Health News:Keystone Mercy and DVCH to Offer Screenings for National Health Center Week 2
(Date:1/23/2015)... ANGELES , Jan. 23, 2015 A lot of ... best methods for treating  certain illnesses, injuries, or conditions. As ... replace previous treatment methods with ones that they consider to ... hernias, there is not one textbook method of treatment that ...
(Date:1/23/2015)... WYNNEWOOD, Pa. , Jan. 23, 2015  MedScope ( ... has been nominated for a 2015 Connected World ... Personal Emergency Response System (mPERS), that can be used ... M2M technology partner.  In nominating MedScope, ...
(Date:1/23/2015)...  HyGreen, Inc., a leader in hand hygiene monitoring, today ... a subsidiary of Ascendis Health Limited, in ... hundreds of millions of patients around the world are ... from patient to patient via the unwashed hands of ...
Breaking Medicine Technology:No One-Size-Fits-All Remedy for Hernia Correction 2MedScope Nominated by RacoWireless for Prestigious 2015 Connected World Magazine Connected World Award 2HyGreen Partners with RCA Medical in Johannesburg, South Africa 2
CMF OL1000 Bone Growth Stimulators are portable, battery-powered medical devices indicated for use in the noninvasive treatment of an established nonunion fracture acquired secondary to trauma, exclu...
... the surgical versatility you demand when treating ... EBI OsteoGen-D offers 40 microamperes of direct ... with 20 microamperes. Available in both Mesh ... flexibility with any of your bone graft ...
... area contact between grant material and fracture ... long bones., ,Grid-Like Format of Mesh Cathode ... Bone , ,The innovative Mesh Cathode of ... area and a scaffolding effect designed to ...
Flowmate makes portable uroflowmetry easy, accurate and dignified. Flowmate has automatic start and stop as well as simple and straightforward reporting from its own printer....
Medicine Products: