Navigation Links
Pitt scientists find intrinsic changes in protein shape influence drug binding
Date:8/19/2009

PITTSBURGH, Aug. 19 Computational biologists at the University of Pittsburgh School of Medicine have shown that proteins have an intrinsic ability to change shape, and this is required for their biological activity. This shape-changing also allows the small molecules that are attracted to a given protein to select the structure that permits the best binding. That premise could help in drug discovery and in designing compounds that will have the most impact on protein function to better treat a host of diseases.

The findings were published this week in the online version of the Proceedings of the National Academy of Sciences.

According to the classical view, known as "induced fit," drug binding causes a change in the target protein structure, explained senior author Ivet Bahar, Ph.D., professor and John K. Vries Chair of the Department of Computational Biology, Pitt School of Medicine. But it now appears that a protein has many different conformations that are already available even without the presence of a binding molecule, which is called the ligand. The ligand attaches to the protein shape that allows it to fit well, and that close interaction can lead to effective inhibition of protein function.

Gathering information about the array of conformations a target protein might exhibit can be of great use when designing new drugs, Dr. Bahar said. That allows the scientist to better identify the structural pocket into which the drug must fit to cause significant alterations in protein function, such as the inhibition of an enzyme reaction.

For the study, Dr. Bahar and her doctoral student, Ahmet Bakan, focused on three common drug targets, namely enzymes important in HIV, inflammatory response and the cell division cycle. Using the sets of conformations of protein-ligand complexes stored in the Protein Data Bank, an information repository for the scientific community at Rutgers University, the researchers figured out w
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... (PRWEB) April 21, 2015 AvePoint, ... platforms and devices, today announced a new enhancement to ... the new Microsoft Office 365 Management Activity API. This ... to fully audit and take action on all events ... “The new Office 365 Management Activity API provides customers ...
(Date:4/21/2015)... released a new blog post explaining how to find ... are large vehicles that fare well in crash tests. A ... car shows that passengers from the first car have a ... but these large vehicles may be unstable and they may ... possible to find low cost car insurance plans on a ...
(Date:4/21/2015)... 21, 2015 Carinsurancehints.com has released a ... explaining their impact on auto insurance prices . ... auto insurance prices. Clients should review their insurance options ... be bought under several forms. Some of the popular ... rivers can compare online rates and find the best ...
(Date:4/21/2015)... 2015 Respected academic institution selects Visage ... , Visage Imaging Inc. (“Visage”), a wholly owned subsidiary ... a seven-year contract with University of Florida Health — ... The deal furthers the penetration of Visage 7 ... area of the North American enterprise imaging market. ...
(Date:4/21/2015)... Now in its fifteenth year, ... to unite over 3,000 senior attendees from across ... Suburban Collection Showplace on June 3 and 4. ... Ford, and Kia are set to deliver headline ... is reshaping automotive as connectivity paves the way ...
Breaking Medicine News(10 mins):Health News:AvePoint Integrates Microsoft Office 365 Management Activity API into DocAve Policy Enforcer for Proactive SharePoint Monitoring 2Health News:AvePoint Integrates Microsoft Office 365 Management Activity API into DocAve Policy Enforcer for Proactive SharePoint Monitoring 3Health News:Auto Insurance Quotes For SUVs Are Available Online 2Health News:Heavily Circulated Roads Can increase Auto Insurance Costs 2Health News:Visage Imaging Signs University of Florida Health 2Health News:Visage Imaging Signs University of Florida Health 3Health News:Visage Imaging Signs University of Florida Health 4Health News:TU-Automotive Detroit 2015 Sample Attendee List Released 2Health News:TU-Automotive Detroit 2015 Sample Attendee List Released 3
... 2006 issue of the Journal of Adolescent Health by researchers// ... Miriam Hospital and Brown Medical School, suggests that as teens ... and increase their fast food consumption - both behaviors leads ... the transition from adolescence to adulthood appears to be a ...
... poultry farm in south western Japan in Kiyotake, around 750 ... ,This has been reported to the agricultural ministry ... out latest by Friday evening. If bird flu is confirmed, ... ,The farm in question has around 12000 ...
... to toddlers, parents need to be cautious as it may bring ... ,The Centre for Disease Control and Prevention in the US has ... children suffering from cold or cough without consulting their doctor. ... the age group of six months in 2005 revealed that they ...
... whose health and normal life was affected by a parrot was ... of Derbyshire who used to work for a pet shop had ... were very much like ordinary fever. But subsequent diagnosis revealed that ... he did not have direct contact with the sick African Grey ...
... the students gathered for a live chat with Indian American ... as she spoke from her zero-gravity// home among the stars, ... fact they had only read about in books before. ... and speak with three astronauts at the same platform - ...
... of data has revealed that more number of Canadians are ... decade ago. The recovery time for patients after// surgery is ... study of hospitalization and surgery rates undertaken by the Canadian ... patients in the healthcare system. The report showed that the ...
Cached Medicine News:Health News:Skipping Breakfast and Fast Food Consumption - Leads to Weight Gain 2Health News:Skipping Breakfast and Fast Food Consumption - Leads to Weight Gain 3Health News:Indian Students Thrilled to Talk to Sunita Williams 2
(Date:4/21/2015)... , April 21, 2015 ... are expected to grow at a rapid pace over ... vendors that provide technology services for indoor/outdoor cultivators and ... today are: Surna Inc. (OTC: SRNA), Totally Hemp Crazy ... E-Cigs Corp. (OTC: BVAP), 22 nd Century Group, ...
(Date:4/21/2015)... , April 21, 2015  Decision Diagnostics ... administrator and the exclusive worldwide sales, service and ... the FDA-cleared Green Alternative Strip, specifically designed to ... LifeScan OneTouch Ultra family of glucose testing meters, ... announced today that Johnson & Johnson/Lifescan has requested ...
(Date:4/21/2015)... April 21, 2015  Navitas has launched Aviator, a ... range of offerings for life sciences clients. Aviator supports ... platform enabling seamless flow of data across all applications ... launch, Navitas worked closely with Oracle to provide Argus, ... CTMS in the Cloud. ...
Breaking Medicine Technology:New Technology, Innovative Products & State-of-the-Art Equipment in the Legal Cannabidiol Industries Continue to Provide Growing Revenue Opportunities 2New Technology, Innovative Products & State-of-the-Art Equipment in the Legal Cannabidiol Industries Continue to Provide Growing Revenue Opportunities 3New Technology, Innovative Products & State-of-the-Art Equipment in the Legal Cannabidiol Industries Continue to Provide Growing Revenue Opportunities 4New Technology, Innovative Products & State-of-the-Art Equipment in the Legal Cannabidiol Industries Continue to Provide Growing Revenue Opportunities 5New Technology, Innovative Products & State-of-the-Art Equipment in the Legal Cannabidiol Industries Continue to Provide Growing Revenue Opportunities 6New Technology, Innovative Products & State-of-the-Art Equipment in the Legal Cannabidiol Industries Continue to Provide Growing Revenue Opportunities 7Decision Diagnostics Shrugs Off New Attack As Johnson & Johnson Panics In Patent Case 2Decision Diagnostics Shrugs Off New Attack As Johnson & Johnson Panics In Patent Case 3Navitas Launches Aviator - Cloud Based Platforms for Oracle Solutions 2Navitas Launches Aviator - Cloud Based Platforms for Oracle Solutions 3Navitas Launches Aviator - Cloud Based Platforms for Oracle Solutions 4
... 17 Engineer/pilot/attorney Jon Roberts, PhD, has dozens of ... thwarts piracy in movie theatres, gadgets that track important ... and even an electronic matchmaker that alerts two nearby ... their match. Now, as Chairman and VP R&D ...
... , , WALTHAM, Mass., Nov. 17 ... firms for pharmaceutical and healthcare issues, finds that, driven by ... novel fast acting opioid reformulations, the cancer pain drug market ... in 2018 in the United States, France, Germany, Italy, Spain, ...
Cached Medicine Technology:When Viruses (Including H1N1) and Bacteria are as Close as your Fingertips; VirWall's New Innovation Can Disarm Killer Keyboards 2The Cancer Pain Drug Market, Driven by the Continued Dominance of Opioids, Will Increase From $2.3 Billion in 2008 to $3.7 Billion in 2018 2
The upper body blanket is typically used for abdominal or lower body procedures. The upper body blankets warms the upper torso and arms. A clear drape is included to cover and warm the intubated pati...
Soft yet durable, these single-patient use pads are designed to have the quality look of reusable pads but provide the hygienic advantages of disposability....
This product is for the lower body and uses a Convective Warming System which is both soft and comfortable. Constructed of 2-ply material consisting of polyethylene film inner layer and non-woven out...
The torso blanket is designed to affix to the lower abdominal area and cover the upper half of the body....
Medicine Products: