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Pitt researchers build a better mouse model to study depression
Date:5/18/2011

roles in normal brain functioning. Mice have a CREB1 gene that is very similar to the human version and, with the aid of genetic engineering techniques, the researchers were able to establish a mutant mouse strain that bore the same genetic error. Since the control regions of corresponding human and mouse genes often have regions of high similarity, the methods described in this report may be useful in creating mouse models of other human diseases.

"Treatments that are the most effective and produce the fewest side effects typically address the root causes of the disease," Dr. Zubenko noted. "Animal models that recapitulate those root causes should better inform us about the brain mechanisms that lead to MDD, and have the best chance of leading to advances in treatment and prevention."


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Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

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