Navigation Links
Pitt researcher to co-direct national consortium on facial birth defects
Date:11/17/2009

PITTSBURGH, Nov. 17 Researchers at the University of Pittsburgh and the University of Iowa will lead a $9 million, five-year initiative to study the cause of facial birth defects. The FaceBase Consortium will create an encyclopedic database of how the faces of children develop and what goes wrong to cause malformations.

FaceBase will build a list of the genes and proteins that drive embryonic cell differentiation around the forming mouth. These cells become bone, cartilage, ligament, nerve and soft tissue, which are visible as the developing face in the first sonogram of a fetus. However, questions remain about how this development occurs.

"FaceBase will bring together data that's never before been in the same location," said Mary Marazita, Ph.D., co-principal investigator of the FaceBase Management and Coordination Hub and director of the Center for Craniofacial and Dental Genetics at the University of Pittsburgh School of Dental Medicine. "The hope is that this database will help us to piece together the information needed to intervene when facial development starts to go wrong or prevent it from going wrong in the first place."

Dr. Marazita and colleague, Seth Weinberg, Ph.D., research assistant professor at the Pitt School of Dental Medicine, also have received one of 10 independent FaceBase research and technology grants. This $1.5 million, five-year research grant will focus on acquiring 3D facial images and a large number of genetic markers from participants in Pittsburgh, Seattle and Houston. The resulting data will be available through FaceBase and will allow discovery of genes related to facial features.

Jeff Murray, M.D., professor, University of Iowa Carver College of Medicine, will serve as co-principal investigator of the FaceBase Management and Coordination Hub at the University of Iowa.

"It's an exciting challenge to help produce a database that brings together biochemical, molecular, genetic and imaging findings related to human facial and skull development," Dr. Murray said. "FaceBase will essentially create a 'how-to' manual of all the instructions that are needed to properly develop the mid-face, which includes the nose, upper lip and palate, or roof of the mouth."

Development of the FaceBase portal and database will be in collaboration with co-investigator Michael Becich, M.D., Ph.D., chairman of the Pitt Department of Biomedical Informatics. A prototype is expected to be ready within the next year followed by a fully functioning portal and database soon thereafter. FaceBase will be free and publicly accessible to the scientific community.


'/>"/>

Contact: Kristin Beaver
BeaverKC@upmc.edu
412-647-9966
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. Bipolar disorder relapses halved by Melbourne researchers
6. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
7. High and mighty: first common height gene identified by researchers behind obesity gene finding
8. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
9. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
10. Researchers develop long-lasting growth hormone
11. UVa researcher awarded $3.6 million grant to fight drug-resistant bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her son ... lash out at his family verbally and physically. , “When something upset him, he couldn’t ... would use it. He would throw rocks at my other children and say he was ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... ... is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are ... Code Talker Award, an essay contest in which patients and their families pay tribute ... presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative Solutions ... initiated cultivation and processing operations at its production facility, and opened its first ... is the manufacturer of a complete system of proactive air and surface purification ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Venture ... Golf Classic Tournament held on June 20th at the Woodmont Country Club at ... Luke’s Wings, an organization dedicated to helping service members that have been wounded in ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ., ... developing innovative inhaled drugs, announced today that it was ... Investments reconstituted its comprehensive set of U.S. and ... "This is an important milestone for Pulmatrix," said Chief ... shareholder awareness of our progress in developing drugs for ...
(Date:6/24/2016)... KNOXVILLE, Tenn. , June 24, 2016 /PRNewswire/ ... market providing less invasive and more durable cerebrospinal ... million in funding.  The Series-A funding is led ... the Lighthouse Fund, and other private investors.  Arkis, ... less-invasive neurosurgical instrumentation and the market release of ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Dialysis Devices Global Market - Forecast to 2022" report ... is the treatment method for the patients with kidney failure, ... and excess fluid from the patient,s blood and thus the ... sodium, potassium and chloride in balance. Increasing ...
Breaking Medicine Technology: