Navigation Links
Pitt researcher to co-direct national consortium on facial birth defects
Date:11/17/2009

PITTSBURGH, Nov. 17 Researchers at the University of Pittsburgh and the University of Iowa will lead a $9 million, five-year initiative to study the cause of facial birth defects. The FaceBase Consortium will create an encyclopedic database of how the faces of children develop and what goes wrong to cause malformations.

FaceBase will build a list of the genes and proteins that drive embryonic cell differentiation around the forming mouth. These cells become bone, cartilage, ligament, nerve and soft tissue, which are visible as the developing face in the first sonogram of a fetus. However, questions remain about how this development occurs.

"FaceBase will bring together data that's never before been in the same location," said Mary Marazita, Ph.D., co-principal investigator of the FaceBase Management and Coordination Hub and director of the Center for Craniofacial and Dental Genetics at the University of Pittsburgh School of Dental Medicine. "The hope is that this database will help us to piece together the information needed to intervene when facial development starts to go wrong or prevent it from going wrong in the first place."

Dr. Marazita and colleague, Seth Weinberg, Ph.D., research assistant professor at the Pitt School of Dental Medicine, also have received one of 10 independent FaceBase research and technology grants. This $1.5 million, five-year research grant will focus on acquiring 3D facial images and a large number of genetic markers from participants in Pittsburgh, Seattle and Houston. The resulting data will be available through FaceBase and will allow discovery of genes related to facial features.

Jeff Murray, M.D., professor, University of Iowa Carver College of Medicine, will serve as co-principal investigator of the FaceBase Management and Coordination Hub at the University of Iowa.

"It's an exciting challenge to help produce a database that brings together biochemical, molecular, genetic and imaging findings related to human facial and skull development," Dr. Murray said. "FaceBase will essentially create a 'how-to' manual of all the instructions that are needed to properly develop the mid-face, which includes the nose, upper lip and palate, or roof of the mouth."

Development of the FaceBase portal and database will be in collaboration with co-investigator Michael Becich, M.D., Ph.D., chairman of the Pitt Department of Biomedical Informatics. A prototype is expected to be ready within the next year followed by a fully functioning portal and database soon thereafter. FaceBase will be free and publicly accessible to the scientific community.


'/>"/>

Contact: Kristin Beaver
BeaverKC@upmc.edu
412-647-9966
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. Bipolar disorder relapses halved by Melbourne researchers
6. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
7. High and mighty: first common height gene identified by researchers behind obesity gene finding
8. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
9. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
10. Researchers develop long-lasting growth hormone
11. UVa researcher awarded $3.6 million grant to fight drug-resistant bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... (PRWEB) , ... January 23, 2017 , ... ... for Assisted Living (IHCA/INCAL), will serve as a healthcare industry expert at the ... The panel discussion, moderated by Inside Indiana Business host Gerry Dick, will feature ...
(Date:1/23/2017)... ... 2017 , ... "ProRandom is a set of camera tools that allow video editors to integrate ... Pro X," said Christina Austin - CEO of Pixel Film Studios. , With ProRandom, ... video footage. ProRandom works by using a virtual camera to create the illusion of ...
(Date:1/23/2017)... ... January 23, 2017 , ... “The Inn at the Mill”: a story of love and ... quest to become happy and content. , “The Inn at the Mill” is the ... in Germany and Vermont and is now living in Berks County on Crow Hill. ...
(Date:1/23/2017)... ... January 23, 2017 , ... “Some Infallible Characteristics of ... Father. “Some Infallible Characteristics of Christ” is the creation of published author, Rev. Dr. ... Baptist Church for thirteen years, a preacher for over nineteen, a pastor for over ...
(Date:1/22/2017)... ... 2017 , ... "Photo Cloud allows FCPX users to add favorited photos to ... ease," said Christina Austin - CEO of Pixel Film Studios. , To begin, ... timeline. Presets include scenes with one, three, four or five focus points. There are ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... -- The American Pharmacists Association (APhA) is excited about ... Underserved Areas Enhancement Act (H.R. 592) in ... previously introduced in the 114 th session of ... pharmacists and their patient care services. Sponsors ... (R-KY), G.K. Butterfield (D-NC), Tom Reed ...
(Date:1/23/2017)... Ahead of today,s trading session, Stock-Callers.com draws investors, attention ... the close: Kite Pharma Inc. (NASDAQ: KITE ), BioPharmX ... Regeneron Pharmaceuticals Inc. (NASDAQ: REGN ). According to a ... January 20 th , 2017, down on the day by about ... now at: ...
(Date:1/23/2017)... WELLESLEY, Massachusetts , January 23, 2017 Longer ... solid growth in the global market for medical device technologies. BCC ... particularly in the Asia-Pacific region, should see strong ... coverage, and rising disposable incomes. Continue Reading ... ...
Breaking Medicine Technology: