Navigation Links
Pitt researcher to co-direct national consortium on facial birth defects

PITTSBURGH, Nov. 17 Researchers at the University of Pittsburgh and the University of Iowa will lead a $9 million, five-year initiative to study the cause of facial birth defects. The FaceBase Consortium will create an encyclopedic database of how the faces of children develop and what goes wrong to cause malformations.

FaceBase will build a list of the genes and proteins that drive embryonic cell differentiation around the forming mouth. These cells become bone, cartilage, ligament, nerve and soft tissue, which are visible as the developing face in the first sonogram of a fetus. However, questions remain about how this development occurs.

"FaceBase will bring together data that's never before been in the same location," said Mary Marazita, Ph.D., co-principal investigator of the FaceBase Management and Coordination Hub and director of the Center for Craniofacial and Dental Genetics at the University of Pittsburgh School of Dental Medicine. "The hope is that this database will help us to piece together the information needed to intervene when facial development starts to go wrong or prevent it from going wrong in the first place."

Dr. Marazita and colleague, Seth Weinberg, Ph.D., research assistant professor at the Pitt School of Dental Medicine, also have received one of 10 independent FaceBase research and technology grants. This $1.5 million, five-year research grant will focus on acquiring 3D facial images and a large number of genetic markers from participants in Pittsburgh, Seattle and Houston. The resulting data will be available through FaceBase and will allow discovery of genes related to facial features.

Jeff Murray, M.D., professor, University of Iowa Carver College of Medicine, will serve as co-principal investigator of the FaceBase Management and Coordination Hub at the University of Iowa.

"It's an exciting challenge to help produce a database that brings together biochemical, molecular, genetic and imaging findings related to human facial and skull development," Dr. Murray said. "FaceBase will essentially create a 'how-to' manual of all the instructions that are needed to properly develop the mid-face, which includes the nose, upper lip and palate, or roof of the mouth."

Development of the FaceBase portal and database will be in collaboration with co-investigator Michael Becich, M.D., Ph.D., chairman of the Pitt Department of Biomedical Informatics. A prototype is expected to be ready within the next year followed by a fully functioning portal and database soon thereafter. FaceBase will be free and publicly accessible to the scientific community.


Contact: Kristin Beaver
University of Pittsburgh Schools of the Health Sciences

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. Bipolar disorder relapses halved by Melbourne researchers
6. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
7. High and mighty: first common height gene identified by researchers behind obesity gene finding
8. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
9. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
10. Researchers develop long-lasting growth hormone
11. UVa researcher awarded $3.6 million grant to fight drug-resistant bacteria
Post Your Comments:
(Date:11/26/2015)... ... November 26, 2015 , ... PRMA Plastic Surgery is updating their ... surgeons performed their 6,000th free flap breast reconstruction surgery! , “What an accomplishment for ... excited to rebuild lives and it’s an honor to have served all of these ...
(Date:11/26/2015)... ... November 26, 2015 , ... Pixel ... self-animating trailer titles with ProTrailer: Vintage. This newly styled ProTrailer pack comes with ... work with any font, giving users limitless opportunities to stylize and create designs ...
(Date:11/26/2015)... ... 26, 2015 , ... Indosoft Inc., developer and distributor of the world-class Asterisk ... system efficiency and reliability. , The new Q-Suite 6 platform is based on the ... locking itself into a specific piece of software for many key components of the ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... all, Water For Empowerment ™ attracts volunteers together who want to combine ... empowering women as key stakeholders in the process. The non-profit launched its first ...
(Date:11/25/2015)... ... November 25, 2015 , ... Finnleo, a leader in ... on several models of traditional and far-infrared saunas. , For traditional saunas, ... the most traditional Finnish sauna wood, and Finnleo uses only European Grade A Nordic ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... --> --> Juntendo University Hospital ... weighting of MRI for patients with Multiple Sclerosis (MS) ... with SyntheticMR in order to use SyMRI in clinical research ... generate multiple contrast images from a single scan and adjust ... it possible to both fine tune images and recreate additional ...
(Date:11/26/2015)... ) has ... Future Horizons and Growth Strategies in the ... Shares, Country Segment Forecasts, Competitive Intelligence, Emerging ... --> ) has announced the ... and Growth Strategies in the French Drugs ...
(Date:11/26/2015)... 26, 2015 Research and Markets ( ... Wound Care Market by Type (Dressings, Therapy Devices, Active ... Facility, Out-Patient Facility), and Geography - Global Forecast to ... --> --> The purpose of ... forecast of the global advanced wound care market. It ...
Breaking Medicine Technology: