Navigation Links
Pitt research sheds new light on virus associated with developmental delays and deafness
Date:11/28/2012

PITTSBURGH, Nov. 28, 2012 A new study published online in PLOS ONE reveals that primitive human stem cells are resistant to human cytomegalovirus (HCMV), one of the leading prenatal causes of congenital intellectual disability, deafness and deformities worldwide. Researchers from the University of Pittsburgh School of Medicine found that as stem cells and other primitive cells mature into neurons, they become more susceptible to HCMV, which could allow them to find effective treatments for the virus and to prevent its potentially devastating consequences.

"Previous studies have focused on other species and other cell types, but those studies did not evaluate what the cytomegalovirus does to human brain cells," said Vishwajit Nimgaonkar, M.D., Ph.D., professor of psychiatry at the University of Pittsburgh School of Medicine, and senior author of the report. "This study is the first of its kind, and the first to discover that primitive stem cells are actually resistant to HCMV."

Access to cultured human neurons, necessary to understand the pathogenic effects of HCMV, has been limited by difficulties in growing the brain cells in the laboratory. Yet through human-induced pluripotent stem (iPS) cells, researchers were able to overcome this hurdle.

The study authors derived live iPS cells by reprogramming cells called fibroblasts obtained from human skin biopsies. The iPS cells were then induced to mature through several stages into neurons, the primary cells in the brain. The researchers were able to evaluate the patterns of damage caused by HCMV on all these cells.

The research findings suggest:

  • Human iPS cells do not permit a full viral replication cycle, suggesting for the first time that these cells can resist CMV infection
  • CMV infection distorts iPS cell differentiation into neurons, and that may be a mechanism by which infected babies develop impairments of brain maturation and intellect
    '/>"/>

Contact: Cristina Mestre
MestreCA@upmc.edu
412-586-9776
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. DFG funds new Collaborative Research Center at the Mainz University Medical Center
2. Researchers report first success of targeted therapy in most common non-small cell lung cancer
3. Dr. Deluca of Kessler Foundation receives medical excellence award for MS research
4. Research from ASCOS Quality Care Symposium shows advances and challenges in improving the quality of cancer care
5. Scripps Research Institute study points to potential new therapies for cancer and other diseases
6. USC, Oxford researchers find high fructose corn syrup-global prevalence of diabetes link
7. The Journal of Nursing Research receives impact factor ranking
8. Researchers study cry acoustics to determine risk for autism
9. Researchers explore social media as preventative method for infectious diseases
10. New mechanism for cancer progression discovered by UNC and Harvard researchers
11. Research reveals new understanding of X chromosome inactivation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... 2014 Expert witness work is in! ... from its 2014 Expert Witness Fees & Practices Survey. ... demand and compensation for qualified and credentialed expert witnesses ... 16-year history. , The nearly 600 experts surveyed ... expert work, an increase of 3.2% from ExpertPages’ 2012 ...
(Date:9/21/2014)... "I wanted to be able to obtain ... foul-tasting energy drinks," said an inventor from Fresh Meadows, ... drink plain, old coffee. That is why I came ... ENERG CHEWING GUM to provide a healthy energy boost ... contains nutritious vitamins, minerals and antioxidants. It also features ...
(Date:9/21/2014)... September 21, 2014 "I want to ... and back but haven’t the money for chiropractors," said ... to have such a product for myself." , The ... to stretch the thigh muscles and align the spine ... as relieves discomfort of pinched nerves. Compact and easy ...
(Date:9/21/2014)... (PRWEB) September 21, 2014 Best Cheap ... recently announced that Arvixe, Bluehost and GreenGeeks are the ... to find a good reseller hosting supplier. Actually, these ... server speed and customer support. People can get the ... manager says. , According to the manager, reseller ...
(Date:9/21/2014)... To accommodate the ever-growing customer base, Angeldress.co.uk decided ... items. Recently, the company has unveiled its 2014 ... elegant wedding gowns, Angeldress.co.uk wants to make sure that ... easy way. Its high quality vintage wedding outfits are ... to 62% off. , Online shopping is becoming more ...
Breaking Medicine News(10 mins):Health News:ExpertPages 2014 Survey Reports Expert Witness Hourly Fees Record All-Time Highs as Demand for Qualified Experts Continues to Grow 2Health News:Best Cheap Hosting USA Announces The Best Reseller Hosting Suppliers In 2014 2Health News:Angeldress.co.uk Launches New Range Of 2014 Vintage Wedding Dresses In Its Online Store 2
... Nov. 17 Shopko Stores Operating Co., LLC announced the ... www.shopko.com . Shopko partnered with SpeedFC, a ... advance the Company,s online selling initiatives. , The new online ... in apparel, home, accessories, gift cards and more. The site ...
... is one of 12 sites nationwide participating in the ... treatment for Alzheimer,s disease. The study is the first ... The experimental treatment utilizes a viral-based gene transfer ... naturally occurring protein that helps maintain nerve cell survival ...
... a new model of comprehensive health care for people ... Economics Award for Innovation in Practice Improvement from the ... Teachers of Family Medicine (STFM) and Medical Economics magazine. ... the Guided Care study and director of the Roger ...
... Hughes Medical Institute (HHMI) today committed four years, ... program between Rice University and the University of ... program -- founded with a 2006 HHMI grant ... bioengineering program and M.D. Anderson,s internationally renowned clinical ...
... ... successfully blended custom EDM machining and lights-out automation for greater speed and accuracy for ... are critical to optimized performance. , ... Tucker, GA (PRWEB) November 17, 2009 -- A proprietary new technology ...
... might help reduce heart attacks, researchers say , ... soybeans boosts levels of an important omega-3 fatty acid in ... U.S. researchers say. , They created soybeans that produce oils ... body into an omega-3 fatty acid called eicosapentaenoic acid (EPA). ...
Cached Medicine News:Health News:Shopko Announces Launch of e-Commerce Platform 2Health News:Mount Sinai researchers to test first gene therapy For Alzheimer's patients 2Health News:'Guided Care' receives Award for Innovation in Practice Improvement 2Health News:New funds for Rice, M.D. Anderson program 2Health News:Proprietary EDM Machining Technology Boosts Speed and Accuracy for Medical Components 2Health News:Biotech Soybeans Good Source of Omega-3 2
(Date:9/19/2014)... , Sept. 19, 2014  Diplomat, the nation,s largest ... David Dreyer to the Board of Directors on ... and will also serve as chair of the Audit ... years of accounting, financial, compliance and operating experience in ... has served as chief financial officer, chief operating officer ...
(Date:9/19/2014)... WOONSOCKET, R.I. , Sept. 19, 2014 Five MinuteClinic ... Memphis metropolitan area. Three clinics opened in ... earlier this month. A fourth clinic will be added in ... in Bartlett is expected to open October ... medical clinics in the United States . ...
(Date:9/19/2014)... According to market research ... Industrial, & Laboratory), Industry (Food, Pharmaceutical, Biotechnology, Surgical ... & Geography - Global Trends & Forecast to ... lyophilization market on the basis of various types, ... the market size of each of these segments ...
Breaking Medicine Technology:David Dreyer Appointed to Diplomat Board of Directors 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 2MinuteClinic Walk-in Medical Clinics Opening in Memphis 3Lyophilization Market Worth $5,121.5 Million by 2019 2Lyophilization Market Worth $5,121.5 Million by 2019 3
... Inc., (Ticker: AVTC) ( www.autoretail.com ), is a leading ... for use in hospitals, pharmacies, medical offices and clinics. ... reduce and even eliminate prescription medicine dispensing errors.   ... of Pharmacy Practice reviewed 60 research papers that analyzed ...
... of reusable medical device cleaning validations, resulting from the U.S. ... CFR 610 , is discussed in a new management brief ... . The FDA,s proposed amendments to 21 CFR ... Register on June 21, 2011, for review and comment, ...
Cached Medicine Technology:Automated Medicine Dispensing Units Developed by AVT Can Reduce Errors 2Summary of Proposed Changes to 21 CFR 610 is Detailed in New Management Brief from Microtest Laboratories 2
... Axiovert 40 inverted ... you have ever expected from a microscope in ... outstanding quality, and functionality. Axiovert 40 has been ... safe as possible thus increasing the efficiency ...
... is an advanced inverted microscope ... exclusive CFI60 optical system, extendible ... it ideal for high precision, ... inverted microscope to take full ...
... Eclipse TE2000E is an advanced inverted microscope ... five imaging ports, high resolution CFI60 optics, ... perfect imaging workstation. In addition, its super-nanoprecision ... control is perfect for precise imaging in ...
... The IX71's modular frame ... 9 access ports for ... devices. Up to four ... access to a primary ...
Medicine Products: