Navigation Links
Pitt part of $100 million NHLBI 'Bench to Bassinet' effort in congenital heart disease
Date:11/17/2009

PITTSBURGH, Nov. 17 Developmental biologists at the University of Pittsburgh have been chosen to participate in a $100 million federal "Bench to Bassinet" network that is dedicated to learning about the formation of the cardiovascular system and applying that knowledge to create new diagnostic and intervention strategies for congenital heart disease.

The Pitt team, led by Cecilia Lo, Ph.D., chair of the Department of Developmental Biology, School of Medicine, will use the mouse as a model system to identify and describe the core set of genes that play an essential role in producing structural heart defects, which include holes in the heart walls, transposition of major blood vessels that connect to the heart and other problems of cardiac development that can affect up to 1 percent of live births.

"Ultimately, we want to build a diagnostic chip that can rapidly and accurately identify the genetic root causes of specific heart defects," Dr. Lo explained. "That could enable us to examine how these genes influence disease progression, correlate them with long-term outcomes and better tailor treatment."

To find the genetic determinants of congenital heart disease, her $8.6 million project will expose fetal mice to a chemical that increases the likelihood of gene mutations and use non-invasive fetal echocardiography to spot any heart defects that result. Then the DNA of the affected mice will be examined to identify the gene changes that caused the abnormality. A zebrafish model will be used as a quick bioassay to validate the findings.

Dr. Lo is particularly interested in mutations that affect the function of cilia, which are hair-like projections on cells that are best known for moving fluids along tissue surfaces. "We now know cilia are critical to heart development in the fetus," she said. "For example, they help to correctly orient the heart, which is a left-right asymmetrical organ. This asymmetry is crucial for normal fu
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New York Personal Injury Law Firm Cellino & Barnes Wins $3.25 Million Settlement For Workers Injured in Truck Accident
2. Ignite Institute Receives Support from Commonwealth of Virginia, Fairfax County, $200 Million in Initial Funding and Financial Backing, Locks in Key Regional Partner
3. W.K. Kellogg Foundation Grants $32.5 Million to Improve Access to Fresh Food and Physical Activity for Children
4. Prism and Medical College of Wisconsin investigators receive $1.6 million NIH grant to develop advanced medical imaging tools
5. The Ensign Group Secures $40 Million Loan From GE Capital, Healthcare Financial Services
6. Prioritizing low-cost, simple health measures would save 2.5 million child lives a year
7. Echo Therapeutics Announces $3 Million Financing
8. 22 Million Sickened by Swine Flu in 6 Months
9. ULURU Inc. to Raise $1.5 Million in Registered Direct Offering
10. Employment Policies Institute Launches $10 Million Campaign Urging the Public to Rethink Health Care Reform
11. House Health Reform Plan Will Benefit Millions of Illinoisans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... National Teen Driver Safety Week is October 19-25, ... Pediatrics (Ohio AAP, http://www.ohioaap.org ) is joining the National ... drivers to talk to their teens and always set the ... are the leading cause of death for U.S. teens. In ... and 859 (42%) of those teen drivers were killed in ...
(Date:10/20/2014)... It’s hard to imagine what it’s like to live without ... world, it’s a reality. And while new shoes are considered ... walk barefoot on rocky terrain or sewage-lined streets just to ... , Buckner International's Shoes for Orphan Souls ... to encourage support for Air1 and while also providing new ...
(Date:10/20/2014)... Silver Spring, Maryland, USA (PRWEB) October 20, 2014 ... readers or to track interventions? Here comes a wonderful ... leading mobile app development company helped its ... track Intervention more efficiently. The app is designed for ... iPad, and iPod touch. This app is optimized for ...
(Date:10/19/2014)... October 20, 2014 Recently, BambooIndustry.com, one ... unveiled its new range of bamboo deckings . ... these natural items; they are now available at deeply ... people, it is hard to overstate the significance of ... attention to online services. The company’s workers are striving ...
(Date:10/19/2014)... (PRWEB) October 20, 2014 Having been working ... a good knowledge of customer needs. According to James, one ... covered with dazzling sequins, or with high-low skirts that add ... a huge demand. Recently, LunaDress has unveiled its new selection ... of fact, the company’s brand new items are available in ...
Breaking Medicine News(10 mins):Health News:Ohio AAP Promotes National Teen Driver Safety Week 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 2Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 3Health News:High Quality Bamboo Deckings, New Items Unveiled By BambooIndustry.com 2Health News:2014 Long Prom Dresses From LunaDress Now Available In Over 20 Popular Designs 2
... 12 HOUR for use in treating symptoms of seasonal allergic ... a combination of desloratadine 2.5 mg and pseudoephedrine sulfate, USP ... in persons above 12 years of age. The drug ... non-nasal symptoms occurring due to seasonal allergic rhinitis. Two ...
... India’s National Institute of Immunology are reported to have ... how the tuberculosis (TB) bacteria survives in the human ... and more effective medicines to combat the disease, which ... world annually. The research team led by Rajesh S. ...
... new survey has found that many British workers are not averse ... be sent in by text messages or the typical cough and ... is the widespread dissatisfaction with holiday allowance for British workers, who ... ,'Early February is a very popular time for ...
... leaders, particularly in South Asia to prohibit smoking among the ... the British Medical Journal (BMJ). The help of the Muslim ... ,The researchers analyzed data on the prevalence of smoking ... Smoking rates in each of these countries is significantly higher ...
... topic for several years, gaining momentum over the past one ... physiological responses to them. A new study, published in the ... effect of types of placebo devices Vs pills on patients ... placebos to gauge the effectiveness of novel treatment methods, but ...
... of Health said that conventional tests fail to identify smaller blood ... sign because they do not have the bulky clogs in main ... shortness of breath and are at an increased risk of a ... is very common among both men and women and causes maximum ...
Cached Medicine News:Health News:Placing a Finger on Responses to Placebo Types 2
(Date:10/17/2014)... , Oct. 17, 2014 A victim of medical ... doctor with a history of alcohol abuse, a ... Yes on Prop 46 today, highlighting how Prop 46 will ... alcohol testing. The ad pictures a doctor ... "911-Report To ER."  Proposition 46 will enact the first law ...
(Date:10/17/2014)... , Oct. 17, 2014 The following ... Technology Policy: The Green Park Collaborative ... public and private payers, medical device and pharmaceutical ... other experts January 12, 2015 at its first ... of weight loss treatments.  Participants will discuss study ...
(Date:10/17/2014)... Conn. , Oct. 17, 2014  UBM Medica ... online community for endocrinologists and other clinicians who treat ... comprehensive coverage on effective use of insulin .  ... eventually require insulin replacement therapy – daily ... for the progressive decline in the function of pancreatic ...
Breaking Medicine Technology:Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 2Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 3Victim Of Negligence At Hands Of A Drunk Doctor, A Physician and Consumer Advocates Release New Yes on 46 TV Ad, "On Call" 4Green Park Collaborative to Discuss Comparative Effectiveness and Value of Weight Loss Treatments 2Endocrinology Network Features Special Coverage on Effective Use of Insulin 2Endocrinology Network Features Special Coverage on Effective Use of Insulin 3
... 2011 What:   Investigators ... of FDA,s 510(k) regulatory pathway—through which more than 90% ... it. The study is the most comprehensive survey to ... Center for Devices and Radiological Health (CDRH) is currently ...
... SOUTH SAN FRANCISCO, Calif., May 18, 2011 Onyx ... the presentation of several studies evaluating carfilzomib, a selective, ... inhibitor, in hematological cancers at the 47th American Society ... in Chicago, IL. "The data that will ...
Cached Medicine Technology:Findings From Largest Industry Assessment of 510(k) Process to be Released on May 24, 2011 2Onyx Pharmaceuticals Announces Data Presentations of Carfilzomib and ONX 0912 at 47th American Society of Clinical Oncology Annual Meeting 2Onyx Pharmaceuticals Announces Data Presentations of Carfilzomib and ONX 0912 at 47th American Society of Clinical Oncology Annual Meeting 3Onyx Pharmaceuticals Announces Data Presentations of Carfilzomib and ONX 0912 at 47th American Society of Clinical Oncology Annual Meeting 4Onyx Pharmaceuticals Announces Data Presentations of Carfilzomib and ONX 0912 at 47th American Society of Clinical Oncology Annual Meeting 5Onyx Pharmaceuticals Announces Data Presentations of Carfilzomib and ONX 0912 at 47th American Society of Clinical Oncology Annual Meeting 6Onyx Pharmaceuticals Announces Data Presentations of Carfilzomib and ONX 0912 at 47th American Society of Clinical Oncology Annual Meeting 7
... surface preparation is the Leica SM2500 sledge ... ,Ultramilling is often a viable alternative to ... preparation. Especially with difficult specimens, where hard ... side in one specimen block, the results ...
... The Trellis Infusion Catheter enables the physician ... physician-specified fluid, and disperse the agent by ... The Trellis is a multi-lumen catheter with ... end and infusion holes located between these ...
... The SENSAR® Acrylic IOL with OptiEdge ... performance, long-term refractive stability, and excellent handling. ... has had no reports of vacuoles; the ... internal reflections and provide 360 degrees of ...
... acrylic foldable single-piece posterior chamber lenses are ... human crystalline lens in the visual correction ... age and older. The optical portion consists ... material. These lenses have biconvex optics and ...
Medicine Products: