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Pitt-led research provides insight into development of congenital circulatory defects
Date:7/8/2008

ped AVMs on the side of the dead-end vesselleft, right, or boththat happened to receive blood flow first.

While AVMs in humans are generally thought to form in utero, they typically are discovered only when they cause a serious health problem later in life. AVMs can form in various organs, including the brain, lungs, spinal cord, and liver. By diverting blood, the misconnections rob parts of the body of nutrients and oxygen. The fragile fusions are prone to rupturing and hemorrhaging; a ruptured AVM in the brain can cause a stroke.

"We discover AVMs in humans when something goes wrong and we can never go back and trace the shunt's development," Roman said. "Only when we fully understand the mechanisms leading to these malformations will we be able to develop better diagnostic tests and preventative treatments to pinpoint the best time to intervene."


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Contact: Morgan Kelly
mekelly@pitt.edu
412-624-4356
University of Pittsburgh
Source:Eurekalert

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