Navigation Links
Pitt-led research provides insight into development of congenital circulatory defects
Date:7/8/2008

PITTSBURGHUniversity of Pittsburgh-led researchers could provide new insight into how two common congenital circulatory problemsaortic arch deformity and arteriovenous malformations (AVMs)develop in humans, as reported in the June 15 edition of Developmental Biology.

Led by Beth Roman, an assistant professor of biological sciences in Pitt's School of Arts and Sciences, the team created the first complete published description of how aortic arch vessels form and, in a separate finding also described in the paper, determined that AVMswherein an artery fuses with a vein and diverts blood flowcan form as a result of combined genetic and physiological factors and not solely because of genetics.

The team created the aortic arch vessel development model from zebrafish embryos, which develop similarly to humans but more rapidly. In humans, the aortic arch vessels contribute to several of the body's major arteries and often develop improperly, resulting in a wide range of vascular defects. The model could allow for a better understanding of the genetic program that governs aortic arch development, and therefore help in predicting abnormalities and determining when and how to intervene.

From the model, the team discovered that the gene unc45a plays a critical and previously unknown role in the formation of the aortic arch vesselsand that mutations in that gene can result in AVMs. In zebrafish harboring the mutation, two aortic arch vessels failed to connect properly to the body's major artery, the dorsal aorta. Instead, dead-end vessels formed then swelled with blood until they touched and fused with a nearby vein.

AVMs typically form embryonically, but the particular AVMs Roman's team observed did not form in the absence of blood flow, indicating that they were not genetically hardwired, she said. Additionally, AVM formation was inconsistent in terms of location on the aortic arch vessel, Roman said. The mutants randomly developed AVMs on the side of the dead-end vesselleft, right, or boththat happened to receive blood flow first.

While AVMs in humans are generally thought to form in utero, they typically are discovered only when they cause a serious health problem later in life. AVMs can form in various organs, including the brain, lungs, spinal cord, and liver. By diverting blood, the misconnections rob parts of the body of nutrients and oxygen. The fragile fusions are prone to rupturing and hemorrhaging; a ruptured AVM in the brain can cause a stroke.

"We discover AVMs in humans when something goes wrong and we can never go back and trace the shunt's development," Roman said. "Only when we fully understand the mechanisms leading to these malformations will we be able to develop better diagnostic tests and preventative treatments to pinpoint the best time to intervene."


'/>"/>

Contact: Morgan Kelly
mekelly@pitt.edu
412-624-4356
University of Pittsburgh
Source:Eurekalert

Related medicine news :

1. Leading Plastic Surgeons Reveal Revolution in Stem Cell Research Has its Roots in Beverly Hills Plastic Surgery
2. Orange County research program aims to improve severe trauma survival rates
3. Autism Research Institute Launches Mobile Website
4. Jefferson researchers show antibody to breast cancer-secreted protein blocks metastasis
5. Wake Forest researchers say popular fish contains potentially dangerous fatty acid combination
6. New research reveals ultraviolet light therapy is as beneficial for darker skin as lighter skin
7. Ivy Foundation Funds New Brain Cancer Research Consortium : $3M Stage I Project Aims to Improve Personalized Medicine for Patients
8. The Henry H. Kessler Foundation Appoints New Vice President for Research and Strengthens Relationship With Current Research Luminary
9. The Foundation for Accelerated Vascular Research Grants $150,000 Wylie Scholar Award for Blood Vessel Research
10. Nuvo Research and Paladin announce amendments to Pennsaid and Pennsaid Plus agreements
11. GRAS Proudly Announces Photometrica Version 2.0. Hailed as a Brilliant Solution for More Productive Astronomical Research by Those Engaged in Photometry Using the Global-Rent-a-scope Telescope Systems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/16/2017)... (PRWEB) , ... August 16, 2017 , ... TopConsumerReviews.com recently ... Lab Testing . , The healthcare industry in the United States has undergone ... are the days of needing to have a doctor’s order to get a blood ...
(Date:8/16/2017)... Petaluma, CA (PRWEB) , ... August 16, 2017 ... ... donate and distribute $100,000 in AED (Automated External Defibrillator) machines to their local ... an AED device from Arrow Benefits Group. AED machines are an integral part ...
(Date:8/16/2017)... ... ... of A Child” is the creation of published author, Pauline DiBenedetto. , “As my mother ... was in such great pain, my mother thought that her time has come. Once I ... I was about eight years old, when I had a vision of my own, that ...
(Date:8/15/2017)... Los Angeles, CA (PRWEB) , ... August 15, 2017 , ... The city of Los ... styles exist in harmony with “Cali Style”. LA’s Top Style List, a website that spotlights ... to help the public wear their wardrobe all year long. , According to the senior ...
(Date:8/15/2017)... ... August 15, 2017 , ... The V Foundation ... 19th Annual V Foundation Wine Celebration raised nearly $9 million for cancer research ... million in “Fund-A-Need” donations to support the study of BRCA mutation research in ...
Breaking Medicine News(10 mins):
(Date:7/27/2017)... WARSAW, Ind., July 27, 2017  Zimmer Biomet Holdings, ... the quarter ended June 30, 2017.  The Company reported ... of 1.1% over the prior year period, and an ... approximately 240 basis points of contribution from the LDR ... from the second quarter of 2016, or 0.3% on ...
(Date:7/26/2017)... Fla. , July 26, 2017 Sancilio ... enrollment of our clinical trial evaluating Altemia TM , ... Anemia (SCA) and Sickle Cell Disease (SCD). The SCOT ... evaluate the efficacy and safety of Altemia TM ... is conducted under US IND 125274. ...
(Date:7/24/2017)... N.Y. , July 24, 2017 IBM (NYSE: ... the Gartner Magic Quadrant for Solid-State Arrays (SSA) for the ... According to Gartner, "Vendors in the Leaders ... and Completeness of Vision. A vendor in the Leaders quadrant ... needed to drive the acceptance of new technologies. These vendors ...
Breaking Medicine Technology: