Navigation Links
Pitt/NIH team find way to protect healthy cells from radiation damage
Date:10/21/2009

PITTSBURGH, Oct. 21 Researchers at the University of Pittsburgh School of Medicine and the National Cancer Institute (NCI), part of the National Institutes of Health, may be hot on the heels of a Holy Grail of cancer therapy: They have found a way to not only protect healthy tissue from the toxic effects of radiation treatment, but also increase tumor death. The findings appear today in Science Translational Medicine.

More than half of all cancer patients are treated at least in part with radiation, said study co-author Jeff S. Isenberg, M.D., M.P.H., associate professor, Division of Pulmonary, Allergy, and Critical Care Medicine, Pitt School of Medicine. But the same radiation that kills cancer cells can also destroy healthy ones, causing side effects such as nausea and vomiting, skin sores and rashes, and weakness and fatigue. Long-term radiation exposure can lead to the scarring and death of normal tissue.

He and his NCI colleagues have identified a biochemical signaling pathway that can profoundly influence what happens to both cancerous and healthy cells when they are exposed to radiation. In mouse experiments, they found that blocking a molecule called thrombospondin-1 from binding to its cell surface receptor, called CD47, affords normal tissues nearly complete protection from both standard and very high doses of radiation.

"We almost couldn't believe what we were seeing," Dr. Isenberg said. "This dramatic protective effect occurred in skin, muscle and bone marrow cells, which is very encouraging. Cells that might have died of radiation exposure remained viable and functional when pre-treated with agents that interfere with the thrombospondin-1/CD47 pathway."

There have been concerns that approaches to spare healthy cells will risk inadvertently protecting tumor cells, noted senior author David D. Roberts, Ph.D., of the NCI's Center for Cancer Research. But, he added, "in our experiments, suppression of CD47 robustly delayed the regrowth of tumors in radiation-treated mice."

It's not yet clear why disrupting the CD47 signaling pathway leads to these effects, the researchers said. It's possible that radiation impairs the immune response to tumors even while killing tumor cells, but suppression of CD47 keeps the immune cells safe. Decreasing CD47 levels on tumor cells also could make them more sensitive to attack by the patient's immune system after treatment. Or, suppression of injury to vascular cells might improve blood flow to allow naturally occurring anti-tumor immunity to reach cancer cells more easily.

The researchers are already exploring the signaling pathway's role in several other domains, noted Mark Gladwin, M.D., chief of Pitt's Division of Pulmonary, Allergy, and Critical Care Medicine and director of the Vascular Medicine Institute, where Dr. Isenberg is a principal investigator.

"Dr. Isenberg and his team are examining multiple disease treatment strategies for pulmonary hypertension, wound healing, sickle cell disease and heart attacks, based on the blockade of the thrombospondin-1/CD47 pathway," he said.


'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Related medicine news :

1. Kimberly-Clark Professional Announces Clean Hands Campaign and Flu Fighters Contest To Help Protect Office Workers From Flu
2. Maternal HIV-1 treatment protects against transmission to newborns
3. Want Sun Protection? Wear Red or Blue
4. Some color shades offer better protection against sun’s ultraviolet rays
5. Focused Radiation Protects Tumor Patients Brain Function
6. Alcohol May Help Protect Trauma Patients
7. UCF Athletes Set Example While Getting Protected Against Flu
8. Penn study asks, protection or peril? Gun possession of questionable value in an assault
9. Penn Study Asks, Protection or Peril? Gun Possession of Questionable Value in an Assault
10. Study Shows College Students Are Not Following CDC Recommendations to Help Protect Themselves from H1N1 and Other Threatening Germs
11. Improved Screening for Jaundice Can Protect Newborns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids ... Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, ... run is geared towards children of all ages; it is a non-competitive, non-timed event, ...
(Date:10/13/2017)... ... ... Journey: From the Mountains to the Mission Field”: the story of a missionary couple ... From the Mountains to the Mission Field” is the creation of published author, Carole ... and currently teaches a class of ladies at her church, which she has taught ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of ... announced today its plans to open a flagship location in Covington, LA at 401 ... Rooms To Go store next to Office Depot in the Holiday Square shopping center. ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... leader in post-acute health care, have expanded their existing home health joint venture ... , AccentCare has been operating a joint venture home health company with Asante, ...
(Date:10/12/2017)... ... ... Leading pediatric oncology experts at Children’s National Health System will join ... International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by Jeffrey Dome, ... at Children’s National, and Stephen P. Hunger, M.D., Chief of the Division of ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... MENLO PARK, Calif. , Oct. 11, 2017 /PRNewswire/ ... a national scientific team that developed an innovative way ... and quantity of the delivery of new drugs. ... the 2017 Fall Clinical Dermatology Conference will show how ... Massachusetts General Hospital, Harvard Medical School used a suite ...
(Date:10/11/2017)... 2017  True Health, a leader in integrated ... during National Breast Cancer Awareness month to educate ... Research recently published ... more than 10 million American women are at ... or BRCA2 and have not had testing. These mutations ...
(Date:10/10/2017)... received FDA 510(k) clearance in May 2017 for its highly anticipated ... for endoscopy environments. An innovative secondary monitor solution, ZeroWire Mobile ... the improvement of patient outcomes, procedural efficiency, and the lowering of ... ... By ...
Breaking Medicine Technology: