Navigation Links
Pitt/Magee research finds women with preeclampsia have fewer blood vessel precursor cells

PITTSBURGH, April 6 Compared to women with uncomplicated pregnancies, women with preeclampsia have reduced numbers of special cells that are thought to help grow and maintain blood vessels, according to a study by researchers at the Magee-Womens Research Institute (MWRI) and the University of Pittsburgh School of Medicine. The findings are available online in Reproductive Sciences.

As a healthy pregnancy progresses, two types of endothelial progenitor cells (EPCs) increase in number, possibly indicating the augmentation of the mother's cardiovascular system to meet the need of the growing fetus, explained senior author Carl A. Hubel, Ph.D., an MWRI associate investigator and an associate professor of obstetrics, gynecology and reproductive sciences at Pitt.

But this adaptation doesn't happen in patients with preeclampsia, a pregnancy disorder characterized by high blood pressure and protein overload in the third trimester. Preeclampsia is the leading cause of preterm labor.

"When we examined blood samples from these women, we found they had far fewer EPCs," Dr. Hubel said. "We wouldn't have been able to tell them apart from women who weren't pregnant or men."

The researchers drew blood samples during the first, second or third trimester from 52 healthy women expecting their first child; 14 with preeclampsia expecting their first child; and 13 women who had never been pregnant.

In addition to the reduced numbers of EPCs, preeclampsia samples showed alterations in key signaling molecules that may contribute to the mobilization of precursor cells into the circulation.

The researchers also collected third trimester blood samples from other groups of 11 women with preeclampsia and 12 healthy pregnant women. From those samples, they cultured cells known as circulating angiogenic cells (CACs), which are a type of progenitor cell thought to secrete growth factors to support cells that regenerate the vascular endothelium, or blood vessel lining. Cultures from preeclampsia samples grew fewer CACs.

"Still, it's not clear to us whether these differences are the cause of preeclampsia or are a consequence of it," Dr. Hubel noted. "We need to monitor women throughout pregnancy to see if we can figure out what came first, as well as get a better understanding of how all these cells work."

He added that studying women with preeclampsia after pregnancy also would be valuable because of the relationship between low numbers of EPCs and the development of cardiovascular disease.


Contact: Anita Srikameswaran
University of Pittsburgh Schools of the Health Sciences

Related medicine news :

1. NOSCAR announces 2010 NOTES research award winners
2. What Causes A Person To Be Mentally Ill? Author Who Has Spent Decades Researching Topic Says He Has the Answer
3. Researchers aim for consensus on measuring the impact of visual impairment
4. Researchers Boost Post-Heart Attack Survival in Mice
5. Researchers quantify benefits of minimally invasive removal of hard-to-reach tumors
6. UD team develops new method for producing proteins critical to medical research
7. Researchers design self-test for memory disorders
8. Accumed Research Associates Launches Official Website
9. McMaster researcher leads development of promising drug for inflammation
10. European hematologist receives award to conduct research in US
11. Research shows why we forget to take our medicine, and what we can do about it
Post Your Comments:
(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
(Date:6/24/2016)... ... ... Comfort Keepers® of San Diego, CA is excited to announce they are ... drive cancer patients to and from their cancer treatments. Comfort Keepers provides quality ... and ongoing independence. Getting to and from medical treatments is one of the ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine presented its first-ever ... Medicine conference in Ponte Vedra Beach, FL. The awards honor the outstanding work ... Practice and Pediatric Emergency Medicine Practice. , “With this award, we recognize ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... --  Pulmatrix, Inc ., (NASDAQ: PULM ), ... today that it was added to the Russell Microcap ... set of U.S. and global equity indexes on June ... for Pulmatrix," said Chief Executive Officer Robert Clarke ... in developing drugs for crucial unmet medical needs, and ...
(Date:6/23/2016)... 2016  MedSource announced today that it has ... solution of choice.  This latest decision demonstrates MedSource,s ... their clients by offering a state-of-the-art electronic data ... nowEDC as the EDC platform of choice in ... "nowEDC has long been a preferred EDC platform ...
(Date:6/23/2016)... -- Research and Markets has announced the ... (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, ... Global Forecast to 2021" report to their offering. ... pharmaceutical excipients market is projected to reach USD 8.1 ... the forecast period 2016 to 2021. ...
Breaking Medicine Technology: