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Pitt/Children's Hospital team: Cell membrane proteins could provide targets for broader vaccines
Date:12/22/2011

tibodies, with the bacteria. They found that the animals could become immunized against repeat infection as long as IL-17 was unblocked, allowing Th17 cells to develop an immunological memory of the Klebsiella bacteria.

The researchers determined also that while antibodies react to sugar complexes called polysaccharides in the bacterial coat or capsule, Th17 cells respond to protein complexes in the cell membrane. Those proteins, which are integral to the structure of the cell membrane, tend to be similar across bacterial strains, unlike the capsular polysaccharides, which are variable, Dr. Kolls said.

"Some current vaccines require generating a response to a number of these capsular sugars for effective immunization," he said. "An approach that harnesses the stability of the Th17 cell response to common proteins has the potential to simplify vaccination and provide a broader spectrum of coverage. This strategy may be particularly useful against bacteria that have diverse capsular sugars or multi-drug resistant organisms."


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Contact: Anita Srikameswaran
srikamav@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

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