Navigation Links
Pitt Bioinformatics Study Provides Clues to Relationship between Schizophrenia and Rheumatoid Arthritis
Date:2/24/2017

An in-depth computational analysis of genetic variants implicated in both schizophrenia and rheumatoid arthritis by researchers at the University of Pittsburgh points to eight genes that may explain why susceptibility to one of the disorders could place individuals at lower risk for the other, according to the results of a study published today in the journal npj Schizophrenia.

“There is a wealth of genomic data on both schizophrenia and rheumatoid arthritis. Analyzing it jointly with known protein interaction information could provide invaluable clues to the relationship between the diseases and also shed light on their shared roots,” said Madhavi Ganapathiraju Ph.D., associate professor of biomedical informatics at the University of Pittsburgh School of Medicine and senior author of the study.

While schizophrenia is a psychiatric disorder of unknown origin and rheumatoid arthritis is an autoimmune disease of the joints that occurs as a result of the body’s immune system attacking its own cells, both disorders are thought to be influenced by multiple genetic risk factors modified by the environment.

“Several previous research studies have hinted at a potential inverse relationship in the prevalence and risk for the two disorders, so we wondered if individual genetic variants may exist that could have opposing effects on the risk of schizophrenia and rheumatoid arthritis,” said co-senior author Vishwajit Nimgaonkar M.D., Ph.D., professor of psychiatry at Pitt’s School of Medicine and human genetics at Pitt’s Graduate School of Public Health.

The researchers first analyzed two large databases of genetic variants significantly associated with either schizophrenia or rheumatoid arthritis. They identified 18 unique variants, also known as single nucleotide polymorphisms (SNPs) that were located in the HLA region of the genome that harbors genes associated with immune function. The variants appeared to confer different risk for schizophrenia or rheumatoid arthritis. As the SNPs were located near eight known genes in this region, the authors suggested those genes might lead to dysfunction in both schizophrenia and rheumatoid arthritis. Proteins encoded by two of these eight genes, HLA-B and HLA-C, are present in both brain and immune cells.

Analysis of proteins that interact with these eight genes using a computational model developed last year by Ganapathiraju’s team called High-Precision Protein Interaction Prediction found more than 25 signaling pathways with proteins common to both rheumatoid arthritis and schizophrenia signaling. Moreover, several of these pathways were associated with immune system function and inflammation.

The findings are encouraging because they support associations of the HLA gene region and immune function with schizophrenia and rheumatoid arthritis that were known over four decades ago, said Ganapathiraju.
Increasing evidence also suggests that a dysfunctional immune system could play a role in the development of schizophrenia.

“We believe that the research community studying these two disorders will find our results extremely helpful,” Nimgaonkar said.

The authors note that the study only focused on SNPs in known gene regions, and other mechanisms apart from the ones they described may also contribute to the diseases. However, the study has significantly narrowed the list of potential genes for examining the schizophrenia/rheumatoid arthritis relationship. Studying the functional relevance of the gene candidates in cells and tissues will provide insights into the two disorders, according to the researchers.

Other study authors included Tulsi A. Malavia, Srilakshmi Chaparala, Joel Wood, Kodavalli Chowdari, Ph.D., Konasale M. Prasad, M.D., and Lora McClain, Ph.D., all of Pitt; and Anil G. Jegga, D.V.M., of Cincinnati Children’s Hospital.

The research was funded by National Institutes of Health grants MH93480, MH093246, MH084053 and MH094564.

Read the full story at http://www.prweb.com/releases/2017/02/prweb14098592.htm.


'/>"/>
Source: PRWeb
Copyright©2017 Vocus, Inc.
All rights reserved


Related medicine news :

1. The First M&A in Aging Bioinformatics: Insilico Medicine and InSilicoScreen Join Forces to Take Human Aging Research to the Next Level
2. Atlas Regeneration Inc, New Company Focusing on Regeneration Bioinformatics and Regeneration Pharmacology, Has Officially Launched, Winston Salem, NC September 03, 2015
3. Insilico Medicine, Inc. Announces Collaboration with Baseport Research Laboratories to Accelerate Deep Learning Programs in Cancer and Aging Bioinformatics
4. A Software Engineer Who Wants to Save Lives – Recent College Graduate and Insilico Medicine Intern Prepares for a Career in Bioinformatics
5. Baltimore Poised to Become a World-Leading Hub of Multi-Billion Dollar Bioinformatics Industry
6. In the First Bioinformatics Hackathon, Computer Scientists Meeting in Russia Use their Computer Skills to Fight Deadly Diseases
7. Make New Discoveries: Qlucore Presents an Educational Bioinformatics Webinar
8. Bioinformatics Market: A fusion of Computers and Biological Data
9. Bioinformatics approach helps researchers find new uses for old drug
10. Bioinformatics profiling identifies a new mammalian clock gene
11. Global Bioinformatics Market 2014-2018 Industry size, Shares, Research Trends, Growth, Study, Analysis, Forecast
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/9/2018)... ... August 09, 2018 , ... Thousands ... have ruptured, according to cross-referenced data from The American Society of Plastic Surgeons ... rupture rates monitored by the FDA. As an MRI is recommended by FDA ...
(Date:8/9/2018)... (PRWEB) , ... August 09, 2018 , ... ... LegitScript certification. LegitScript is a new verification process that substance abuse providers must ... LegitScript certified means we can reach more people to help.” , Helping ...
(Date:8/9/2018)... , ... August 09, 2018 , ... ... been engaged as an Operating Partner and will have an exclusive relationship with ... role in the firm’s strategic planning, human capital sourcing, and deal origination, evaluation ...
(Date:8/7/2018)... ... ... Josh Sprague, Founder and CEO of athletic goods company Orange Mud , ... , Accompanied by colleague Marvin Sandoval and equipped with Orange Mud’s Gear Vest, ... iconic mountain bike race courses in the world.” , Beginning in the town ...
(Date:8/7/2018)... ... August 07, 2018 , ... ... of Nancy’s Probiotic Foods. These rich, cream-on-top-style yogurts are made with milk from ... milk that's high in omega-3 fatty acids. Nancy’s sources the milk from organic ...
Breaking Medicine News(10 mins):
(Date:8/2/2018)... ... August 02, 2018 , ... The American Heart ... awards on Wednesday, July 11, 2018, recognizing the hospital’s commitment to compliance with ... , , Get With The Guidelines®-Stroke Gold Plus Quality ...
(Date:8/2/2018)... COLLEGE PARK, Md. (PRWEB) , ... August 02, 2018 , ... ... will receive up to $7.7 million over 5 years from the National Institute of ... an ongoing tick research program to understand the immune responses of ticks that contribute ...
(Date:8/2/2018)... Md. (PRWEB) , ... August 02, 2018 , ... ... may have concerns about their child’s ability to communicate. These may include concerns ... treatment in schools by a speech-language pathologist. Here’s what parents should ...
Breaking Medicine Technology: