Navigation Links
Pitt: Targeted oxidation-blocker prevents secondary damage after traumatic brain injury
Date:8/26/2012

PITTSBURGH, Aug. 26, 2012 Treatment with an agent that blocks the oxidation of an important component of the mitochondrial membrane prevented the secondary damage of severe traumatic brain injury and preserved function that would otherwise have been impaired, according to a research team from the University of Pittsburgh School of Medicine, Graduate School of Public Health and Department of Chemistry in a report published online today in Nature Neuroscience.

Annually, an estimated 1.7 million Americans sustain a traumatic brain injury (TBI) due to traffic accidents, falls, assaults and sports participation, said the study's senior author Hlya Bayιr, M.D., associate professor, Department of Critical Care Medicine, University of Pittsburgh School of Medicine. She added that 52,000 of those injured die, and 85,000 are left with significant disability.

"We don't yet have a specific therapy for TBI, but can provide only supportive care to try to ease symptoms," Dr. Bayιr said. "Our study drug shows promise as a neuroprotective agent that might help address this important public health problem."

For the study, the research team conducted a global assessment of all the phospholipids in rat brain cells. This revealed that damage from TBI was nonrandom and mostly involved cardiolipin, a phospholipid that is found in the membranes that form mitochondria, the cell's powerhouse. They noted that in the healthy animal, only 10 of the 190 cardiolipin species were modified by oxygen, but after a brain injury, the number of oxidized species rose many-fold.

The researchers then developed an agent, called XJB-5-131, which can cross the blood-brain barrier and prevent the oxidation of cardiolipin. Using an established research model of severe TBI, the agent or a placebo was injected into the bloodstream of rats five minutes and again 24 hours after head injury.

In the weeks that followed, treated animals performed a
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Targeted therapeutics for colon cancer to be presented at AACR meeting
2. First targeted nanomedicine to enter human clinical studies
3. Highly targeted irradiation as good as whole breast radiotherapy in early stage cancer
4. Dana-Farber: Study reports first success of targeted therapy in type of non-small cell lung cancer
5. Inflammatory pathway spurs cancer stem cells to resist HER2-targeted breast cancer treatment
6. Killer infections targeted by hospital study
7. Lower risk of serious side-effects in trials of new targeted drugs
8. Treating drug resistant cancer through targeted inhibition of sphingosine kinase
9. New drug prevents spread of human prostate cancer cells
10. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
11. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2015)... DC (PRWEB) May 26, 2015 ... podiatrist Dr. Enzo J. Leone (Pasadena and ... service as the Maryland Podiatric Medical Association (MPMA) President ... , Dr. Leone received his Doctorate in Podiatric Medicine ... at the West Jersey Hospital in Voorhees, New Jersey. ...
(Date:5/26/2015)... May 26, 2015 Pacifica ... during the Memorial Day weekend, celebrating the outstanding ... on Pacifica’s picturesque Ladera Lane campus, located in ... and alumni traveled to Santa Barbara from all ... , The 2015 commencement ceremonies featured ...
(Date:5/26/2015)... Hanover, MA (PRWEB) May 26, 2015 ... the much acclaimed Boston Pops and their renowned Conductor ... wonderful event on Wednesday evening, June 10, 2015—the ... . , The Boston Pops Night is set to ... guest, Boston Pops Conductor Keith Lockhart who tragically lost ...
(Date:5/26/2015)... The professionals from Marietta Vet Clinic ... helping local rescue pets with a parking lot cookout ... Kimmerling DDS, Suzanna Aguilera DMD and Garrick McGrath DMD ... 100% of proceeds from the extravaganza. , Tents, grills ... to help save unwanted, local animals. Doctors and ...
(Date:5/26/2015)... NC (PRWEB) May 26, 2015 Carl ... at Pinehurst Surgical Center in Pinehurst, N.C. have launched ... sinus surgery patients about chronic sinusitis and the benefits ... that can be used to determine if someone is ... questions about symptoms and other factors that can contribute ...
Breaking Medicine News(10 mins):Health News:Foot and Ankle Specialists of the Mid-Atlantic, LLC Podiatrist Receives MPMA Service Award 2Health News:Pacifica Graduate Institute Hosted its 2015 Commencement Ceremonies over Memorial Day Weekend 2Health News:Pacifica Graduate Institute Hosted its 2015 Commencement Ceremonies over Memorial Day Weekend 3Health News:Boston Pops & Renowned Conductor Keith Lockhart to Join the Brain Aneurysm Foundation for the 4th Annual Brain Aneurysm Foundation Night at the Pops 2Health News:"Rescue Animal Cookout" Announced at Verde Pointe Professional Park on June 25, 2015 2Health News:Pinehurst Surgical Sinus Center Launches Pinehurst Balloon Sinuplasty Website 2
... French . The medicinal use of cannabis has ... large for many years as an alternative to standard pharmaceutical ... may have unwanted side effects. A new study by McGill ... that cannabis may offer relief to patients suffering from chronic ...
... cannabis reduces pain, improves mood and helps sleep, ... Medical Association Journal) (pre-embargo link only) http://www.cmaj.ca/embargo/cmaj091414.pdf ... pain due to damage or dysfunction of the ... include opioids, anticonvulsants, antidepressants and local anesthetics, but ...
... Amanda Gardner HealthDay Reporter , FRIDAY, Aug. 27 ... real and pervasive condition, new research suggests there is a ... either to get drugs or gain special privileges in school. ... to do a good job of faking on a number ...
... . , Montreal, August 27, 2010 While some ... scientists at the University of Toronto and the University of ... in some adolescents. Published in the journal Addictive Behaviors ... in Teens (NDIT) study based at the University of Montreal ...
... HealthDay Reporter , THURSDAY, Aug. 26 (HealthDay News) ... salmonella bacteria in feed given to chickens at the two ... finding, at Iowa-based Wright County Egg and Hillandale Farms, ... of the salmonella outbreak, government experts said at a press ...
... Traumatic brain injury, currently considered a singular event by ... instead the beginning of an ongoing process that impacts ... diseases and disorders that can reduce life expectancy, according ... at Galveston. As such, traumatic brain injury should ...
Cached Medicine News:Health News:Research demonstrates benefits of medical cannabis as a treatment for chronic pain 2Health News:Smoked cannabis reduces chronic pain 2Health News:Some Fake ADHD to Get Meds, Special Treatment 2Health News:Some Fake ADHD to Get Meds, Special Treatment 3Health News:Smoking increases depressive symptoms in teens 2Health News:Chicken Feed May Be Source of Salmonella in Egg Recall: FDA 2Health News:Chicken Feed May Be Source of Salmonella in Egg Recall: FDA 3Health News:Researchers urge reclassification of traumatic brain injury as chronic disease 2Health News:Researchers urge reclassification of traumatic brain injury as chronic disease 3Health News:Researchers urge reclassification of traumatic brain injury as chronic disease 4
(Date:5/22/2015)... Taskforce representing Canada,s living victims of ... the Minister and Health Canada have put into this program ... of the thalidomide survivors, and more than 70% of them ... annual adjustments for inflation. Certain of the thalidomide ... on the severity of their disability, tax free, with inflation ...
(Date:5/22/2015)... BOTHELL, Wash. , May 22, 2015  BioLife Solutions, ... marketer of proprietary clinical grade hypothermic storage and ... products for cells and tissues ("BioLife" or the "Company"), ... 2015 Marcum MicroCap Conference. The Company is ... on Wednesday, May 27, 2015 at the Grand Hyatt Hotel ...
(Date:5/22/2015)... 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX), a clinical-stage ... regeneration, today announced that J.J. Finkelstein , chief ... corporate overview at two upcoming investor conferences. ... th Annual Microcap Conference on Thursday May 28, ... at 11:00 am EDT.  A webcast will be available ...
Breaking Medicine Technology:BioLife Solutions To Present At The 2015 Marcum MicroCap Conference In New York City 2RegeneRx to Present at 2 Investor Conferences 2RegeneRx to Present at 2 Investor Conferences 3
... India, Oct. 10, 2011 Groupe Athena, Inc. (Pink sheets ... quarter ending September 30, 2011 which generated pretax earnings of ... for the same period. With the most recent strong quarter, ... share. The record quarterly revenue was significant in that it ...
... HILLS, N.J., Oct. 10, 2011 The New Jersey Patient ... in the Garden State, encourages men and their families to ... U.S. Preventive Services Task Force (USPSTF) recommended healthy men should ... of routine cancer screening. This decision was ...
Cached Medicine Technology:Groupe Athena, Inc. Reports Record First Quarter Revenues 2Groupe Athena, Inc. Reports Record First Quarter Revenues 3NJ Docs Say Cancer Detection Tool Saves Lives 2
ISI Ultra-Light Specialty Table offers the ultimate accessibility for surgeons, technicians and equipment during upper extremity surgeries....
MagaCell-Streptavidin is a streptavidin coupled to magnetizable cellulose/iron oxide particles...
... The BcMag Streptavidin magnetic beads ... capture of biotinylated molecules such ... protein from cell lysates or ... its highly dispersed, it can ...
... beads are 1 m ... to a form of ... be useful as ligands ... mRNA isolation and the ...
Medicine Products: