Navigation Links
Pitt: Targeted oxidation-blocker prevents secondary damage after traumatic brain injury
Date:8/26/2012

PITTSBURGH, Aug. 26, 2012 Treatment with an agent that blocks the oxidation of an important component of the mitochondrial membrane prevented the secondary damage of severe traumatic brain injury and preserved function that would otherwise have been impaired, according to a research team from the University of Pittsburgh School of Medicine, Graduate School of Public Health and Department of Chemistry in a report published online today in Nature Neuroscience.

Annually, an estimated 1.7 million Americans sustain a traumatic brain injury (TBI) due to traffic accidents, falls, assaults and sports participation, said the study's senior author Hlya Bayιr, M.D., associate professor, Department of Critical Care Medicine, University of Pittsburgh School of Medicine. She added that 52,000 of those injured die, and 85,000 are left with significant disability.

"We don't yet have a specific therapy for TBI, but can provide only supportive care to try to ease symptoms," Dr. Bayιr said. "Our study drug shows promise as a neuroprotective agent that might help address this important public health problem."

For the study, the research team conducted a global assessment of all the phospholipids in rat brain cells. This revealed that damage from TBI was nonrandom and mostly involved cardiolipin, a phospholipid that is found in the membranes that form mitochondria, the cell's powerhouse. They noted that in the healthy animal, only 10 of the 190 cardiolipin species were modified by oxygen, but after a brain injury, the number of oxidized species rose many-fold.

The researchers then developed an agent, called XJB-5-131, which can cross the blood-brain barrier and prevent the oxidation of cardiolipin. Using an established research model of severe TBI, the agent or a placebo was injected into the bloodstream of rats five minutes and again 24 hours after head injury.

In the weeks that followed, treated animals performed a
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Targeted therapeutics for colon cancer to be presented at AACR meeting
2. First targeted nanomedicine to enter human clinical studies
3. Highly targeted irradiation as good as whole breast radiotherapy in early stage cancer
4. Dana-Farber: Study reports first success of targeted therapy in type of non-small cell lung cancer
5. Inflammatory pathway spurs cancer stem cells to resist HER2-targeted breast cancer treatment
6. Killer infections targeted by hospital study
7. Lower risk of serious side-effects in trials of new targeted drugs
8. Treating drug resistant cancer through targeted inhibition of sphingosine kinase
9. New drug prevents spread of human prostate cancer cells
10. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
11. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... Hills, CA (PRWEB) July 23, 2014 ... 90 million Americans suffering from chronic bad breath that the ... whom they speak. , Dr. Saj Jivraj and Dr. Mamaly ... Woodland Hills, Calif., are concerned that some people may be ... breath often is a sign of an infection or chronic ...
(Date:7/23/2014)... QueenBeeTickets.com is reducing the prices of History of The Eagles ... who are still in the process of looking for concert ... use promo code “DISCOUNT” to get even lower prices than ... of discounted tickets at QueenBeeTickets.com. , The phenomenal band will ... The Eagles concert tickets literally disappearing across the country. The ...
(Date:7/23/2014)... 23, 2014 There is inherently nothing ... that it is healthy enough to react to specific ... “washing out” harmful toxins and bacteria from the body ... body just cannot do. , However, the social ... commonly known as “excessive sweating”—are serious: since sweating itself ...
(Date:7/23/2014)... Online medical service provider MeMD has appointed Dr. ... Dr. Lorenzo joins the MeMD executive team with over 25 ... part of this remote treatment model, telemedicine. This is the ... medical school, that someday we could treat people across the ... and it hasn't been that long,” says Dr. Lorenzo. , ...
(Date:7/23/2014)... viewed with suspicion as a New Age indulgence or ... business and arguably the most successful segment of health ... Die , award-winning journalists Fran Smith and Sheila Himmel ... their families. It’s the first book to take a ... of patients, caregivers and cutting-edge researchers, as well as ...
Breaking Medicine News(10 mins):Health News:Woodland Hills’ Top Cosmetic Dentists Offer 6 Tips on Causes of Bad Breath That Should Concern You 2Health News:Woodland Hills’ Top Cosmetic Dentists Offer 6 Tips on Causes of Bad Breath That Should Concern You 3Health News:Woodland Hills’ Top Cosmetic Dentists Offer 6 Tips on Causes of Bad Breath That Should Concern You 4Health News:Woodland Hills’ Top Cosmetic Dentists Offer 6 Tips on Causes of Bad Breath That Should Concern You 5Health News:History of The Eagles Tour Tickets: QueenBeeTickets.com Reduces Prices on Remaining Inventory of Concert Tickets for 2014 Shows 2Health News:Beat Your Sweating Demons Review | The Problem With Excessive Sweating and Solving it Naturally – Vinamy.com 2Health News:Beat Your Sweating Demons Review | The Problem With Excessive Sweating and Solving it Naturally – Vinamy.com 3Health News:Telemedicine Provider MeMD Announces Nicholas Lorenzo, MD, MHCM, CPE as Chief Medical Officer 2Health News:Telemedicine Provider MeMD Announces Nicholas Lorenzo, MD, MHCM, CPE as Chief Medical Officer 3Health News:Dealing with Loss: Library Journal Calls Changing the Way We Die an Essential Read 2
... hit Western Australia's south region with 50 cases being reported ... has also been // reported in the Territories with another ... ,Entomologist Nina Kurucz said that the pre-monsoon rains have ... is that this sort of mosquito can fly up to ...
... Professor Robin Simon and colleagues from Florida State University ... Behavior the reports of their study// conducted in ... had plans of not having children’s experienced less depression ... claims controversies views expressed by earlier researchers who had ...
... determining mental health status of an individual according to ... fatty food and compromise on fresh food such as ... memory related problems. Moreover, implementation of diet changes was ... than conventional approaches such as drug treatment or counseling. ...
... to treat breast cancer reduces the radiation time from six weeks ... it is less convenient. Doctors// can point the radiation ... study compares the usefulness of the new therapy over the conventional ... suitable subjects for this therapy. ,But the Canadians are ...
... a workshop on Islamic Medical Ethics new rules and ... was attended by national and international physicians who wanted ... Malika Haque, Clinical Professor Pediatrics, Ohio State University and ... several new ethical laws. ,They said ...
... Jong S. Kim and his colleagues from Asan medical ... drug Prozac is found effective in treating emotional stress ... conducted their study in 152 patients who were given ... months and the results found that the study patients ...
Cached Medicine News:Health News:Diet Can Influence Your Mental Health As Well 2
(Date:7/22/2014)... , July 22, 2014 The National Space ... the Center for Space Radiation Research (CSRR) under the ... is an Associate Professor of Pharmaceutical Sciences within the ... Pharmacy Division of Radiation Health. She is located in ... direct a team of investigators working across four U.S. ...
(Date:7/22/2014)... 22, 2014  Decision Resources Group finds that ... patients currently treated with Biogen Idec,s oral ... flushing and/or gastrointestinal events while on the ... experiencing these side effects, signifying either their ... of such events. In the end, fewer ...
(Date:7/22/2014)... , July 22, 2014  Eyeon Therapeutics has ... eye treatment based on a charged hydrophilic polymer developed ... product has been shown to be safe and effective ... , MD, CEO states, "This first set of claims ... long way to moving this technology into the commercial ...
Breaking Medicine Technology:Boerma Led UAMS Team to Establish NSBRI's Center for Space Radiation Research (CSRR) 2Boerma Led UAMS Team to Establish NSBRI's Center for Space Radiation Research (CSRR) 3Over Half of Audited Multiple Sclerosis Patients Currently Treated with Biogen Idec's Tecfidera Have Experienced Minor Side Effects Although Impact on Use Appears Muted 2Over Half of Audited Multiple Sclerosis Patients Currently Treated with Biogen Idec's Tecfidera Have Experienced Minor Side Effects Although Impact on Use Appears Muted 3Particle Sciences and Eyeon Therapeutics Receive Patent on Novel Dry Eye Technology 2
... - Fralex Therapeutics Inc.,(TSX:FXI) ("Fralex" or the "Company"), ... today provided an update,on receiving results of the ... is investigating the use of Complex Neural Pulse ... associated with fibromyalgia., The Independent Data Monitoring ...
... from a 52-week phase 3,study (LEADTM 3) of ... once-daily,human GLP-1 analog, were published online today in ... alone, produces statistically,significant and sustained improvements in blood ... as compared with glimepiride, a widely used,oral anti-diabetic ...
Cached Medicine Technology:Fralex provides update on timing of interim analysis results 2Data from One-Year Liraglutide Phase 3 Study Published Online in The Lancet 2Data from One-Year Liraglutide Phase 3 Study Published Online in The Lancet 3
Velcro closures on each side to more evenly distribute the weight. Available in teal, royal, red, purple, or maroon nylon stain-resistant fabric or navy nylon reinforced vinyl....
Our quick release buckle apron is user friendly and our large support straps criss-crossing the back allows proper placement of the belt at your waist. Built-in shoulder pads add to the comfort....
An economical solution to the need to provide wrap-around protection. The one-sided velcro closure allows greater flexibility in sizing. Front protection is 0.5mm Pb and the back is 0.25mm Pb equival...
The most comfortable and easy to use apron in the industry. This front protection apron comes with a fully adjustable snap-on 5" orthopedic belt to relieve weight off your shoulders. Velcro strap acr...
Medicine Products: