Navigation Links
Pitt: Targeted oxidation-blocker prevents secondary damage after traumatic brain injury
Date:8/26/2012

PITTSBURGH, Aug. 26, 2012 Treatment with an agent that blocks the oxidation of an important component of the mitochondrial membrane prevented the secondary damage of severe traumatic brain injury and preserved function that would otherwise have been impaired, according to a research team from the University of Pittsburgh School of Medicine, Graduate School of Public Health and Department of Chemistry in a report published online today in Nature Neuroscience.

Annually, an estimated 1.7 million Americans sustain a traumatic brain injury (TBI) due to traffic accidents, falls, assaults and sports participation, said the study's senior author Hlya Bayιr, M.D., associate professor, Department of Critical Care Medicine, University of Pittsburgh School of Medicine. She added that 52,000 of those injured die, and 85,000 are left with significant disability.

"We don't yet have a specific therapy for TBI, but can provide only supportive care to try to ease symptoms," Dr. Bayιr said. "Our study drug shows promise as a neuroprotective agent that might help address this important public health problem."

For the study, the research team conducted a global assessment of all the phospholipids in rat brain cells. This revealed that damage from TBI was nonrandom and mostly involved cardiolipin, a phospholipid that is found in the membranes that form mitochondria, the cell's powerhouse. They noted that in the healthy animal, only 10 of the 190 cardiolipin species were modified by oxygen, but after a brain injury, the number of oxidized species rose many-fold.

The researchers then developed an agent, called XJB-5-131, which can cross the blood-brain barrier and prevent the oxidation of cardiolipin. Using an established research model of severe TBI, the agent or a placebo was injected into the bloodstream of rats five minutes and again 24 hours after head injury.

In the weeks that followed, treated animals performed akin to normal on tests of balance, agility and motor coordination, learning, and object recognition, while placebo-treated animals showed significant impairment. The results indicate that blocking cardiolipin oxidation by XJB-5-131 protected the brain from cell death.

"The primary head injury might not be that serious," Dr. Bayιr noted. "But that initial injury can set into motion secondary cellular and molecular events that cause more damage to the brain and that ultimately determine the outcome for the patient."

She added that a targeted oxidation-blocker might also be beneficial in the treatment of other neurological disorders, such as Parkinson's disease, amyotrophic lateral sclerosis, or ALS, and stroke.


'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Related medicine news :

1. Targeted therapeutics for colon cancer to be presented at AACR meeting
2. First targeted nanomedicine to enter human clinical studies
3. Highly targeted irradiation as good as whole breast radiotherapy in early stage cancer
4. Dana-Farber: Study reports first success of targeted therapy in type of non-small cell lung cancer
5. Inflammatory pathway spurs cancer stem cells to resist HER2-targeted breast cancer treatment
6. Killer infections targeted by hospital study
7. Lower risk of serious side-effects in trials of new targeted drugs
8. Treating drug resistant cancer through targeted inhibition of sphingosine kinase
9. New drug prevents spread of human prostate cancer cells
10. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
11. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... Forty-five percent of American respondents ... family members or friends have also commented about their poor hearing. However, only ... aids. One reason, suggested by 89 percent of American respondents, is that they ...
(Date:2/22/2017)... Isle, North Carolina (PRWEB) , ... February 22, 2017 , ... ... 59% of cats and 54% of dogs, according to the Association for Pet Obesity ... professionals disagreed on key pet food issues such as the benefits of corn and ...
(Date:2/22/2017)... , ... February 22, 2017 , ... BrightStar Care ... sponsors of the Medical University of South Carolina (MUSC) Center on Aging’s Senior ... SC. “MUSC’s Center on Aging is a tremendous resource in our community. We are ...
(Date:2/22/2017)... ... February 22, 2017 , ... Alto-Shaam is pleased to ... Multi-Cook Oven offers up to four ovens in one. Control temperature, fan speed ... unmatched evenness in cooking. Alto-Shaam has partnered with Appliance Innovation to introduce this ...
(Date:2/21/2017)... ... February 22, 2017 , ... Author Michèle Wolff has a ... every household and family to know all about it for optimal health. Wanting to ... release of “ Detox, Digestive and Wellness Solutions ” (published by Balboa Press AU). ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... , Feb. 22, 2017   Protein Sciences Corporation ... Flublok® Influenza Vaccine , announced today that they ... Influenza Vaccine Introduction (PIVI) and the Mongolian Ministry of ... of the flu.  The doses of Flublok have been ... Mongolia for health care workers, pregnant women, ...
(Date:2/22/2017)... 22, 2017 The Senior Care Pharmacy Coalition ... and House of Representatives that will curtail the ability ... -- from extracting retroactive direct and indirect remuneration (DIR) ... pharmacies and the Medicare program. S. 413, ... and Jon Tester (D-MT), and House companion ...
(Date:2/22/2017)... , Feb 22, 2017 Research ... Temperature Monitoring Devices Market (Thermometers - Digital, Infrared, Mercury; Trend Indicator):Analysis ... ... Monitoring Devices Market is forecasted to grow at a CAGR of ... the rising prevalence of infectious diseases along with surging demand of ...
Breaking Medicine Technology: