Navigation Links
Pitt, Wake Forest team finds why stored transfusion blood may become less safe with age
Date:7/13/2011

PITTSBURGH, July 13 Transfused blood may need to be stored in a different way to prevent the breakdown of red blood cells that can lead to complications including infection, organ failure and death, say researchers at the University of Pittsburgh School of Medicine and Wake Forest University. This week in the early online version of Circulation, the team reports the latest findings from its ongoing exploration of the interaction between red blood cell breakdown products and nitric oxide (NO), revealing new biological mechanisms that can reduce blood flow and possibly damage vital tissues after administration of blood that has been stored for longer than 39 days.

In recent years, doctors have noted that transfusion of either many units of blood or of blood stored a long time may be associated with a greater frequency of complications, such as increased infection risk, kidney, lung or multi-organ failure and death, particularly among medically vulnerable patients, explained senior investigator Mark T. Gladwin, M.D., chief, Division of Pulmonary, Allergy and Critical Care Medicine, Pitt School of Medicine, and director of Pitt's Vascular Medicine Institute.

"When blood sits for a while, some of the cells break down and release their contents, which include molecules of hemoglobin and red blood cell microparticles," he said. "These accumulate in the stored bag of blood and are transfused into the patient with the blood. In the bloodstream, the hemoglobin and microparticles bind to and destroy NO, a very important molecule that is used by the body to keep blood vessels dilated for normal blood flow."

The scavenging of NO causes blood vessel constriction that can prevent tissues and organs from getting adequate oxygen and activate the platelets and the coagulation system, as well as cause inflammation, Dr. Gladwin said.

From their experiments, he and his Wake Forest collaborators found that human blood stored under standar
'/>"/>

Contact: Anita Srikameswaran
SrikamAV@upmc.edu
412-578-9193
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Wake Forest Baptist conducts clinical study for insomnia using new technology
2. Researchers warn of fever from the forest
3. The same type of forest is good for both birds and people
4. Cocaine production increases destruction of Colombias rainforests
5. Exercise can forestall osteoporosis
6. Woodmeister Master Builders Announces Commitment to Preserve One Foot of Forest for Each Foot it Builds
7. Forest City Announces Joint Venture with Health Care REIT for University Park Life Science Properties
8. Pivotal study in Africa finds that HIV medications prevent HIV infection
9. Severity of spinal cord injury has no impact on how adults rate their health, WSU research finds
10. First-ever review finds smoking causes serious birth defects
11. Pew finds serious gaps in oversight of US drug safety
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... Washington, DC (PRWEB) May 04, 2015 ... of Kit Check as a finalist for the EY ... Washington Region. The awards program recognizes entrepreneurs who ... innovation, financial performance and personal commitment to their businesses ... finalist by a panel of independent judges. Award ...
(Date:5/4/2015)... Ticket Down is a reputable source for ... in Columbia, South Carolina. Fans of Paul McCartney ... There” tour which originally kicked off in 2013. The most ... and the legendary performer recently announced that he would be ... on June 21st, in Charlottesville, VA at John Paul Jones ...
(Date:5/4/2015)... San Diego Fertility Center (SDFC) ... new, 13,700 square foot facility scheduled to open in ... only provide fertility treatment and services for the center’s ... educational events to a number of local and international ... to their current Carmel Valley/Del Mar location and will ...
(Date:5/4/2015)... Rafael, CA (PRWEB) May 04, 2015 Unlike some ... foremost on imparting knowledge. The goal is to educate first ... the classroom. This ensures that the young runners are building ... careers. A few of the topics covered include Effort Based ... fast as I used to be? This is not a ...
(Date:5/4/2015)... May 04, 2015 Sylvia Hawthorn-Deppen shared her ... that it would remind others in similar situations that they ... from Chronic Pain and Discovery of New Energy” (published by ... new audience via a renewed press campaign. , “I have ... debilitating pain ,” Hawthorn-Deppen says. “As an adolescent I got ...
Breaking Medicine News(10 mins):Health News:EY announces Kit Check CEO and Co-founder Kevin MacDonald as an EY Entrepreneur Of The Year® 2015 Award finalist in the Greater Washington Region 2Health News:Paul McCartney Tickets at Colonial Life Arena in Columbia, SC: Ticket Down Slashes Paul McCartney Ticket Prices in Columbia, South Carolina at Colonial Life Arena 2Health News:San Diego Fertility Center Hosted a Ribbon Cutting Ceremony at Its New, Expanded Facility 2Health News:San Diego Fertility Center Hosted a Ribbon Cutting Ceremony at Its New, Expanded Facility 3Health News:US Sports Camps and Select Nike Running Camps Offer Programs for Middle School Runners 2Health News:Author launches new press campaign for 2012 book ‘Wheel’ 2
... Nov. 21 Attorneys representing consumers and,third-party payers ... healthcare services giant McKesson (NYSE: MCK ... price of more than 400 prescription drugs by,manipulating ... (Logo: http://www.newscom.com/cgi-bin/prnh/20080317/AQM144LOGO ) , ...
... 21 DATATRAK,International, Inc. (Nasdaq: DATA ... eClinical solutions for the clinical trials industry, today ... Corporation, has placed its first,self-designed project using the ... trial. The successful rollout of this first,independently ...
... VICL ) today announced a strategic restructuring ... the company,s total workforce,and accelerated closure of a research ... employees and expects to reduce future,net losses and cash ... The restructuring is designed to ...
... to a relationship between erectile dysfunction and prostate enlargement. Because of ... to increase the treatment of BPH in men. The focus of ... (ED). Dr. Eid will continue with ED treatments while building his ... ...
... prestigious "Super Dentist" award given to elite dentists in Texas. Dr. ... in the area of Cosmetic Dentistry. , ... Austin, ... Smiles was recently nominated as a "Texas Monthly Super Dentist" ...
... that timing is everything, and that certainly appears to be ... before the height of cold and flu season have a ... any other time of year, according to new research. ... more than 95,000 children and their mothers in Tennessee to ...
Cached Medicine News:Health News:Hagens Berman Sobol Shapiro: McKesson Settles RICO Lawsuit for $350 Million 2Health News:Hagens Berman Sobol Shapiro: McKesson Settles RICO Lawsuit for $350 Million 3Health News:NTT DATA Launches First Self-Designed DATATRAK eClinical(TM) Project Into Production in Japan 2Health News:NTT DATA Launches First Self-Designed DATATRAK eClinical(TM) Project Into Production in Japan 3Health News:Vical Announces Strategic Restructuring and Staff Reduction 2Health News:Vical Announces Strategic Restructuring and Staff Reduction 3Health News:World-Renowned Urologist, J. Francois Eid, M.D., Expands Practice with Increased Treatment of Benign Prostate Hyperplasia (BPH) 2Health News:World-Renowned Urologist, J. Francois Eid, M.D., Expands Practice with Increased Treatment of Benign Prostate Hyperplasia (BPH) 3Health News:World-Renowned Urologist, J. Francois Eid, M.D., Expands Practice with Increased Treatment of Benign Prostate Hyperplasia (BPH) 4Health News:Texas Super Dentist Awards Announced--Dr. Michael McCarty From Austin Smiles Is Awarded For The Third Year In A Row 2Health News:Fall babies: Born to wheeze? 2
(Date:5/4/2015)... DIEGO , May 4, 2015 ... oncology company focused on the clinical development of ... data showing mitochondria-specific effects of the Company,s investigational ... enhanced anti-tumor activity when combined with a tyrosine-kinase ... found ME-344 to be a potent inhibitor of ...
(Date:5/4/2015)... the cuvette manufacturing world, opened their doors to the public in early 2015.  In ... scientists amazing support for their spectroscopy needs.  ... ... ... In mid-2014 Simcha Woitovich ...
(Date:5/4/2015)... May 4, 2015 Dyadic International, Inc. ... patented and proprietary technologies are used to develop, ... the bioenergy, bio-based chemical, biopharmaceutical and industrial enzyme ... financial results for quarter ending March 31, 2015 ... and will host a conference call that day ...
Breaking Medicine Technology:MEI Pharma's Mitochondrial Inhibitor ME-344 Shows Enhanced Anti-Tumor Activity in Combination with Tyrosine-Kinase Inhibitor in Pre-Clinical Studies 2MEI Pharma's Mitochondrial Inhibitor ME-344 Shows Enhanced Anti-Tumor Activity in Combination with Tyrosine-Kinase Inhibitor in Pre-Clinical Studies 3MEI Pharma's Mitochondrial Inhibitor ME-344 Shows Enhanced Anti-Tumor Activity in Combination with Tyrosine-Kinase Inhibitor in Pre-Clinical Studies 4MEI Pharma's Mitochondrial Inhibitor ME-344 Shows Enhanced Anti-Tumor Activity in Combination with Tyrosine-Kinase Inhibitor in Pre-Clinical Studies 5New Cuvette Manufacturer Delivers Fast, Easy Solutions for Even the Hardest Cuvette Experiments 2New Cuvette Manufacturer Delivers Fast, Easy Solutions for Even the Hardest Cuvette Experiments 3Dyadic International To Announce First Quarter 2015 Financial Results and Host Conference Call On Thursday, May 14, 2015 2Dyadic International To Announce First Quarter 2015 Financial Results and Host Conference Call On Thursday, May 14, 2015 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: