Navigation Links
Pioglitazone lowers cardiovascular risk in diabetic patients with kidney disease
Date:12/12/2007

Washington, DC (Wednesday, December 12, 2007) A new study confirms that chronic kidney disease (CKD) increases the already-high risk of serious cardiovascular events in diabetic patients with damage to the large blood vessels and suggests that treatment with the anti-diabetic drug pioglitazone may help to lower this risk, reports the January Journal of the American Society of Nephrology.

"The data confirm that chronic kidney disease is an independent risk factor for major adverse cardiovascular events and death, even amongst a very high-risk population of patients with diabetes and pre-existing macrovascular disease," comments Dr. Christian A. Schneider of University of Cologne, Germany. "In these patients with moderate to severe renal disease, pioglitazone reduced all-cause death, myocardial infarction, and stroke, independently of renal function."

The study was based on data from PROactive, a large-scale study of over 5,000 patients with type 2 diabetes who were at high cardiovascular risk because of macrovascular complications of diabetes. ("Macrovascular" disease means damage to the large blood vessels, such as the coronary arteries and the arteries supplying the legs.) In PROactive, patients were randomly assigned to treatment with the anti-diabetic drug pioglitazone or an inactive placebo.

Dr. Schneider and colleagues focused on 597 patients who had moderate to severe CKD in addition to diabetes and macrovascular disease. "It is well known that patients with diabetes and CKD are at particularly high risk for cardiovascular disease," Dr Schneider explains. "However, the impact of CKD on recurrent cardiovascular events among patients with diabetes and established macrovascular disease has not been studied previously." The CKD patients treated with pioglitazone versus placebo were compared for their rates of death or cardiovascular disease events, such as myocardial infarction (heart attack) and stroke.

Overall, 27.
'/>"/>

Contact: Shari Leventhal
sleventhal@asn-online.org
202-416-0658
American Society of Nephrology
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Takeda Statement on ACTOS(R) (Pioglitazone HCl) Meta-Analysis Published in the Journal of the American Medical Association
2. Specific antagonism lowers blood pressure
3. Drug That Lowers Resting Heart Rate Being Tested
4. Once-a-Year Bone Drug Lowers Fracture Risk
5. VIDEO from Medialink and the Flower Promotion Organization: A Cup of Coffee and Fresh Cut Flowers to Start the Day
6. Abbotts Investigational SIMCOR(R) Offers Comparable LDL Lowering to Simvastatin and Significantly Raises HDL and Lowers Triglycerides in Phase III Study
7. Sticking With Meds Lowers Elderly Fracture Risk
8. Fitness Sensation Susan Powter Returns to Her Legions of Fans and Followers with Focus on Whole Body Wellness Program
9. Participation in organized high school activities lowers risk of smoking 3 years after graduation
10. Antioxidants show no clear benefit against cardiovascular events, death in high-risk women
11. Waist-to-hip ratio may better predict cardiovascular risk than body mass index
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2008)...PRNewswire-FirstCall/ -- Aflac Incorporated,(NYSE:...nalyst meeting that,will be conducted in Tokyo, Ja...ales force will discuss the company,s operations i... 7, 2008, 8:00 p.m. - 2:30 a.m. United States EDT ...ime) Introductions, Kenneth S. Janke Jr. - Senio...
(Date:8/29/2008)...RNewswire/ -- Conseco Insurance Company, a life,an...ailability of its new,indexed universal life insu...ides upside potential with downside protection., ...licy that offers the,opportunity for long-term cas...f 1%. Clients can customize their coverage levels ...
(Date:8/29/2008)...d that Obama failed to address the issue, DENVER,...e Democratic,National Convention Wednesday night, ...orated response to the domestic HIV/AIDS epidemic ...inee Barack Obama, Clinton said,"He will continue...rship in,an area in which I am deeply involved: th...
(Date:8/29/2008)...romosomal change that raises odds for malignancy, ...ay News) -- Some Japanese survivors of the World W... experienced key genetic changes that may have spa...search indicates. , Papillary thyroid cancer (P...tation involving the so-called BRAF gene. But Japa...
Breaking Medicine News(10 mins):Health News:Aflac Incorporated to Webcast Tokyo Analysts Meeting 2Health News:Aflac Incorporated to Webcast Tokyo Analysts Meeting 3Health News:ConsecoLifeOptions Launched by Conseco Insurance Company as New Universal Life Product 2Health News:Bill Clinton and Other Leaders Call For 'Renewal of Battle Against AIDS' in the United States at Democratic Convention 2Health News:Bill Clinton and Other Leaders Call For 'Renewal of Battle Against AIDS' in the United States at Democratic Convention 3Health News:Some Hiroshima Survivors at Thyroid Cancer Risk 2Health News:Some Hiroshima Survivors at Thyroid Cancer Risk 3
...Department of Labor some of the hottest careers li...s field abound for men and women alike.// Those w... to become a medical assistant via accelerated voc...ommunity Colleges,or other career training institu...
...are coming forward to seek counseling and undergo ...ures, the Department of Health has reported.// It... utilized the screening services since 2000, thank...s encouraged people to ascertain their status. In ...
...stralia has decided to include Gardasil in the nat...g is effective for treating cervical cancer. The//...hools from April, 2007. All girls, between the age...ogram. All women between the ages of 18 and 26 wil...
...yball team lost to Chinese Taipei (Taiwan) in a qu...hree of its players were confirmed to have chicken...Taiwan 0-3," the Asian Volleyball Confederation (A..."Five players of Maldives have showed symptoms of ...
Other Medicine News:Health News:Guiding Students Toward a Successful Medical Assistant Career 2Health News:Guiding Students Toward a Successful Medical Assistant Career 3Health News:Maldives Volleyball Team Members Affected by Chickenpox 2
(Date:8/25/2008)... --May Lead to New Prevention and Treatment Strate...ire/ -- Scientists have,discovered gene mutations ...f the childhood cancer neuroblastoma. In addition,...y a significant role in high-risk forms of,non-inh...disease., "This discovery enables us to offer the...
(Date:8/25/2008)...ront Line CLL, NHL and CLL Retreatment and Japanes... Planned, COPENHAGEN, Denmark, August 25 /PRNew...begin four studies of ofatumumab in chronic lympho...b A/S (OMX: GEN) announced today plans to begin fo...ukemia (CLL) and follicular,non-Hodgkin,s lymphoma...
(Date:8/21/2008)... Flu Vaccination Awareness Campaign Addresses Know...esident is Not the Only Important Choice to ...G, Md., Aug. 21 /- A new survey of pa...ion ranks next to last among,things they believe t...irus. Although public health guidelines state that...
(Date:8/21/2008)...lex,s ImmuKnow(R) assay suggests clinical potentia...c liver transplant patients, COLUMBIA, Md., Aug. ...just published in the peer-reviewed journal Liver ...tanding of the clinical potential of monitoring,ce...t patients,post-transplantation., Working in a co...
Breaking Medicine Technology:Gene That Causes Childhood Cancer Neuroblastoma Is Found 2Gene That Causes Childhood Cancer Neuroblastoma Is Found 3Gene That Causes Childhood Cancer Neuroblastoma Is Found 4Genmab Announces Upcoming Ofatumumab Studies 2Genmab Announces Upcoming Ofatumumab Studies 3Genmab Announces Upcoming Ofatumumab Studies 4Survey Shows Parents' Best Intentions Out of Step with Expert Recommendations in Protecting Kids from Flu 2Survey Shows Parents' Best Intentions Out of Step with Expert Recommendations in Protecting Kids from Flu 3Survey Shows Parents' Best Intentions Out of Step with Expert Recommendations in Protecting Kids from Flu 4Survey Shows Parents' Best Intentions Out of Step with Expert Recommendations in Protecting Kids from Flu 5New Data Support Earlier Suggested Guidance for Levels of Cell-Mediated Immunity in Pediatric Liver Transplant Patients 2New Data Support Earlier Suggested Guidance for Levels of Cell-Mediated Immunity in Pediatric Liver Transplant Patients 3Sideline Rage Triggers Mirror Those of Angry Drivers 23321 1Sideline Rage Triggers Mirror Those of Angry Drivers 23321 2Mesa Laboratories Inc Added to the Russell Microcap Index 23316 1Mesa Laboratories Inc Added to the Russell Microcap Index 23316 2Senesco Technologies Closes Remaining 243 0 Million of Previously Announced Financing 6390 1Senesco Technologies Closes Remaining 243 0 Million of Previously Announced Financing 6390 2Senesco Technologies Closes Remaining 243 0 Million of Previously Announced Financing 6390 3Geisinger study 3A PTSD causes early death from heart disease 23311 1
...n Contaminated with Diethylene Glycol,(DEG) Remain...VILLE, Md., May 4, 2007-The U.S. Food and Drug,Adm...cturers,suppliers, drug repackers, and health pro...ly vigilant in assuring that glycerin, a,sweetener...r and,prescription drug products, is not contamina...
...LE, Md., April 25, 2007-The U.S. Food and Drug,Adm... Decree of,Permanent Injunction against PharmaFab ...icials, Mark Tengler, PharmaFab,s president,and R...ffairs, to,stop the illegal manufacture and distri...roducts. The products are illegal because,they are...
Other Medicine Technology:FDA Advises Manufacturers to Test Glycerin for Possible,Contamination 2Major Manufacturer of Unapproved and Adulterated Drugs 2Major Manufacturer of Unapproved and Adulterated Drugs 3
... national reference laboratory and a worldwide lea...ent. ARUP offers an extensive test menu of highly ...natomic pathology. Owned by the University of Utah...f of the nation's university teaching hospitals an...
... national reference laboratory and a worldwide lea...ent. ARUP offers an extensive test menu of highly ...natomic pathology. Owned by the University of Utah...f of the nation's university teaching hospitals an...
... national reference laboratory and a worldwide lea...ent. ARUP offers an extensive test menu of highly ...natomic pathology. Owned by the University of Utah...f of the nation's university teaching hospitals an...
... national reference laboratory and a worldwide lea...ent. ARUP offers an extensive test menu of highly ...natomic pathology. Owned by the University of Utah...f of the nation's university teaching hospitals an...
Medicine Products: