Navigation Links
Pint-size microRNAs show promise against weighty problem, researchers say
Date:9/6/2012

Tiny strands of RNA affect how our cells burn fat and sugar a finding that gives biologists a place to start in the quest for therapies to treat obesity and related health problems, said scientists at Virginia Tech and the University of Texas Southwestern Medical Center at Dallas.

Mice on high fat diets are resistant to obesity when two mini-molecules called microRNAS are missing from their genetic makeup, according to a study this week in the Proceedings of the National Academy of Science

The discovery suggests that treatments targeting these two specific microRNAs may help stem the nation's obesity epidemic. More than one-third of adults in the United States and about 17 percent of the nation's children are obese, increasing their risk for type 2 diabetes, heart disease, stroke, liver disease, and some cancers, according to the National Institutes of Health.

"Scientists know the best health solution for obesity involves eating less and exercising more," said Matthew W. Hulver, Ph.D., an associate professor with the Department of Human Nutrition, Foods, and Exercise in the College of Agriculture and Life Sciences at Virginia Tech. "But in cases when people can't or won't exercise, if we can identify what is contributing to the regulation of our metabolic circuits, we can target it with a drug or pharmacologic solution."

Once considered to be little more than scrap DNA, scientists now know microRNAs have an important role in regulating how genes shape human health and behavior. They have been linked to heart disease, diabetes, hepatitis C, leukemia, lymphoma, and breast cancer.

Although microRNAs previously have been linked to obesity, the new findings are the first to establish a connection between microRNAs and cellular metabolism.

MicroRNA biologists at UT Southwestern Medical Center modified mice to be genetically unable to produce microRNA-378 and its cousin miR-378*, resulting in relatively trim anima
'/>"/>

Contact: John Pastor
jdpastor@vt.edu
540-231-5646
Virginia Tech
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Alzheimers Drug Shows Some Promise in Trials
2. Rewired visual input to sound-processing part of the brain leads to compromised hearing
3. Green tea compound shows promise for tackling cancer
4. Male Birth Control Drug Shows Promise in Mice
5. Therapy combining exercise and neuroprotective agent shows promise for stroke victims
6. In Mice, Alzheimers-Linked Protein Shows Promise Against MS
7. Stem Cells Show Promise as Heart Failure Treatment
8. Alzheimers Drug Shows Promise in Early Trial
9. A nursing program shows promise for reducing deaths from chronic illnesses
10. Alzheimers Treatment Shows Promise in Small, 3-Year Trial
11. New gene transfer strategy shows promise for limb girdle and other muscular dystrophies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... today in PLOS Pathogens , children who live ... can mount an immune response to infection with malaria ... of high fever and illness and partially control the ... may help researchers develop future interventions that prevent or ... Each year, approximately 200 million cases of malaria occur ...
(Date:4/17/2014)... Diego School of Medicine report that older women, plucky ... loss are more likely to be compassionate toward strangers ... in this month,s issue of the International Journal ... associated with better health and well-being as we age, ... the outcomes of individuals whose deficits in compassion put ...
(Date:4/17/2014)... a review published in the April issue of ... Feinstein Institute for Medical Research, says it,s time to ... approach to treating sepsis, which kills millions worldwide ... occurs when molecules released into the bloodstream to fight ... Inflammation is necessary for maintaining good health without ...
(Date:4/17/2014)... Northwestern University synthetic biology team has created a ... programmable therapeutics that could travel the body and ... , Engineering cell-based, biological devices that monitor and ... clinical synthetic biology. However, no existing technology enabled ... patient,s physiological state and respond in a customized ...
(Date:4/17/2014)... MAYWOOD, Il. (April 17, 2014) Doctors who ... disease called lymphangioleiomyomatosis (LAM) can face an agonizing ... progression of the disease and help relieve shortness ... lung transplants, and sirolimus can cause potentially fatal ... said pulmonologist Dr. Daniel Dilling, medical director of ...
Breaking Medicine News(10 mins):Health News:Study sheds light on how the immune system protects children from malaria 2Health News:The ilk of human kindness 2Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Building 'smart' cell-based therapies 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3
... Companies Will Discuss Recent FDA Advisory Regarding Byetta, ... LLY ) and Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN ... 2008 at 5:00 p.m. EDT to discuss the,recent FDA ... Lilly will be Donald Therasse, M.D., vice president of ...
... they spend billions out of pocket for what they do ... -- Uninsured Americans will spend $30 billion out of pocket ... in 2008, new research shows. , Uncompensated care is ... for by the uninsured or a health insurer. , In ...
... center for Tuesday, August 26, between 2:00 - 2:30 ... abortion., Two Catholic Priests, one Evangelical Pastor among ... Rescue Founder says:, "Obama,s pick of Biden is ... betrayal of his Faith will help mobilize Catholic,clergy and ...
... say bloodletting is the best available option for people ... -- Bloodletting is often dismissed as a primitive form ... the body of bad humors by draining the life-sustaining ... where bloodletting is still the preferred means of treatment. ...
... 25 Borrowing and sharing of,prescription medications is ... of nearly 7,500 women of reproductive age found ... of this population, according to a,report published online ... a,peer-reviewed journal published by Mary Ann Liebert, Inc. ...
... The U.S. Pharmacopeial (USP) Convention today announces a new ... physicians and others in avoiding medication errors that may ... sound alike. This "Drug Error Finder" is a searchable ... be involved in medication mix-ups in the U.S. health ...
Cached Medicine News:Health News:Lilly and Amylin Set Date and Time for Conference Call 2Health News:Uninsured Get Less Health Care Than Insured 2Health News:DNC 'Party Crashers:' Police Arrest 1 Pro-lifer at Black Caucus; Eject Operation Rescue Leader from DNC Interfaith Gathering at Colorado Convention Center 2Health News:For Rare Blood Disorder, Pumping Iron Is the Cure 2Health News:For Rare Blood Disorder, Pumping Iron Is the Cure 3Health News:Trends in Prescription Medication Sharing Among Reproductive-Aged Women Reported in Journal of Women's Health 2Health News:USP announces new tool to help prevent medication mix-ups due to look alike/sound alike drug names 2
(Date:1/15/2014)... novel wearable injector slightly larger than an Oreo cookie may ... prescription drugs in the large doses required to treat a ... and genetic disorders.  An emerging biologic drugs ... to analysts.   Many of these drugs will require a new ...
(Date:1/14/2014)... 2014 Dynamic Healthcare Services, Inc. ("DHS"), a portfolio company ... Progressive Home Medical Equipment, Inc. ("Progressive") of Clarion, ... the acquisition were not disclosed. Progressive is ... wide range of sleep, mobility, and respiratory products to customers ...
(Date:1/14/2014)... , Jan. 14, 2014   Oligomerix, Inc. , a ... therapeutics for Alzheimer,s disease (AD) and related neurodegenerative disorders, ... Valhalla, NY as of January ... space at New York Medical College. Oligomerix, ...
Breaking Medicine Technology:Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Oligomerix Relocates Corporate Headquarters and Secures Additional Laboratory Space from New York Medical College 2
... Our Buffered Wright-Giemsa Stain is ... contains the fixative, buffer, and ... staining of blood smears. It ... bottle for ease of use ...
Our Wright stain is a dual-use stain for peripheral blood and bone marrow smears. It produces results similar to those of the Giemsa stain with a slightly greater contrast....
Albumin FS for determination of albumin in serum or plasma. For Hitachi 704 / 911. Available with Calibrator: Trucal U and Controls: Trulab N and Trulab P....
ASAT (GOT) FS (IFCC mod). For determination of ASAT (GOT) in serum or plasma. For Hitachi 717. Controls: Trulab N and Trulab P....
Medicine Products: