Navigation Links
Pinpointing cause of colic: UT Houston researchers identify organism
Date:7/24/2009

Researchers at The University of Texas Health Science Center at Houston say one organism discovered during their study may unlock the key to what causes colic, inconsolable crying in an otherwise healthy baby.

"Right now, pediatric gastroenterologists can treat just about anything that comes through the door," said J. Marc Rhoads, M.D., professor of pediatrics at The University of Texas Medical School at Houston, which is part of the UT Health Science Center at Houston. "With colic, there is no evidence-based treatment we can offer. Colic can be a dangerous situation for a baby. The parent's frustration over the crying can lead to maternal frustration, post-partum depression and even thoughts of harming the baby."

Published in today's online edition of the Journal of Pediatrics, the study pointed to an organism called Klebsiella, a normally occurring bacterium that can be found in the mouth, skin and intestines. In the study of 36 babies, half of which had colic, researchers found the bacterium and gut inflammation in the intestines of the babies with colic.

"We believe that the bacterium may be sparking an inflammatory reaction, causing the gut inflammation," said Rhoads, the lead investigator for the study. "Inflammation in the gut of colicky infants closely compared to levels in patients with inflammatory bowel disease. Colic could prove to be a precursor to other gastrointestinal conditions such as irritable bowel syndrome, celiac disease and allergic gastroenteropathies."

Babies in the study were fed breast milk and/or formula. Previous research articles have not shown significant data supporting the theory that breastfeeding protects infants against colic. The babies in the study were recruited from UT Physicians' pediatric clinics and Kelsey-Seybold clinics.

Colic is defined as unexplained and severe crying in an otherwise healthy newborn. It usually occurs in infants three months old or younger and lasts for more than three hours daily for at least three days a week."Colic is a very common condition. It affects about 15 percent of normal, healthy infants. More than half of infanticides fall into the age category of colic. We may be able to prevent deaths if we can find a treatment," Rhoads said.

Right now, pediatricians prescribe special hypoallergenic infant formula to try and treat colic, but none of it has been proven in studies to be effective in treating the condition.

"During our study, we also found that the babies that didn't have colic had more types of bacteria in their intestines. The presence of more bacteria may indicate that specific bacterial species (phylotypes) are beneficial to humans," Rhoads said.

The study was funded by the Gerber Foundation.

A larger study is needed to examine Klebsiella and the use of a probiotic, which is a dietary supplement made up of good bacteria, to control the gut inflammation. Before that can begin, Rhoads said an adult trial will take place to examine the safety of the probiotics in healthy adults. For that study, UT researchers are recruiting 40 adult patients.


'/>"/>

Contact: Melissa McDonald
Melissa.E.McDonald@uth.tmc.edu
713-500-3308
University of Texas Health Science Center at Houston
Source:Eurekalert

Related medicine news :

1. VIDEO from Medialink and Siemens: Pinpointing Prostate Cancer in Larger Patients
2. NIH Plan Charts Course to Better Treatments and Cure for Most Common Known Genetic Cause of Autism: Fragile X
3. Large abdominal wall lipoma causes bowel obstruction
4. Fitness Gurus Warn Women Not To Give Up On Their Diet Just Because Summer Has Arrived
5. Was SIDS the cause of infant deaths even 150 years ago?
6. Drug Crimes in Canada Cause Continuing Problems for Small Communities
7. Catastrophic Epilepsy Caused by Defect in One Gene
8. NIA Says Health Care Will Cause U.S. Dollar Collapse
9. Mini-Strokes May Cause Vision Loss
10. Statins May Cause Muscle Damage in Some Patients
11. CU-Boulder study shows brains immune system may cause chronic seizures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs ... College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. ... treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. ...
(Date:6/25/2016)... ... 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned ... the David Geffen School of Medicine at UCLA. He trained in Internal Medicine at ... fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity ...
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Scientific Sessions in Dallas that it will receive two significant new grants to ... came as PHA marked its 25th anniversary by recognizing patients, medical professionals and ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief ... a minimum wage raise to $12 an hour by 2020 and then adjusting it yearly ... lost value of the minimum wage, assure the wage floor does not erode again, and ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Global MEMS Devices Medical Market Analysis 2016 - Forecast to ... The report contains up to date financial ... reliable analysis. Assessment of major trends with potential impact on ... dive analysis of market segmentation which comprises of sub markets, ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 /PRNewswire/ ... Diabetes Tomorrow,s Leaders Scholarship is any indication, the future ... today online at www.diabetesscholars.org by the Diabetes ... stand in the way of academic and community service ... scholarship program since 2012, and continues to advocate for ...
(Date:6/23/2016)... June 23, 2016 Research and ... Procedure Volumes: Global Analysis (United States, China, Japan, Brazil, ... report to their offering. ... for healthcare business planners, provides surgical procedure volume data ... trends with an in-depth analysis of growth drivers and ...
Breaking Medicine Technology: