Navigation Links
Pigs Yield Clues to Cystic Fibrosis-Related Lung Disease
Date:4/28/2010

Infection appears to precede inflammation, researchers find

WEDNESDAY, April 28 (HealthDay News) -- Researchers say they have answered a long-standing question regarding lung disease caused by cystic fibrosis: Which comes first, infection or inflammation?

"Using our model, we are beginning to answer that question, and it looks like infection does precede inflammation," study author Dr. David Stoltz, an assistant professor of internal medicine at the University of Iowa, said in a news release from the school. "The importance of that finding is that it could dictate what types of therapy we might use. Knowing that infection is first suggests that if we can prevent or fight infection, then that might delay or prevent the lung disease in people with CF."

Most of the deaths and disability in people with CF result from lung disease.

The findings also appear to suggest that lung infections in children with cystic fibrosis should be treated early and aggressively, Stoltz said.

The researchers reached their conclusions by studying pigs with a genetic mutation that causes cystic fibrosis.

"This is a really great example where the pig serves as a model for what happens in the human, and the pig reacts to this disease in nearly the same way," study co-author Randall Prather, distinguished professor of reproductive biotechnology at the University of Missouri, said in the news release. "In contrast, when you use mice, they don't get the lung disease that is common in patients with cystic fibrosis."

The study was published online April 28 in the journal Science Translational Medicine.

More information

For more about cystic fibrosis, see the U.S. National Library of Medicine.



-- Randy Dotinga



SOURCE: University of Iowa, news release, April 28, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. LSUHSC research yields promising stroke treatment
2. Compulsive Dogs Yield Clues to Human OCD, Autism
3. Battlefield camaraderie yields long-term dividends for veterans, study finds
4. Why do physicians order costly CTs? Ultrasound yields better diagnosis, safer, less costly
5. Gene Sequencing Yields Picture of Human Gut
6. HealthSouth To Present at Barclays Capital 2010 High Yield Bond and Syndicated Loan Conference
7. Abbreviated Trials Yield Misleading Results: Study
8. H1N1 Virus Yields Up More Secrets
9. Safety and diagnosis yield of colonoscopy in Hong Kong Chinese children
10. Glued graft for Pterygium Yield Better Cosmetic Results
11. Review Spotlights Clues to Serious Childhood Infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the ... AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in ... topics including advance care planning, healthcare costs and patient and family engagement. , ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room ... Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
(Date:6/24/2016)... SOUTH SAN FRANCISCO, Calif. , June 24, ... GBT ), a biopharmaceutical company developing novel ... with significant unmet needs, today announced the closing ... 6,400,000 shares of common stock, at the public ... the shares in the offering were offered by ...
(Date:6/24/2016)... , June 24, 2016 The Academy of ... recommendations that would allow biopharmaceutical companies to ... entities that make formulary and coverage decisions, a move ... of new medicines. The recommendations address restrictions ... appear on the drug label, a prohibition that hinders ...
Breaking Medicine Technology: