Navigation Links
Pieris and Pepscan to Identify GPCR-Specific Anticalins(R) Using CLIPS(TM) Protein Mimicry Technology
Date:10/30/2007

FREISING-WEIHENSTEPHAN, Germany, October 30 /PRNewswire/ -- Pieris AG (Munich, Germany) and Pepscan Therapeutics (Lelystad, Netherlands) today announced the commencement of a research collaboration aimed at identifying Anticalins(R) specific for G-Protein Coupled Receptors (GPCRs) and their development as therapeutic candidates.

Pieris has pioneered Anticalins(R) as next generation targeted therapeutics with clear advantages over monoclonal antibodies, while Pepscan has developed CLIPS(TM) technology to yield immunogens targeting functional epitopes on proteins. Through this newly announced collaboration, the companies aim to combine and apply their respective technologies to the discovery and development of novel Anticalins(R) able to modulate GPCR function in disease.

GPCRs form one of the most important classes of drug targets, yet for many of these receptors, no pharmacologically active small molecule drugs have been identified. Biotherapeutics provide an intriguing alternative if they can be selectively targeted to functional epitopes, yet monoclonal antibodies modulating GPCR action have to date proven technically challenging. Pepscan's CLIPS(TM) technology has the distinct advantage of selectively identifying functional mimics of the extracellular portions of GPCRs which are fundamental in biology. Such mimics will be used by Pieris to select Anticalins(R) with disease modifying potential.

"Pieris has successfully isolated and characterised high potency Anticalins(R) against structurally diverse functional epitopes on a wide range of medically relevant proteins", said Dr Andreas Hohlbaum, Director of Science and Preclinical Development at Pieris. "Incorporating Pepscan's CLIPS(TM) technology into our selection and screening process now allows us to discover Anticalins(R) with high affinity and selectivity for specific GPCRs".

Dr Rob Meloen, Chief Scientific Officer of Pepscan Therapeutics commented: "Functional binding proteins
'/>"/>

SOURCE Pieris AG
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine news :

1. Laboratory Testing Can Identify Risk of Pre-Term Labor and Delivery
2. Now you can identify Sperm and Egg donors
3. Identifying Predictors Of Anthrax
4. Identifying The Risks Of Developing Schizophrenia
5. Researchers identify the early makers of Neonatal Sepsis
6. Researchers Identify Gene Connected To Bipolar Disorder
7. Blood test may identify ovarian cancer
8. Identifying bacteria made amiable
9. Latest device for identifying Melanomas
10. Identifying brain lesions with impaired consciousness
11. Identifying Virus Found To Be Essential for HIV Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... In an effort to expand services and improve efficiency ... will soon offer orthodontics at his Oral & Maxillofacial Surgery ... , To build upon the high degree of care and ... known for, Dr. Jamali is welcoming an orthodontist that is ... as UCLA, Stanford and UCSF. He added that the new ...
(Date:10/31/2014)... 2014 Phoenix dentist , Dr. Christy, ... November. Whether patients simply need routine care or have a ... than now to get that necessary care. The right dental ... routine and even essential treatments due to financial concerns. Throughout ... on any treatments offered by the team at Christy Dental ...
(Date:10/31/2014)... Uniwigs.com newly arrived flip in hair extensions are ... itself around people’s heads with a transparent miracle wire undetectable ... comes with adjustable loops, which are improved over the basic ... now adjust the wire to best fit the size of ... generation of flip ins, they simply need to adjust the ...
(Date:10/31/2014)... 31, 2014 Med-Care Diabetic & Medical ... highest principles of patient care and service, announced a ... and wellness website, to provide an online Diabetes ... , The Diabetes Health Center will provide topical information ... living with diabetes. Content will feature advice from leading ...
(Date:10/31/2014)... FRIDAY, Oct. 31, 2014 (HealthDay News) -- A few simple ... cope with, a sleep expert says. "Adjusting to the ... bit easier than handling the time change in the spring. ... sleep for the fall time change," Dr. Praveen Rudraraju, director ... in Mount Kisco, N.Y., said in a hospital news release. ...
Breaking Medicine News(10 mins):Health News:Oral & Maxillofacial Surgery of New York Adds Orthodontic Patient Services 2Health News:Oral & Maxillofacial Surgery of New York Adds Orthodontic Patient Services 3Health News:Phoenix Dentist, Dr. Christy, is Now Offering Ten Percent Off On All Dental Treatments for the Month of November 2Health News:UniWigs Unveiles New Generation of Flip In Hair Extensions 2Health News:Med-Care Diabetic & Medical Supplies, Inc. Partners with Lifescript to Provide Online Diabetes Health Center 2Health News:Med-Care Diabetic & Medical Supplies, Inc. Partners with Lifescript to Provide Online Diabetes Health Center 3Health News:Make the Most of This Weekend's Time Change 2
... co-authored by Rice political scientists Mark Jones and William ... patterns and/or aberrations in the use of Tasers related ... titled "A Statistical Analysis of the Use of Conducted ... section of a larger report, "Conducted Energy Device Program ...
... Pa., Sept. 9 Governor Edward G.,Rendell today ... who has,served as Secretary of the Pennsylvania Department ... been a passionate voice for protecting and improving,the ... has,distinguished himself as an effective leader, addressing a ...
... the Retirement ... NORTH CONWAY, N.H., Sept. 9 It,s no secret ... population grows, so,does the need to house them. According to ... homes, 39,500 assisted living,facilities and 1,900 continuing care retirement communities ...
... Patients and Payors To,Become Engaged and Accountable, WASHINGTON, ... Press Club, Medco Health Solutions, Inc. (NYSE: MHS ... pragmatic blueprint for fixing,America,s inefficient health care system that, ... causes of the problem. Unifying the strengths,of both the ...
... a state of craving, they may underestimate intensity of future ... -- If you,re not craving a hit of nicotine the ... got a little tougher, say researchers at the University of ... previously that the idea of smoking a cigarette becomes increasingly ...
... 9 Transcend Medical, Inc., an,ophthalmic device company dedicated ... that Brian J. Walsh was named as President,and Chief ... Reza,Zadno as Chairman of the Board of Directors., ... said Eugene de Juan,Jr., M.D., the founder of ForSight ...
Cached Medicine News:Health News:Rice political scientists co-author report on ethnic/racial aspects of Taser use by Houston police 2Health News:Governor Rendell Announces Resignation of Health Secretary Dr. Calvin Johnson 2Health News:SeniorHousingJobs.com Celebrates Its 5th Anniversary 2Health News:Medco CEO Unveils Pragmatic Blueprint for Health Care Reform; Reducing Costs by Upwards of $1 Trillion 2Health News:Medco CEO Unveils Pragmatic Blueprint for Health Care Reform; Reducing Costs by Upwards of $1 Trillion 3Health News:Medco CEO Unveils Pragmatic Blueprint for Health Care Reform; Reducing Costs by Upwards of $1 Trillion 4Health News:Study Probes Why Smokers Find It Hard to Quit 2Health News:Transcend Medical Announces New President and CEO and Appointment of Chairman of the Board 2Health News:Transcend Medical Announces New President and CEO and Appointment of Chairman of the Board 3
(Date:10/31/2014)... 31, 2014 Oramed Pharmaceuticals ... company focused on the development of oral drug ... a conference call to discuss the clinical results ... the company,s proprietary oral insulin capsules, to treat ... at 10:00 a.m. Eastern time. Shareholders ...
(Date:10/31/2014)... 31, 2014 Investor-Edge has initiated ... NSPH ), Isis Pharmaceuticals Inc. (NASDAQ: ... ), ACADIA Pharmaceuticals Inc. (NASDAQ: ACAD ), ... these five companies can be accessed at: http://investor-edge.com/register ... NASDAQ Composite ended at 4,566.14, up 0.37%, the Dow ...
(Date:10/31/2014)... 3, 2014 British Journal ... BPH to discuss "male orgasmic dysfunction" with their doctor ... treat prostate symptoms while preserving sexual function   ... publication of a paper in the British Journal of ... prostate to discuss with their doctors the likely impact ...
Breaking Medicine Technology:Oramed to Report Key Top Line Results from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 2Oramed to Report Key Top Line Results from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 3Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 2Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 3Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 4Momentum Indicators for Biotech Stocks -- Nanosphere, Isis Pharma, Halozyme Therapeutics, ACADIA Pharma, and Synta Pharma 5Sexual Dysfunction No Longer Inevitable When Treating Enlarged Prostate 2
... 15, 2011 BME (BioMedical Enterprises, Inc.), a developer ... announce the United States launch of Speed™. It is ... made available to orthopaedic and podiatric surgeons. ... implants, applied its extensive knowledge in memory metal implant ...
... RALEIGH, N.C., Nov. 15, 2011 PRA, a leading ... Development Services (EDS) experts will present at the European ... 16-18 November 2011. PRA will also host an exhibit ... 14:45PM CET, Dr. Nico van de Merbel, Scientific Director ...
Cached Medicine Technology:PRA Early Phase Experts to Speak at Bioanalysis Conference 2
Used for stone manipulation and removal in the urinary tract. The hollow shaft allows protected delivery of a laser fiber to an entrapped stone for fragmentation of the stone. Supplied sterile in pee...
Only SurLok combines precise control, enhanced basket and grasper strength, and the added security of a unique wire-locking mechanism. You can feel the difference. The SurLok flat-wire and grasper ha...
... and removal in the urinary tract. The nitinol ... shape following extreme torsion. The unique tipless design ... basket to open at the base of the ... reduces the likelihood of mucosal damage and perforation. ...
... Filiform Spiral Tip 12 Inch , ... 1/56" female thread. Available in 3,4,5 6Fr. ... a strong but flexible polymer material and ... with other brands. They are manufactured to ...
Medicine Products: