Navigation Links
Pieris Strengthens its Management, as it Prepares for the Clinical Development of PRS-050, an Anticalin(R)-Based Novel Cancer Therapy
Date:11/8/2007

FREISING-WEIHENSTEPHAN, Germany, November 8 /PRNewswire/ -- Pieris AG, a biopharmaceutical company developing Anticalins(R), a novel class of targeted human protein therapeutics, today announced the appointment of Dr Angelika Stern as Chief Operating Officer to the Company. Pieris has also announced the promotion with immediate effect of Dr Andreas Hohlbaum from the position of Director of Science and Preclinical Development to Chief Technology Officer.

The appointment of Dr Angelika Stern at Pieris coincides with continued progress of the Company's Anticalin(R) development programs towards the clinic. PRS-050, Pieris' most advanced program addressing the modulation of VEGF for the treatment of cancer, is currently being prepared for a Phase I study in patients with advanced malignancies. Projected to start in 2009, the study aims to assess the safety, pharmacokinetics and immunogenicity of a half-life extended version of the PRS-050 Anticalin(R), as well as examining its biological activity.

Dr Stern has considerable experience in the clinical development of biologics in the pharmaceutical industry, specifically Phase I - III development and registration of GM-CSF (Leucomax(R)) at Novartis in cooperation with Schering-Plough and subsequently as Medical Director for Neupogen(R) at F. Hoffmann-La Roche. Dr Stern co-founded Hesperion Ltd, a Swiss based international CRO, where she advised emerging biotech companies on development strategy issues.

Commenting on her appointment Dr Stern said: "I am very impressed with Pieris' recent progress and the opportunities in biotherapeutic product development presented by the Anticalin(R) technology. PRS-050 exemplifies the enormous potential Pieris has in building a broad pipeline of therapeutics across multiple disease areas."

Evert Kueppers, Chief Executive Officer of Pieris, commented: "I am delighted to welcome Angelika Stern to our senior management team at this exciting stage in the Company's evolution. Attracting such an experienced executive is another milestone for Pieris, as we progress our proprietary Anticalin(R) programs towards the clinic. Furthermore, I am pleased to recognize the tremendous achievements made at Pieris by Andreas Hohlbaum in the past 18 months."

Notes to Editors

About Pieris AG

Pieris is a biopharmaceutical company engaged in the discovery and development of Anticalins(R), a novel class of targeted human proteins designed to diagnose and treat serious human disorders. Exploiting extensive know-how in protein engineering as part of a broad intellectual property portfolio, the Company applies a balanced risk business model to the development of Anticalin product candidates.

About Anticalin(R) Technology

Anticalins(R) are engineered by Pieris from the scaffold of human lipocalins, a family of natural ligand binding proteins. Anticalins are selected to have prescribed binding properties with selectivity and affinity fundamentally similar to that of monoclonal antibodies. Being human in origin, Anticalins are predicted to have minimal immunogenicity in man. Where Anticalins benefit compared to conventional antibodies is in their small size (20 kDa), their robust physicochemical properties and their simple composition that together allow highly soluble, predictably stable products to be manufactured from bacteria. Anticalins are amenable to further engineering to balance their favorable tissue penetration with adjustable serum clearance. Moreover, Anticalins have been developed as Duocalins(R), whose dual targeting format allows multiple targets to be bound and modulated through a single molecule.

Pieris and its collaborators are not only able to develop superior biotherapeutics, but can do so outside the complex patent landscape that encumbers the development of conventional antibody products.

About VEGF and PRS-050

Angiogenesis - the development of new blood vessels from pre-existing vasculature - plays an important role in several diseases. Although various pro- and anti-angiogenic factors have been identified, Vascular Endothelial Growth Factor (VEGF) has been implicated as the key pro-angiogenic factor in cancer.

The PRS-050 program has been designed to develop Anticalins(R) that specifically bind and block the signalling activity of VEGF in cancer. PRS-050, an Anticalin with extended serum half-life, exhibits comparable binding and functional in vitro activity to currently approved VEGF antagonists. Potent inhibition of VEGF-induced enhanced vascular permeability and angiogenesis, as well as anti-tumour activity, have already been demonstrated by PRS-050 in various well-validated preclinical studies.

Pieris' PRS-050 program exploits a number of favourable characteristics of Anticalins, including compact protein structure, high intrinsic stability, broad formulation flexibility and small molecular size, to develop more effective products for the penetration of neovascularized tumour tissue.

Further information is available at http://www.pieris-ag.com

Anticalin(R) and Duocalin(R) are registered trademarks of Pieris AG.

For further information, please contact:

Pieris AG

Phone +49(0)8161-1411-400

Evert Kueppers, Chief Executive Officer


'/>"/>
SOURCE Pieris AG
Copyright©2007 PR Newswire.
All rights reserved

Related medicine news :

1. Pieris and Pepscan to Identify GPCR-Specific Anticalins(R) Using CLIPS(TM) Protein Mimicry Technology
2. Kenyan malaria success strengthens call for free insecticide-treated nets for all
3. International study strengthens case for daily calcium pill
4. Wachovia Strengthens Its Healthcare Industry Receivables and Cash Management Capabilities
5. Essilor Strengthens its Polarized Lens Distribution Network With the Acquisition of KBco
6. Publicis Groupe Strengthens its Leadership in Digital and Integrated Healthcare Communications in Italy
7. NIAID strengthens and expands Vaccine and Treatment Evaluation Units
8. New Records & Information Management: Are You Spending Right on Records Management, Data Security and Compliance?
9. Radiologists encouraged to look beyond cancer for clinically unseen diseases
10. Clinical depression linked to abnormal emotional brain circuits
11. Preclinical study suggests organ-transplant drug may aid in lupus fight
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... AxoGen, Inc. ... will report results for the fourth quarter and full year ended December 31, 2015 ... a conference call and webcast for the investment community following the release at 4:30 ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... measure change in their patients. Research shows that the Goal Attainment Scale (GAS) ... therapists overcome this challenge and learn more about the Goal Attainment Scale, Education ...
(Date:2/10/2016)... Palm Beach, Florida (PRWEB) , ... February 10, ... ... & Country Club) announced that it has been awarded the prestigious Distinguished Emerald ... the World award program conducted by BoardRoom magazine, one of the most respected ...
(Date:2/10/2016)... ... February 10, 2016 , ... The ... 26th: Amateur & Professional Divisions - Time: 7:00pm – 10:00pm | Ticket ... Ticket Prices $30, Social Media: http://www.USPoleSportsFed.org , Facebook: http://www.facebook.com/uspolesportsfederation , ...
(Date:2/10/2016)... ... February 10, 2016 , ... The recreational use of marijuana has been ... still face a lot of restrictions as to where they can smoke pot. ... use” and that cannabis “may not be consumed openly or publicly.” , Given the ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... February 10, 2016 Demonstrates ... 1 receptor selectivity   1 ... which has entered clinical development as a new ... and schizophrenia.   --> 1 ... has entered clinical development as a new treatment ...
(Date:2/9/2016)... Feb. 9, 2016  Landauer, Inc. (NYSE: LDR ... measurement and monitoring, outsourced medical physics services and high ... its fiscal 2016 first quarter ended December 31, 2015. ... Fiscal 2016 First Quarter Highlights , Revenue of ... quarter of 2015 , Domestic Radiation Measurement services revenues ...
(Date:2/9/2016)... BioSciences, Inc. (NASDAQ: SGMO ), the leader ... quarter and full year 2015 financial results and ... editing," said Edward Lanphier, Sangamo,s president and chief ... leads the therapeutic genome editing field and we ... our ground-breaking genome editing programs through IND enabling ...
Breaking Medicine Technology: